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The map label for this gene is cobB [H]

Identifier: 71905648

GI number: 71905648

Start: 6432

End: 7247

Strand: Reverse

Name: cobB [H]

Synonym: Daro_0006

Alternate gene names: 71905648

Gene position: 7247-6432 (Counterclockwise)

Preceding gene: 71905649

Following gene: NA

Centisome position: 0.16

GC content: 63.6

Gene sequence:

>816_bases
ATGACCGATCCCGCTCTTGAACAAGCCGTGGCATGGCTGCGCGCCGCAGATGCTTTGTTGGTTACCGCCGGAGCCGGTAT
GGGCATCGACTCCGGGCTGCCTGACTTTCGTGGGCCGGGCGGCTTCTGGTCGGTTTATCCTGCGCTGGGGCGGGCCAGAA
TCGCCTTTGAGTCCATCGCCAACCCGGCGGCCTTCGAATGCGACCCGCGGCTGGCCTGGGGCTTCTACGGCCATCGGCTC
GATCTCTACCGCCACACCACACCTCATGCCGGGTTTCGGATGCTGCTCGACATGGCACAAGGGATGCAACATGGCATCCG
GGCCTTCACCAGCAACGTCGATGGCCAGTTCCAGAAAGCCAGTTTTGCCGCCGACCAGGTCTGCGAAATCCACGGCTCCA
TCCATCATCTCCAATGCACCACCGCTTGCCGTGAGCGCATCTGGCCAGCCAATGACTTCCGGCCGGAAGTCGATGCCGAG
AACTGTCGCCTGCTCGGCGATCTGCCCATTTGCCCACACTGCGGCGCCCTCGCCCGGCCCAATATCCTGATGTTCAACGA
CTGGGGCTGGCTGGAGCGGCGCACAACATCGCAATACCAAGGCCTGCGACAGTGGCTGACCACGGTTGAGCGGCTGGTCT
GCATAGAAATCGGCGCCGGCACCAACATTCCGACCGTCCGGCATTTCTCCGAAGACTGTGGCGGCAAGCTGATCCGCATT
AACCCTGGCGAACCCGATGTACCCAATCCGGCGGCCGGCATCGGCCTGGCGCTGGGCGGCCTCGCCGGCCTCACCCTGCT
GAGTCAGGCACTATAG

Upstream 100 bases:

>100_bases
TTTCGAGTAAGCCGGCTCGTCCTGAAACTCACCCACGGGGAAAACTGATCTCCCAATTGGACACGACAGCCCTCCCGGCG
ACGGAAATAGCCATTTGTCG

Downstream 100 bases:

>100_bases
TGCCTATTCAGGCACTTTGGAGTCGATCGTCAGCGTTACCGGACCATCGTTAATCAGGCTGACCTGCATATCGGCGCCAA
ACACCCCGGTCGGTACTGCC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTDPALEQAVAWLRAADALLVTAGAGMGIDSGLPDFRGPGGFWSVYPALGRARIAFESIANPAAFECDPRLAWGFYGHRL
DLYRHTTPHAGFRMLLDMAQGMQHGIRAFTSNVDGQFQKASFAADQVCEIHGSIHHLQCTTACRERIWPANDFRPEVDAE
NCRLLGDLPICPHCGALARPNILMFNDWGWLERRTTSQYQGLRQWLTTVERLVCIEIGAGTNIPTVRHFSEDCGGKLIRI
NPGEPDVPNPAAGIGLALGGLAGLTLLSQAL

Sequences:

>Translated_271_residues
MTDPALEQAVAWLRAADALLVTAGAGMGIDSGLPDFRGPGGFWSVYPALGRARIAFESIANPAAFECDPRLAWGFYGHRL
DLYRHTTPHAGFRMLLDMAQGMQHGIRAFTSNVDGQFQKASFAADQVCEIHGSIHHLQCTTACRERIWPANDFRPEVDAE
NCRLLGDLPICPHCGALARPNILMFNDWGWLERRTTSQYQGLRQWLTTVERLVCIEIGAGTNIPTVRHFSEDCGGKLIRI
NPGEPDVPNPAAGIGLALGGLAGLTLLSQAL
>Mature_270_residues
TDPALEQAVAWLRAADALLVTAGAGMGIDSGLPDFRGPGGFWSVYPALGRARIAFESIANPAAFECDPRLAWGFYGHRLD
LYRHTTPHAGFRMLLDMAQGMQHGIRAFTSNVDGQFQKASFAADQVCEIHGSIHHLQCTTACRERIWPANDFRPEVDAEN
CRLLGDLPICPHCGALARPNILMFNDWGWLERRTTSQYQGLRQWLTTVERLVCIEIGAGTNIPTVRHFSEDCGGKLIRIN
PGEPDVPNPAAGIGLALGGLAGLTLLSQAL

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=190, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI6912664, Length=190, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI300795542, Length=189, Percent_Identity=29.1005291005291, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325242, Length=205, Percent_Identity=28.2926829268293, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 29532; Mature: 29401

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPALEQAVAWLRAADALLVTAGAGMGIDSGLPDFRGPGGFWSVYPALGRARIAFESIA
CCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NPAAFECDPRLAWGFYGHRLDLYRHTTPHAGFRMLLDMAQGMQHGIRAFTSNVDGQFQKA
CCCCCCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SFAADQVCEIHGSIHHLQCTTACRERIWPANDFRPEVDAENCRLLGDLPICPHCGALARP
HHHHHHHHHHHCCHHEEEHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NILMFNDWGWLERRTTSQYQGLRQWLTTVERLVCIEIGAGTNIPTVRHFSEDCGGKLIRI
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCEEEEE
NPGEPDVPNPAAGIGLALGGLAGLTLLSQAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDPALEQAVAWLRAADALLVTAGAGMGIDSGLPDFRGPGGFWSVYPALGRARIAFESIA
CCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
NPAAFECDPRLAWGFYGHRLDLYRHTTPHAGFRMLLDMAQGMQHGIRAFTSNVDGQFQKA
CCCCCCCCCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
SFAADQVCEIHGSIHHLQCTTACRERIWPANDFRPEVDAENCRLLGDLPICPHCGALARP
HHHHHHHHHHHCCHHEEEHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCC
NILMFNDWGWLERRTTSQYQGLRQWLTTVERLVCIEIGAGTNIPTVRHFSEDCGGKLIRI
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCCEEEEE
NPGEPDVPNPAAGIGLALGGLAGLTLLSQAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA