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The map label for this gene is parE [H]

Identifier: 71893389

GI number: 71893389

Start: 36335

End: 38263

Strand: Reverse

Name: parE [H]

Synonym: MHJ_0030

Alternate gene names: 71893389

Gene position: 38263-36335 (Counterclockwise)

Preceding gene: 71893392

Following gene: 71893388

Centisome position: 4.26

GC content: 31.47

Gene sequence:

>1929_bases
ATGACCTACTCAGTAGAAAAATTAAAACTTTTAAAAGGGCTTGAAGCGGTCCGCAAACGCCCGGGAATGTATATTGGATC
AACTGATAAAAACGGATTACACCAGCTAATTTGGGAAATCTTTGATAATGCAATTGACGAGGCAATTGCTGGATTTGCAA
ATGAAATTTCACTAATAATTAATAGTGATAATTCTATTGAAATTAGTGATAATGGGCGCGGAATCCCGACAGAAATTCAT
AAAAAAACCGGAAAAACTGGCGTTGAATTAGTTTTTAGCGAGCTCCATTCAGGAGCGAAATTTTCTACTGATATCTACAA
AACCGCTGGTGGCCTTCATGGTGTTGGCTCTTCAGTTGTTAATGCTCTTTCTGAAAAACTAGAAGTCTATATAAATCGGG
ATAAAAAATTGTTCTATACTAGTTTTATTAACGGTGGAAAAATTGAAACTCGAACTAAAATTATAGGAAAAAGCGCTACA
ACTGGGACAAAAATCAGATTTTGACCTGATTTTTCCCTTTTTTCACATTCAGAATTTGACTCAGAAATGATAATTTCGCG
CCTACGCGAAACTTGTTTTTTGATTAACAATCTAAAAATCAATTTTTTTGATACAAAAAACAATATTGAAAAAAAGTTTC
TCTGCGAAAGGGGAATCGAAAGTTTTATTGAATTTTTGAACAATGATCAAGAAAAAATTCATGATAAAGTTATTACTTTT
AAAGAAAAAATGCAGGAAATCATAGTGGAATTTGGATTTCAGTATGTTAATTCACAGCAAGAAAATATTATCTCTTTTGT
CAATAATGTAAAAACAAATTTAGGGGGAAGTCACGAAAATGGTTTTAAATCCGGTTTTTTAAAGGCAATTAATACTTACG
GCCAACAAAATAATTTACTTAAAACTAAGCAAATTTTAGAATTTAGTGATGCAAAAGTTGGACTTTCAGCTGTTTTATCA
CTGCGAATTCCTGAATCAATTCTTGAATTTGTTGGGCAAACAAAAAATAAATTATCAACTATTTTAGCAAAAACAGTTAC
AGAAGAGGTAATTTTTACAAATTTAATGACTTTTTTTGCACTAAATAAAGAAGTTGCAAGTAAAATAATCAATTTTATAC
TAGAAACTTATACCCAAAGACAAAAGTCAAAATTAAGCATAATTGAGTCAAAAACAAGCAAATCAATTACAAAAGAAAAG
CGGATTTTATCAGGGAAATTAACCCCAGCAAATTCAAAAAAAGCTATGAATCGCGAGCTTTTTTTGGTTGAAGGTGAATC
GGCAGGTGGTTCTGCAAAACTTGCAAGAAACCGTGAGTTTCAAGCAATTTTACCTTTAAAAGGTAAAATTGTAAACGCCC
AAAAAACAAGATTAATTGATCTATTAAAAAATGAGGAAATTATCGCAATTATTAGTGCATTAGGAACTGGAATTGGCCAG
AATTTTAACCTTAAGAACCTAAATTATGGCAAAATTATCATTATGACTGACGCTGACAATGACGGAGCCCACATCCAAAT
TTTAATTTTAACCTTTCTTTTTTTGCATATGCGGCCTTTAATCGAAAAAGGTTTTGTCTATATTGCTCAACCGCCCTTAT
ATCGAATTAGTGAAAAGGGGAGAAAAGATATTTATATCTGGGATGAGGAAAAGTTCGAAAAATACATCAAAAACAGTACA
AATTTGCAAATTCAGCGCTATAAAGGACTTGGGGAAATGAATGCAAATCAGCTTTGGCAAACGACAATGGACCCCGAGAG
GCGAACTTTGGAAAAAGTTTTAATTGAAAATTATCCAAAAGTAGAGAAAAATTTTCAAATTTTAATGGGGGAAAGAGCTG
ATCTAAGAAAGAGCTGAATTGAAAAAAACGTTAATTTTTCCCTTGAAGACAAATTTATTGAAAATTTAAAGGAAACAATT
TATGAATAA

Upstream 100 bases:

>100_bases
TAAATTTTACATTAAAATTTTTGTAAAATTATTTACCTTTTTGTATAAAATTTAATTTAGAAAAATTTTTACGCATTTTC
AGAAAGGATTTAGACCCTAT

Downstream 100 bases:

>100_bases
AAGTCTTGATTCAGTAATTAATTCCCAGCTAGAAAAAATTTTAGCAGAAAAATTTATCCGTTATTCAAAATATGTAATTC
AACAACGGGCAATTCCAGAT

Product: topoisomerase IV subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MTYSVEKLKLLKGLEAVRKRPGMYIGSTDKNGLHQLIWEIFDNAIDEAIAGFANEISLIINSDNSIEISDNGRGIPTEIH
KKTGKTGVELVFSELHSGAKFSTDIYKTAGGLHGVGSSVVNALSEKLEVYINRDKKLFYTSFINGGKIETRTKIIGKSAT
TGTKIRFWPDFSLFSHSEFDSEMIISRLRETCFLINNLKINFFDTKNNIEKKFLCERGIESFIEFLNNDQEKIHDKVITF
KEKMQEIIVEFGFQYVNSQQENIISFVNNVKTNLGGSHENGFKSGFLKAINTYGQQNNLLKTKQILEFSDAKVGLSAVLS
LRIPESILEFVGQTKNKLSTILAKTVTEEVIFTNLMTFFALNKEVASKIINFILETYTQRQKSKLSIIESKTSKSITKEK
RILSGKLTPANSKKAMNRELFLVEGESAGGSAKLARNREFQAILPLKGKIVNAQKTRLIDLLKNEEIIAIISALGTGIGQ
NFNLKNLNYGKIIIMTDADNDGAHIQILILTFLFLHMRPLIEKGFVYIAQPPLYRISEKGRKDIYIWDEEKFEKYIKNST
NLQIQRYKGLGEMNANQLWQTTMDPERRTLEKVLIENYPKVEKNFQILMGERADLRKSWIEKNVNFSLEDKFIENLKETI
YE

Sequences:

>Translated_642_residues
MTYSVEKLKLLKGLEAVRKRPGMYIGSTDKNGLHQLIWEIFDNAIDEAIAGFANEISLIINSDNSIEISDNGRGIPTEIH
KKTGKTGVELVFSELHSGAKFSTDIYKTAGGLHGVGSSVVNALSEKLEVYINRDKKLFYTSFINGGKIETRTKIIGKSAT
TGTKIRF*PDFSLFSHSEFDSEMIISRLRETCFLINNLKINFFDTKNNIEKKFLCERGIESFIEFLNNDQEKIHDKVITF
KEKMQEIIVEFGFQYVNSQQENIISFVNNVKTNLGGSHENGFKSGFLKAINTYGQQNNLLKTKQILEFSDAKVGLSAVLS
LRIPESILEFVGQTKNKLSTILAKTVTEEVIFTNLMTFFALNKEVASKIINFILETYTQRQKSKLSIIESKTSKSITKEK
RILSGKLTPANSKKAMNRELFLVEGESAGGSAKLARNREFQAILPLKGKIVNAQKTRLIDLLKNEEIIAIISALGTGIGQ
NFNLKNLNYGKIIIMTDADNDGAHIQILILTFLFLHMRPLIEKGFVYIAQPPLYRISEKGRKDIYIWDEEKFEKYIKNST
NLQIQRYKGLGEMNANQLWQTTMDPERRTLEKVLIENYPKVEKNFQILMGERADLRKS*IEKNVNFSLEDKFIENLKETI
YE
>Mature_641_residues
TYSVEKLKLLKGLEAVRKRPGMYIGSTDKNGLHQLIWEIFDNAIDEAIAGFANEISLIINSDNSIEISDNGRGIPTEIHK
KTGKTGVELVFSELHSGAKFSTDIYKTAGGLHGVGSSVVNALSEKLEVYINRDKKLFYTSFINGGKIETRTKIIGKSATT
GTKIRF*PDFSLFSHSEFDSEMIISRLRETCFLINNLKINFFDTKNNIEKKFLCERGIESFIEFLNNDQEKIHDKVITFK
EKMQEIIVEFGFQYVNSQQENIISFVNNVKTNLGGSHENGFKSGFLKAINTYGQQNNLLKTKQILEFSDAKVGLSAVLSL
RIPESILEFVGQTKNKLSTILAKTVTEEVIFTNLMTFFALNKEVASKIINFILETYTQRQKSKLSIIESKTSKSITKEKR
ILSGKLTPANSKKAMNRELFLVEGESAGGSAKLARNREFQAILPLKGKIVNAQKTRLIDLLKNEEIIAIISALGTGIGQN
FNLKNLNYGKIIIMTDADNDGAHIQILILTFLFLHMRPLIEKGFVYIAQPPLYRISEKGRKDIYIWDEEKFEKYIKNSTN
LQIQRYKGLGEMNANQLWQTTMDPERRTLEKVLIENYPKVEKNFQILMGERADLRKS*IEKNVNFSLEDKFIENLKETIY
E

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=644, Percent_Identity=25.9316770186335, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI19913406, Length=633, Percent_Identity=25.1184834123223, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI48994957, Length=558, Percent_Identity=40.8602150537634, Blast_Score=427, Evalue=1e-120,
Organism=Escherichia coli, GI1789408, Length=603, Percent_Identity=34.9917081260365, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535065, Length=617, Percent_Identity=24.3111831442464, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI212645845, Length=552, Percent_Identity=25.5434782608696, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324241, Length=635, Percent_Identity=25.8267716535433, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17136538, Length=639, Percent_Identity=22.848200312989, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 72724; Mature: 72593

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSVEKLKLLKGLEAVRKRPGMYIGSTDKNGLHQLIWEIFDNAIDEAIAGFANEISLII
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NSDNSIEISDNGRGIPTEIHKKTGKTGVELVFSELHSGAKFSTDIYKTAGGLHGVGSSVV
ECCCEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHH
NALSEKLEVYINRDKKLFYTSFINGGKIETRTKIIGKSATTGTKIRFPDFSLFSHSEFDS
HHHHHHHHHEECCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCEEECCCCCCCCCCCCCH
EMIISRLRETCFLINNLKINFFDTKNNIEKKFLCERGIESFIEFLNNDQEKIHDKVITFK
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EKMQEIIVEFGFQYVNSQQENIISFVNNVKTNLGGSHENGFKSGFLKAINTYGQQNNLLK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHH
TKQILEFSDAKVGLSAVLSLRIPESILEFVGQTKNKLSTILAKTVTEEVIFTNLMTFFAL
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKEVASKIINFILETYTQRQKSKLSIIESKTSKSITKEKRILSGKLTPANSKKAMNRELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
LVEGESAGGSAKLARNREFQAILPLKGKIVNAQKTRLIDLLKNEEIIAIISALGTGIGQN
EEECCCCCCCCHHHCCCCCEEECCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
FNLKNLNYGKIIIMTDADNDGAHIQILILTFLFLHMRPLIEKGFVYIAQPPLYRISEKGR
CCCCCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCC
KDIYIWDEEKFEKYIKNSTNLQIQRYKGLGEMNANQLWQTTMDPERRTLEKVLIENYPKV
CCEEEECHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
EKNFQILMGERADLRKSIEKNVNFSLEDKFIENLKETIYE
CCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYSVEKLKLLKGLEAVRKRPGMYIGSTDKNGLHQLIWEIFDNAIDEAIAGFANEISLII
CCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NSDNSIEISDNGRGIPTEIHKKTGKTGVELVFSELHSGAKFSTDIYKTAGGLHGVGSSVV
ECCCEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHHHH
NALSEKLEVYINRDKKLFYTSFINGGKIETRTKIIGKSATTGTKIRFPDFSLFSHSEFDS
HHHHHHHHHEECCCCEEEEEECCCCCCEEHHHHHHCCCCCCCCEEECCCCCCCCCCCCCH
EMIISRLRETCFLINNLKINFFDTKNNIEKKFLCERGIESFIEFLNNDQEKIHDKVITFK
HHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EKMQEIIVEFGFQYVNSQQENIISFVNNVKTNLGGSHENGFKSGFLKAINTYGQQNNLLK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHH
TKQILEFSDAKVGLSAVLSLRIPESILEFVGQTKNKLSTILAKTVTEEVIFTNLMTFFAL
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKEVASKIINFILETYTQRQKSKLSIIESKTSKSITKEKRILSGKLTPANSKKAMNRELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEE
LVEGESAGGSAKLARNREFQAILPLKGKIVNAQKTRLIDLLKNEEIIAIISALGTGIGQN
EEECCCCCCCCHHHCCCCCEEECCCCCEEECHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
FNLKNLNYGKIIIMTDADNDGAHIQILILTFLFLHMRPLIEKGFVYIAQPPLYRISEKGR
CCCCCCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCC
KDIYIWDEEKFEKYIKNSTNLQIQRYKGLGEMNANQLWQTTMDPERRTLEKVLIENYPKV
CCEEEECHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
EKNFQILMGERADLRKSIEKNVNFSLEDKFIENLKETIYE
CCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7828871 [H]