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The map label for this gene is lpxA

Identifier: 71892065

GI number: 71892065

Start: 337500

End: 338288

Strand: Direct

Name: lpxA

Synonym: BPEN_291

Alternate gene names: 71892065

Gene position: 337500-338288 (Clockwise)

Preceding gene: 71892064

Following gene: 71892066

Centisome position: 42.63

GC content: 35.87

Gene sequence:

>789_bases
ATGATTCATCAATCTGCCATCATACATCCTAGTTCTATAATAGAAGAAGGAGCTATAATACACGATAACGTACATATCGG
TCCATTTTGTTTTATTGGAGCGCAAGTTGAAATAGGGGCGCGAACTTTACTGAAATCTCATATTGTAATTAATGGCATTA
CTCAAATTGGAGAAGATAATCAAATTTATCAATTTGCTTCTCTTGGGGAAGTGAACCAAGATTTAAAATACGCAAAAGAA
TCTACGCGCATAGAGATTGGTCATTATAATCAGATTAGAGAAAGTGTCACTATTCACCGAGGCACTATACAAGGCAAAAA
AGTTACCAAAATAGGAAATAGCAATTTATTTATGATTAACGTACATATTGCTCATGATTGCATAATAGGAGATCATTGTG
TCATGGCTAACAACGTTACCCTAGGAGGGCACGTAAGAGTAGATAATCACACTATTATTGGAGGAATGACCGCGATCCAT
CAATTTTGTATTATTGGAACACATGTTATGATTGGAGGATGTTCTGGTGTAGTTCAAGATATCCCGCCATTCATAATAGC
CCAAGGAAATCACGCAACACCTTTTGGATTAAACATTGAAGGTTTAAAACGGCGCGGTTTTAGTCGTTCCTCCGTACACG
CTATTCGAGATGCTTATAAAATTTTATATCGTAGCAGTAAAACTGTTGAATCAGCTAAAGAGGCTTTAAAAGCCTTAGCA
GCAGAACATCCAATTATCAATGAATTTGTAGATTTTTTAATACGCTCTCAACGAGGAATTATTCGTTAA

Upstream 100 bases:

>100_bases
AGACGTGGTATTGCACGCTTTAAAGGAATCGCTACAGTAAACGAAGAAATGGCTTGTGAAGCATCAATGATGTGCGCTCG
TAGAAAGGAAATTTAAACTG

Downstream 100 bases:

>100_bases
CAATGTCATCTATCGTCCCGTCCATGCATAATAATCGCACTATTATTATAGGTATAGTAGCAGGAGAAGCTTCTGGAGAT
ATTTTAGGAGCAGGACTAAT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDNQIYQFASLGEVNQDLKYAKE
STRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMINVHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIH
QFCIIGTHVMIGGCSGVVQDIPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALA
AEHPIINEFVDFLIRSQRGIIR

Sequences:

>Translated_262_residues
MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDNQIYQFASLGEVNQDLKYAKE
STRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMINVHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIH
QFCIIGTHVMIGGCSGVVQDIPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALA
AEHPIINEFVDFLIRSQRGIIR
>Mature_262_residues
MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDNQIYQFASLGEVNQDLKYAKE
STRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMINVHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIH
QFCIIGTHVMIGGCSGVVQDIPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALA
AEHPIINEFVDFLIRSQRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=66.030534351145, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1786376, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_BLOPB (Q493C0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277795.1
- ProteinModelPortal:   Q493C0
- SMR:   Q493C0
- STRING:   Q493C0
- GeneID:   3562928
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_291
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   CBLO291272:BPEN_291-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28790; Mature: 28790

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDN
CCCCCCEECHHHHHHCCCEEECCCEECCEEEEECEEEHHHHHHHHHHHEEEHHHHCCCCC
QIYQFASLGEVNQDLKYAKESTRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMIN
CEEEEHHCCCHHHHHHHHHHCCEEEECCHHHHHHHHEEEECCCCCCEEEEECCCCEEEEE
VHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIHQFCIIGTHVMIGGCSGVVQD
EEEEEEEEECCCEEEECCEEECCEEEECCEEEECHHHHHHHHHHHHCEEEEECCCCHHHH
IPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AEHPIINEFVDFLIRSQRGIIR
HCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIHQSAIIHPSSIIEEGAIIHDNVHIGPFCFIGAQVEIGARTLLKSHIVINGITQIGEDN
CCCCCCEECHHHHHHCCCEEECCCEECCEEEEECEEEHHHHHHHHHHHEEEHHHHCCCCC
QIYQFASLGEVNQDLKYAKESTRIEIGHYNQIRESVTIHRGTIQGKKVTKIGNSNLFMIN
CEEEEHHCCCHHHHHHHHHHCCEEEECCHHHHHHHHEEEECCCCCCEEEEECCCCEEEEE
VHIAHDCIIGDHCVMANNVTLGGHVRVDNHTIIGGMTAIHQFCIIGTHVMIGGCSGVVQD
EEEEEEEEECCCEEEECCEEECCEEEECCEEEECHHHHHHHHHHHHCEEEEECCCCHHHH
IPPFIIAQGNHATPFGLNIEGLKRRGFSRSSVHAIRDAYKILYRSSKTVESAKEALKALA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AEHPIINEFVDFLIRSQRGIIR
HCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA