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The map label for this gene is mvaB [H]

Identifier: 71905728

GI number: 71905728

Start: 102677

End: 103582

Strand: Reverse

Name: mvaB [H]

Synonym: Daro_0086

Alternate gene names: 71905728

Gene position: 103582-102677 (Counterclockwise)

Preceding gene: 71905729

Following gene: 71905727

Centisome position: 2.3

GC content: 59.05

Gene sequence:

>906_bases
ATGTCCCTCCCCGCCAAAGTCAAAATCGTCGAAGTCGGCCCGCGTGACGGACTGCAGAACGAAAAGCTGGTCGTCCCGAC
CGACATCAAGATCGAACTGATCAACCGACTGGCCGATGTCGGCCTGAGCGTCATCGAGGCCACCTCCTTCGTATCGCCGA
AGTGGGTGCCGCAGATGGGCGACAACGCTGCCGTGATGCAGGGCATCAAGCGGAACCCGTCGACCATTTACACAGCCTTG
ACGCCAAATCTGCAGGGATTTGATGGTGCCGTACAGGCCGGCGCCAACGAAGTCGCCATTTTTGGTGCGGCATCGGAGAG
TTTTTCCCGAAAAAACATCAATTGCTCGATCGCCGAGAGCCTGAAACGCTTCGAACCCGTCGTTTCAGCCGCTTCGGCAC
TGGAAATCCCGGTCCGCGGCTATGTATCCTGCGTTGTCGGCTGCCCCTACGAGGGTGCGATCGATCCGCACAAAGCCGCC
GATGTGGCGAAAATCCTGTTCGACATGGGCTGCTACGAAGTCTCGCTCGGCGACACCATCGGTGTTGGCAATCCGGCCAC
CATCCAGCGCATGATCGAGGCCTGTGCAAAACATATCCCGATCAGCAAGCTGGCCGGGCACTATCACGATACCTACGGCA
TGGCCATCGCCAACATCTACGCTTCGCTGGAGATGGGCATGGCAGTTTTCGACAGTTCCATCGCCGGCCTCGGCGGCTGC
CCCTACGCTAAAGGGGCCTCCGGCAATGTGGCGACCGAAGACGTCGTTTATTTATTACACGGCCTGGGCATTGAAACCGG
CATCGATCTGGCTAAACTGGCAGGTATCGGCGACTGGATTTCCAGCGCCATCAATCGCCCGAATGGAGCCAAGGCCGGCC
GGGCCCTTTGTACCGGGAACGAGTGA

Upstream 100 bases:

>100_bases
TGGGTGATGCGCTAGCGAAGCCTGATCCCGCTGCTTTAAAACGAATAGCGCCTGCTTTTGTTTAACCAAACCTCTCAAAA
TCCACTGCCGAGCATTCGCC

Downstream 100 bases:

>100_bases
GCCTTTTTTCTGCTGTAAGCGATTTTCTCAAGCCTGACCCGCCACTGGATTCATCCGTCCAGAAAGCACTGGACCGGGTC
GCCGAACTCGTCGACCCGCT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSLPAKVKIVEVGPRDGLQNEKLVVPTDIKIELINRLADVGLSVIEATSFVSPKWVPQMGDNAAVMQGIKRNPSTIYTAL
TPNLQGFDGAVQAGANEVAIFGAASESFSRKNINCSIAESLKRFEPVVSAASALEIPVRGYVSCVVGCPYEGAIDPHKAA
DVAKILFDMGCYEVSLGDTIGVGNPATIQRMIEACAKHIPISKLAGHYHDTYGMAIANIYASLEMGMAVFDSSIAGLGGC
PYAKGASGNVATEDVVYLLHGLGIETGIDLAKLAGIGDWISSAINRPNGAKAGRALCTGNE

Sequences:

>Translated_301_residues
MSLPAKVKIVEVGPRDGLQNEKLVVPTDIKIELINRLADVGLSVIEATSFVSPKWVPQMGDNAAVMQGIKRNPSTIYTAL
TPNLQGFDGAVQAGANEVAIFGAASESFSRKNINCSIAESLKRFEPVVSAASALEIPVRGYVSCVVGCPYEGAIDPHKAA
DVAKILFDMGCYEVSLGDTIGVGNPATIQRMIEACAKHIPISKLAGHYHDTYGMAIANIYASLEMGMAVFDSSIAGLGGC
PYAKGASGNVATEDVVYLLHGLGIETGIDLAKLAGIGDWISSAINRPNGAKAGRALCTGNE
>Mature_300_residues
SLPAKVKIVEVGPRDGLQNEKLVVPTDIKIELINRLADVGLSVIEATSFVSPKWVPQMGDNAAVMQGIKRNPSTIYTALT
PNLQGFDGAVQAGANEVAIFGAASESFSRKNINCSIAESLKRFEPVVSAASALEIPVRGYVSCVVGCPYEGAIDPHKAAD
VAKILFDMGCYEVSLGDTIGVGNPATIQRMIEACAKHIPISKLAGHYHDTYGMAIANIYASLEMGMAVFDSSIAGLGGCP
YAKGASGNVATEDVVYLLHGLGIETGIDLAKLAGIGDWISSAINRPNGAKAGRALCTGNE

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=62.7986348122867, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=62.7986348122867, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI62198232, Length=296, Percent_Identity=60.472972972973, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI260654708, Length=138, Percent_Identity=55.7971014492754, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17510563, Length=292, Percent_Identity=50.6849315068493, Blast_Score=310, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24582381, Length=290, Percent_Identity=59.3103448275862, Blast_Score=370, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31439; Mature: 31308

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPAKVKIVEVGPRDGLQNEKLVVPTDIKIELINRLADVGLSVIEATSFVSPKWVPQMG
CCCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DNAAVMQGIKRNPSTIYTALTPNLQGFDGAVQAGANEVAIFGAASESFSRKNINCSIAES
CCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
LKRFEPVVSAASALEIPVRGYVSCVVGCPYEGAIDPHKAADVAKILFDMGCYEVSLGDTI
HHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCC
GVGNPATIQRMIEACAKHIPISKLAGHYHDTYGMAIANIYASLEMGMAVFDSSIAGLGGC
CCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYAKGASGNVATEDVVYLLHGLGIETGIDLAKLAGIGDWISSAINRPNGAKAGRALCTGN
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCC
E
C
>Mature Secondary Structure 
SLPAKVKIVEVGPRDGLQNEKLVVPTDIKIELINRLADVGLSVIEATSFVSPKWVPQMG
CCCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DNAAVMQGIKRNPSTIYTALTPNLQGFDGAVQAGANEVAIFGAASESFSRKNINCSIAES
CCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHH
LKRFEPVVSAASALEIPVRGYVSCVVGCPYEGAIDPHKAADVAKILFDMGCYEVSLGDTI
HHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCC
GVGNPATIQRMIEACAKHIPISKLAGHYHDTYGMAIANIYASLEMGMAVFDSSIAGLGGC
CCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYAKGASGNVATEDVVYLLHGLGIETGIDLAKLAGIGDWISSAINRPNGAKAGRALCTGN
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]