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The map label for this gene is purK [H]

Identifier: 71909845

GI number: 71909845

Start: 49106

End: 50182

Strand: Direct

Name: purK [H]

Synonym: M5005_Spy_0031

Alternate gene names: 71909845

Gene position: 49106-50182 (Clockwise)

Preceding gene: 71909844

Following gene: 71909846

Centisome position: 2.67

GC content: 49.95

Gene sequence:

>1077_bases
GTGGTGAACTCATTTAAGACCATTGGGATTATCGGTGGTGGTCAGCTGGGGCAGATGATGGCCATTGCGGCTATCTATAT
GGGTCACAAGGTCATCACGCTGGATCCTGCTAGCGACAGCCCTGCCTCCCGCGTTAGCGAGGTAATTGTGGCGCCTTACG
ATGATGTTGAGGCTTTGGGACAATTGGCTGCGCGTTGCGATGTGTTGACTTATGAGTTTGAGAATGTTGATGCGGACGGT
TTGGATGCCGTTGTGTCAGCTTGTCAGCTACCGCAGGGGACCGATCTGCTCCGCATTTCCCAAAACCGTATCGTTGAAAA
AGACTTTCTGGCAAATAAGGCTGGTGTGACAGTCGCTCCCTATAAGGTGGTGACGTCTAGCCTTGACCTAGGGGGGCTTG
ATTTGACCAAGACCTATGTCCTCAAGACAGAGACAGGTGGTTATGACGGTCATGGGCAAAAGATTATCCGCTCAGCAGAA
GATTTGCCAGAGGCGCAGCAATTAGCTAACTCAGCTCAGTGTGTCTTGGAAGAGTTTGTCAACTTTGACCTTGAAATCTC
AGTCATCGTGTCTGGAAATGGCAAGGATGTGACGGTCTTTCCCGTTCAGGAAAATATCCACCGCAACAATATCCTGTCAA
AAACCATCGTACCAGCTCGCATCTCAGATCAACTGGCTGATAAGGCTAAGAAAACGGCGGTGCAGATTGCCAAGAAACTC
CAGCTGTCAGGAACTCTCTGTGTGGAAATGTTTACGACCGCAGATGATATCATTGTCAATGAAATTGCCCCACGCCCCCA
CAACTCAGGGCGCTATTCTATCGAAGCCTGCGACTTTTCACAGTTTGACACCCACATCTTGGGTGTGTTGGGCGCACCAC
TTCCTCAGATTCAGCTCCACGCCCCAGCCGTCATGCTCAATGTCCTAGGACAACATGTCCAGCAGGCAACTGACTATGTT
GCCAAAAACCCTAGCGCCCACCTCCACATGTATGGTAAACTAGAAGCGAAACATAACCGCAAAATGGGACATGTGACGGT
GTTTGCAAAAGATGCGGATGAGGTGAAGGAGTTTTAA

Upstream 100 bases:

>100_bases
GCCCTGACAGCCCTCCGTATCCTCTCTATCGAGGACCAAAATCTGGCTGATGCGCTAGCTCATTTCCATGAGGAACAAGG
AAAAATCGCAGAGGAGTCAA

Downstream 100 bases:

>100_bases
AGAGTTAATTAGGAGATGTTTATTTTATGGCAAATATTCAAATAAATAGAATAAAAAGTAAATTGACAGAACTGTTTAGT
AGTATTATCTATATGGGTAA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVLTYEFENVDADG
LDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAE
DLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKL
QLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVLGQHVQQATDYV
AKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF

Sequences:

>Translated_358_residues
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVLTYEFENVDADG
LDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAE
DLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKL
QLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVLGQHVQQATDYV
AKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF
>Mature_358_residues
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVLTYEFENVDADG
LDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAE
DLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKL
QLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVLGQHVQQATDYV
AKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=356, Percent_Identity=27.8089887640449, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788155, Length=362, Percent_Identity=24.0331491712707, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=376, Percent_Identity=34.0425531914894, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38723; Mature: 38723

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALG
CCCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHEEECCCCCHHHHH
QLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAP
HHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCCCCEECC
YKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAEDLPEAQQLANSAQCVLEEFV
HHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
NFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKL
CCCEEEEEEEECCCCEEEEEECHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLH
HCCCEEEEEEHHCCCHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEC
APAVMLNVLGQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHCC
>Mature Secondary Structure
MVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALG
CCCCEEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHEEECCCCCHHHHH
QLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAP
HHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHCCCCCCEECC
YKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAEDLPEAQQLANSAQCVLEEFV
HHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
NFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKAKKTAVQIAKKL
CCCEEEEEEEECCCCEEEEEECHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLH
HCCCEEEEEEHHCCCHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEC
APAVMLNVLGQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF
CHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEECCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA