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The map label for this gene is purE [H]

Identifier: 71909844

GI number: 71909844

Start: 48511

End: 49122

Strand: Direct

Name: purE [H]

Synonym: M5005_Spy_0030

Alternate gene names: 71909844

Gene position: 48511-49122 (Clockwise)

Preceding gene: 71909843

Following gene: 71909845

Centisome position: 2.64

GC content: 48.53

Gene sequence:

>612_bases
ATGCTAAAGCACCTAGTCGCCCTGACGTGGGTTCGTCTTCGAAATCAAAGATTTCGGACTTACCTCATATTTTTCTACGG
AAAGTTTCGACAAGTCGAAACGCCCCTTTGTATCTTAATTATGAAAACTCCAATTATTTCTATTATCATGGGCTCCAAAT
CTGACTGGGCAACCATGCAAAAAACGGCTGAAGTTCTAGACAACTTTGGCATTGCTTACGAGAAGAAAGTCGTCTCTGCC
CACCGTACGCCAGACCTCATGTTCAAGCATGCTGAGGAAGCACGTGGTCGTGGCATCAAAATCATCATCGCAGGAGCAGG
TGGGGCAGCTCACTTGCCTGGTATGGTGGCAGCTAAAACAACGCTGCCTGTTATCGGTGTGCCTGTCAAATCACGTGCCC
TTTCAGGTTTGGATTTGCTATATTCCATTGTGCAGATGCCTGGCGGTGTGCCTGTGGCAACCATGGCTATCGGAGAAGCG
GGAGCGACTAACGCTGCCCTGACAGCCCTCCGTATCCTCTCTATCGAGGACCAAAATCTGGCTGATGCGCTAGCTCATTT
CCATGAGGAACAAGGAAAAATCGCAGAGGAGTCAAGTGGTGAACTCATTTAA

Upstream 100 bases:

>100_bases
AAAGAAGAAAGGAACTGAACACGGGACTAATTTCCCAGGAAAAAAATAAAACTACCTGGACGCAAGCGTCATCGTTAGTT
TTCTGCGTCGTAGGCGTCTG

Downstream 100 bases:

>100_bases
GACCATTGGGATTATCGGTGGTGGTCAGCTGGGGCAGATGATGGCCATTGCGGCTATCTATATGGGTCACAAGGTCATCA
CGCTGGATCCTGCTAGCGAC

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIMGSKSDWATMQKTAEVLDNFGIAYEKKVVSA
HRTPDLMFKHAEEARGRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDLLYSIVQMPGGVPVATMAIGEA
GATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSGELI

Sequences:

>Translated_203_residues
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIMGSKSDWATMQKTAEVLDNFGIAYEKKVVSA
HRTPDLMFKHAEEARGRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDLLYSIVQMPGGVPVATMAIGEA
GATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSGELI
>Mature_203_residues
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIMGSKSDWATMQKTAEVLDNFGIAYEKKVVSA
HRTPDLMFKHAEEARGRGIKIIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDLLYSIVQMPGGVPVATMAIGEA
GATNAALTALRILSIEDQNLADALAHFHEEQGKIAEESSGELI

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=63.6363636363636, Blast_Score=149, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=147, Percent_Identity=57.1428571428571, Blast_Score=158, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 22037; Mature: 22037

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIMGSKSDWATMQ
CHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCHHHHH
KTAEVLDNFGIAYEKKVVSAHRTPDLMFKHAEEARGRGIKIIIAGAGGAAHLPGMVAAKT
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCHHHHHC
TLPVIGVPVKSRALSGLDLLYSIVQMPGGVPVATMAIGEAGATNAALTALRILSIEDQNL
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHEEECCCCCH
ADALAHFHEEQGKIAEESSGELI
HHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLKHLVALTWVRLRNQRFRTYLIFFYGKFRQVETPLCILIMKTPIISIIMGSKSDWATMQ
CHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCHHHHH
KTAEVLDNFGIAYEKKVVSAHRTPDLMFKHAEEARGRGIKIIIAGAGGAAHLPGMVAAKT
HHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHCCCHHHHHC
TLPVIGVPVKSRALSGLDLLYSIVQMPGGVPVATMAIGEAGATNAALTALRILSIEDQNL
CCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHEEECCCCCH
ADALAHFHEEQGKIAEESSGELI
HHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]