Definition Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome.
Accession NC_007292
Length 791,654

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The map label for this gene is dxr

Identifier: 71892057

GI number: 71892057

Start: 328454

End: 329647

Strand: Direct

Name: dxr

Synonym: BPEN_283

Alternate gene names: 71892057

Gene position: 328454-329647 (Clockwise)

Preceding gene: 71892056

Following gene: 71892058

Centisome position: 41.49

GC content: 34.67

Gene sequence:

>1194_bases
ATGCAATCTTTAACAATTTTAGGTAGTACTGGATCTATTGGAAAAGCTACCCTATCTGTAATACAACAACACACCGATAA
GTTCTTTGTGCATGCATTAGTCGCGAAAAATAACGTTGCTATCATGACAGAACAGTGCATAGCGATGTCTCCCAAATATG
CATGTATGATATCTGAAGATGCAGCACGAATATTGAAAAAAAATTTAATCACCGCTGGGAAATATGATATTGAAGTATTA
TCTGGGGTGATGCATGCCTGTGAATTAGCATCAACTAATGATGTGGATATGGTGATGTCTGCCATAGTTGGAATTGCTGG
ATTAAAGCCTACTTTTTCCGCGTTGCGTGCTGGTAAAAAAATATTATTGGCAAATAAAGAAACTTTAGTTACTGGCGGAA
AATTGTTTATGAAAGAAGCCAATCGATACCGTGCCTGTATACTGCCTATAGATAGCGAACATAACGCAATTTTTCAAAAT
CTACCAGAGATATGTCAGAAGAGTTTAGGAAATACATCTTTATCTGAATGCGGTATATCTCGTATTGTGCTAACTGCATC
TGGAGGAATTTTCTTCAAAACGCCACAAAAACAATTAACCAAAATAACACCAGAGCAGGCTTGTGTGCATCCTAATTGGT
CCATGGGGCGTAAGATATCAGTAGATTCTGCTACTATGATGAATAAGGGATTAGAATATATTGAAGCACGTCATTTATTT
AATGCTAAACCAAGTGAAATAGAAATTTTATTACATCCTCAGTCTATTGTCCATGCTATGGTATACTATTCCGACGGAAA
TGTATTGGCGCATTTAGCACCTCCAGATATGAGAATTCCTATTGCGTACGCAATGGCATATCCTAAAAGAATAGGACTAA
AAATCTCATCTAATATAGACATATATTATCTTAATAAATTACATTTTGATCAATTAGATAATTGCAGTTATCCTTGTTTT
CAATTAGCAATAGATGCTGATAATTGTAGTCAATCGGCTACTATTATCCTGAACGCAGCAAATGAAATCGCCGTAGAAGC
ATTTTTACGTAAAATGATTTCTTTTACTGACATTCCTGACGTCATTCGTCGTGTACTTGATGCAATAAATTTAAATGATC
CTAATGATATAGAAGATATTTTATATATTGATCAAAAAGCTCGTGAGAAAGCAATATCTATATGTGTCATATAA

Upstream 100 bases:

>100_bases
TTTTAAGTATTAAATTGTGCGTTGATAGATATTTATATATGTACTAACATAAATAATAGATTTTTATCTTTACACCCAAT
GAGTAATTTAATTTATACAT

Downstream 100 bases:

>100_bases
TAAATAATGTTGTCTTTAATAAATTTATCATAATTACTACATATATATATCGCGAAAATGATAAGTAATTTTATTAATCT
ATAATTATAATGTTAATTAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQSLTILGSTGSIGKATLSVIQQHTDKFFVHALVAKNNVAIMTEQCIAMSPKYACMISEDAARILKKNLITAGKYDIEVL
SGVMHACELASTNDVDMVMSAIVGIAGLKPTFSALRAGKKILLANKETLVTGGKLFMKEANRYRACILPIDSEHNAIFQN
LPEICQKSLGNTSLSECGISRIVLTASGGIFFKTPQKQLTKITPEQACVHPNWSMGRKISVDSATMMNKGLEYIEARHLF
NAKPSEIEILLHPQSIVHAMVYYSDGNVLAHLAPPDMRIPIAYAMAYPKRIGLKISSNIDIYYLNKLHFDQLDNCSYPCF
QLAIDADNCSQSATIILNAANEIAVEAFLRKMISFTDIPDVIRRVLDAINLNDPNDIEDILYIDQKAREKAISICVI

Sequences:

>Translated_397_residues
MQSLTILGSTGSIGKATLSVIQQHTDKFFVHALVAKNNVAIMTEQCIAMSPKYACMISEDAARILKKNLITAGKYDIEVL
SGVMHACELASTNDVDMVMSAIVGIAGLKPTFSALRAGKKILLANKETLVTGGKLFMKEANRYRACILPIDSEHNAIFQN
LPEICQKSLGNTSLSECGISRIVLTASGGIFFKTPQKQLTKITPEQACVHPNWSMGRKISVDSATMMNKGLEYIEARHLF
NAKPSEIEILLHPQSIVHAMVYYSDGNVLAHLAPPDMRIPIAYAMAYPKRIGLKISSNIDIYYLNKLHFDQLDNCSYPCF
QLAIDADNCSQSATIILNAANEIAVEAFLRKMISFTDIPDVIRRVLDAINLNDPNDIEDILYIDQKAREKAISICVI
>Mature_397_residues
MQSLTILGSTGSIGKATLSVIQQHTDKFFVHALVAKNNVAIMTEQCIAMSPKYACMISEDAARILKKNLITAGKYDIEVL
SGVMHACELASTNDVDMVMSAIVGIAGLKPTFSALRAGKKILLANKETLVTGGKLFMKEANRYRACILPIDSEHNAIFQN
LPEICQKSLGNTSLSECGISRIVLTASGGIFFKTPQKQLTKITPEQACVHPNWSMGRKISVDSATMMNKGLEYIEARHLF
NAKPSEIEILLHPQSIVHAMVYYSDGNVLAHLAPPDMRIPIAYAMAYPKRIGLKISSNIDIYYLNKLHFDQLDNCSYPCF
QLAIDADNCSQSATIILNAANEIAVEAFLRKMISFTDIPDVIRRVLDAINLNDPNDIEDILYIDQKAREKAISICVI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=54.4757033248082, Blast_Score=407, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_BLOPB (Q493C8)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277787.1
- ProteinModelPortal:   Q493C8
- SMR:   Q493C8
- STRING:   Q493C8
- GeneID:   3562592
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_283
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   CBLO291272:BPEN_283-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43729; Mature: 43729

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 153-153 BINDING 187-187 BINDING 210-210 BINDING 232-232

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MQSLTILGSTGSIGKATLSVIQQHTDKFFVHALVAKNNVAIMTEQCIAMSPKYACMISED
CCCEEEEECCCCCHHHHHHHHHHHHHHHHEEHEECCCCEEEEEHHHHHCCCCEEEEECHH
AARILKKNLITAGKYDIEVLSGVMHACELASTNDVDMVMSAIVGIAGLKPTFSALRAGKK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCE
ILLANKETLVTGGKLFMKEANRYRACILPIDSEHNAIFQNLPEICQKSLGNTSLSECGIS
EEEECCCEEEECCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCE
RIVLTASGGIFFKTPQKQLTKITPEQACVHPNWSMGRKISVDSATMMNKGLEYIEARHLF
EEEEEECCCEEEECCHHHHHHCCCHHHEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHC
NAKPSEIEILLHPQSIVHAMVYYSDGNVLAHLAPPDMRIPIAYAMAYPKRIGLKISSNID
CCCCCCEEEEECCHHHEEEEEEEECCCEEEEECCCCCCCCHHHHHHCHHHCCEEEECCEE
IYYLNKLHFDQLDNCSYPCFQLAIDADNCSQSATIILNAANEIAVEAFLRKMISFTDIPD
EEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCHHH
VIRRVLDAINLNDPNDIEDILYIDQKAREKAISICVI
HHHHHHHHCCCCCCCCHHHHHHHCHHHHHCCEEEEEC
>Mature Secondary Structure
MQSLTILGSTGSIGKATLSVIQQHTDKFFVHALVAKNNVAIMTEQCIAMSPKYACMISED
CCCEEEEECCCCCHHHHHHHHHHHHHHHHEEHEECCCCEEEEEHHHHHCCCCEEEEECHH
AARILKKNLITAGKYDIEVLSGVMHACELASTNDVDMVMSAIVGIAGLKPTFSALRAGKK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCE
ILLANKETLVTGGKLFMKEANRYRACILPIDSEHNAIFQNLPEICQKSLGNTSLSECGIS
EEEECCCEEEECCHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCE
RIVLTASGGIFFKTPQKQLTKITPEQACVHPNWSMGRKISVDSATMMNKGLEYIEARHLF
EEEEEECCCEEEECCHHHHHHCCCHHHEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHC
NAKPSEIEILLHPQSIVHAMVYYSDGNVLAHLAPPDMRIPIAYAMAYPKRIGLKISSNID
CCCCCCEEEEECCHHHEEEEEEEECCCEEEEECCCCCCCCHHHHHHCHHHCCEEEECCEE
IYYLNKLHFDQLDNCSYPCFQLAIDADNCSQSATIILNAANEIAVEAFLRKMISFTDIPD
EEEECCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCHHH
VIRRVLDAINLNDPNDIEDILYIDQKAREKAISICVI
HHHHHHHHCCCCCCCCHHHHHHHCHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA