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The map label for this gene is uppS [H]

Identifier: 71892058

GI number: 71892058

Start: 329804

End: 330556

Strand: Direct

Name: uppS [H]

Synonym: BPEN_284

Alternate gene names: 71892058

Gene position: 329804-330556 (Clockwise)

Preceding gene: 71892057

Following gene: 71892059

Centisome position: 41.66

GC content: 34.93

Gene sequence:

>753_bases
GTGATATTATCTCAACGTAATCAAGATCTTAGCACTTTTTCATCTAATTTATTACCACGCCATGTTGCTATTATCATGGA
TGGTAATGGGCGTTGGGCAAGAAGACGAGGAAAATTACGTATTGTTGGGCATCAAGCTGGATTTAATGCGGTACGGCGTG
CTGTTCATTTCGCTGTTAATTATAGATTCGATGCATTAACTTTATATGCGTTTAGCAGTGAAAACTGGAAACGTCCTGAC
AAAGAGATTGATTCTTTAATGCAATTGTTTTCTCATGCTTTAAATAATGAAATAGATGTTCTACATAAGAATAATATCAA
ACTAAGAATCATTGGAGATATTAATCGATTTTCCGGTGAATTACAAAAAAATATACACCGCTCTGAAAAATTAACTTCCA
ACAATAGTGGACTTACGCTTAATATTGCTGCAAATTATGGAGGACGATGGGATATTATCCAAGGAGTAAAACAACTTGCC
ACGCAAGTGCAGCAAGGAATATTAACCCCTAATCAAATTGACGAAGATGCTCTATGTAAATGTATCTGTATGCATGAATT
AGCTCCAGTAGATTTGGTGATTCGAACAGGAGGTGAACATCGCATTAGTAATTTTTTGCTTTGGCAAATAGCATATGCTG
AATTATTTTTTACAGATGTATTATGGCCTGATTTTAATGACGTCATATTTAAAAGAGCAGTAAATACTTTTATGAAACGA
GAGCGCCGATTTGGAAACAGCGCATCTATTTAA

Upstream 100 bases:

>100_bases
AATGATAAGTAATTTTATTAATCTATAATTATAATGTTAATTATTATAAACGAGTATTTTTACTTAACACAAAGGTATTT
AATTTGGAAAATAAATAAAT

Downstream 100 bases:

>100_bases
TTTTCAATACACATGTAATCAAGGAAAAAATGTGTTAAAAACCCGTTTAATTAGCATGTTGCTCCTTATCCCCATAACTA
TTTTGATGGTATTTTTATTG

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MILSQRNQDLSTFSSNLLPRHVAIIMDGNGRWARRRGKLRIVGHQAGFNAVRRAVHFAVNYRFDALTLYAFSSENWKRPD
KEIDSLMQLFSHALNNEIDVLHKNNIKLRIIGDINRFSGELQKNIHRSEKLTSNNSGLTLNIAANYGGRWDIIQGVKQLA
TQVQQGILTPNQIDEDALCKCICMHELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFNDVIFKRAVNTFMKR
ERRFGNSASI

Sequences:

>Translated_250_residues
MILSQRNQDLSTFSSNLLPRHVAIIMDGNGRWARRRGKLRIVGHQAGFNAVRRAVHFAVNYRFDALTLYAFSSENWKRPD
KEIDSLMQLFSHALNNEIDVLHKNNIKLRIIGDINRFSGELQKNIHRSEKLTSNNSGLTLNIAANYGGRWDIIQGVKQLA
TQVQQGILTPNQIDEDALCKCICMHELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFNDVIFKRAVNTFMKR
ERRFGNSASI
>Mature_250_residues
MILSQRNQDLSTFSSNLLPRHVAIIMDGNGRWARRRGKLRIVGHQAGFNAVRRAVHFAVNYRFDALTLYAFSSENWKRPD
KEIDSLMQLFSHALNNEIDVLHKNNIKLRIIGDINRFSGELQKNIHRSEKLTSNNSGLTLNIAANYGGRWDIIQGVKQLA
TQVQQGILTPNQIDEDALCKCICMHELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFNDVIFKRAVNTFMKR
ERRFGNSASI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=213, Percent_Identity=38.0281690140845, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI45580742, Length=213, Percent_Identity=38.0281690140845, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=67.9824561403509, Blast_Score=337, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI71993029, Length=218, Percent_Identity=34.4036697247706, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=34.5454545454545, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=217, Percent_Identity=31.3364055299539, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=35.4066985645933, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28695; Mature: 28695

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSQRNQDLSTFSSNLLPRHVAIIMDGNGRWARRRGKLRIVGHQAGFNAVRRAVHFAVN
CCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHE
YRFDALTLYAFSSENWKRPDKEIDSLMQLFSHALNNEIDVLHKNNIKLRIIGDINRFSGE
EEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCHHHHHH
LQKNIHRSEKLTSNNSGLTLNIAANYGGRWDIIQGVKQLATQVQQGILTPNQIDEDALCK
HHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
CICMHELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFNDVIFKRAVNTFMKR
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERRFGNSASI
HHHCCCCCCC
>Mature Secondary Structure
MILSQRNQDLSTFSSNLLPRHVAIIMDGNGRWARRRGKLRIVGHQAGFNAVRRAVHFAVN
CCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHE
YRFDALTLYAFSSENWKRPDKEIDSLMQLFSHALNNEIDVLHKNNIKLRIIGDINRFSGE
EEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEECCHHHHHH
LQKNIHRSEKLTSNNSGLTLNIAANYGGRWDIIQGVKQLATQVQQGILTPNQIDEDALCK
HHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
CICMHELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFNDVIFKRAVNTFMKR
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERRFGNSASI
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]