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The map label for this gene is pyrG

Identifier: 71891944

GI number: 71891944

Start: 205130

End: 206776

Strand: Direct

Name: pyrG

Synonym: BPEN_161

Alternate gene names: 71891944

Gene position: 205130-206776 (Clockwise)

Preceding gene: 71891943

Following gene: 71891945

Centisome position: 25.91

GC content: 34.43

Gene sequence:

>1647_bases
GTGAGAGTGAATTATATTTTTGTAACTGGTGGAGTGGTATCATCTTTGGGTAAGGGCATTGCTACAGCATCTTTGGCTGC
AGTTTTAGAAGCGCGCGGTCTCAGTGTAACTATAATAAAATTAGACCCATATATCAATATGGACCCTGGTACAATTAGCC
CCGTACAACATGGAGAAGTGTTTATTACTGAAGATGGAGCAGAGACTGATTTAGACTTGGGGCATTATGAACGTTTTATC
CGTACTAAAATGAGACATCATAATAACTTTACTGCTGGTAAAATTTATGCTGATGTTTTACGGAAAGAGCGTCGAGGAGA
TTATTTAGGCGCTACGATACAGATTATTCCTCATGTCACTGACACTATAAAGAAGTGGCTTATAGCAGGCGCTTTTGGTC
ACGATGTGTTATTAGTAGAAATAGGTGGCACAGTAGGTGATATTGAATCATTGCCCTTTTTAGAGGCTATTAGGCAAATG
GTAATGGAAGTAAATAGAGAACAAACTTTATACATACATCTGACATTAGTGCCTTTTATTGCAGTATCTGGAGAACTAAA
AACTAAGCCAACACAACATTCAGTAAAAGAATTACTTTCTATTGGTATTCAACCTGACATTTTAATTTGCAGATCTGATC
GAGTAATCAGTAATAGTGAACGAAAAAAAATTTCTTTGTTTTGCAATGTACCTAAACAAGCGATAATTGCTCTGCAAGAT
GTAGATTCAATTTATAAAATACCTGCTTTACTTAAAGACCAAGGATTAGACAATTATATTTGTAAACGTTTTAATTTAAA
TTGTCCCGAGGCAAATCTATCAGATTGGGAGGAAGTAATTTATTATCAAGAACATCCGATAGGAGAAGTGACTGTTGGTA
TGGTAGGAAAATATATTGAATTGGTAGATGCTTACAAATCAGTGACAGAAGCATTAAAGCATGCTGGGATAAAAAATCGT
TTTATTGTGAATATTCGTCTTATTAACTCCCAAGATGTGGAAAAATTAGGTATAGAAAAAACACTGAAGGGTTTAGATGC
TATTTTAGTGCCTGGAGGATTTGGTTATCGCGGAGTGGAAGGAAAAATTTTATCCGCACAATATGCTCGAGAAAACAATA
TACCGTATTTTGGAATTTGCTTGGGTATGCAAGTAGCATTGATCGAATTTGCTCGTCATGTTGCTGGAATGCCAGAAGCC
AATTCTACAGAATTTGTAACTAATTGTAAATGCCCAGTAATAGCTTTAATAACTGAGTGTAAAGATGAGAATGGTATTTT
TATAACACACAATGATAATACTAATTTGGGCGGTACTATGCGCCTAGGTAATCAAGCGTGTTATTTAATTAAGGGGAGTT
TAACACATCAAATATATGGCAAAAGTACTATATTAGAACGTCATCGACATCGTTATGAAGTAAACAACATGTTATTAAAA
CATATAACACATGCTGGATTAAGTTGTGTTGGTTTTTCTAAAAAAAATAATTTAGTAGAAGTAATTGAATATCCAAATCA
TCCATGGTTTATAGGGAGTCAGTTCCATCCTGAATTTAATTCTACACCTCGTGAAGGTCATCCTTTATTTATAGGTTTTA
TAAAAGCTGCAATAGAGTACCAACATCGTCATAATAAATTAATTTAG

Upstream 100 bases:

>100_bases
ATACGCATATAATAATTACTTATTTAACTAATAATCCGCCATGATCATAGAGAAAAATTTTAAACCGTGAATAAATTAAA
TGTATAATTTAGGTTGATAT

Downstream 100 bases:

>100_bases
TACATACGAGTCAATGTTTATGATATTATTTTTTTGTTCGCATGAAAATCAAGATTAATTCACAAAGGAAATAAAAATGC
CTAAGATTTTAAATATTGTT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEVFITEDGAETDLDLGHYERFI
RTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVTDTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQM
VMEVNREQTLYIHLTLVPFIAVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQD
VDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIELVDAYKSVTEALKHAGIKNR
FIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVEGKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEA
NSTEFVTNCKCPVIALITECKDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLK
HITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEYQHRHNKLI

Sequences:

>Translated_548_residues
MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEVFITEDGAETDLDLGHYERFI
RTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVTDTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQM
VMEVNREQTLYIHLTLVPFIAVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQD
VDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIELVDAYKSVTEALKHAGIKNR
FIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVEGKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEA
NSTEFVTNCKCPVIALITECKDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLK
HITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEYQHRHNKLI
>Mature_548_residues
MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEVFITEDGAETDLDLGHYERFI
RTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVTDTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQM
VMEVNREQTLYIHLTLVPFIAVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQD
VDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIELVDAYKSVTEALKHAGIKNR
FIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVEGKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEA
NSTEFVTNCKCPVIALITECKDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLK
HITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEYQHRHNKLI

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=42.397137745975, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=559, Percent_Identity=42.5760286225402, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI28559083, Length=559, Percent_Identity=42.5760286225402, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI221316689, Length=559, Percent_Identity=42.5760286225402, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1789142, Length=546, Percent_Identity=73.6263736263736, Blast_Score=836, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=37.9310344827586, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322563, Length=567, Percent_Identity=40.3880070546737, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=38.8007054673721, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=41.6071428571429, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=40.0793650793651, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_BLOPB (Q493N6)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277674.1
- HSSP:   P0A7E5
- ProteinModelPortal:   Q493N6
- SMR:   Q493N6
- STRING:   Q493N6
- GeneID:   3563096
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_161
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   CBLO291272:BPEN_161-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 61302; Mature: 61302

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 380-380 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEV
CEEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FITEDGAETDLDLGHYERFIRTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHH
DTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQMVMEVNREQTLYIHLTLVPFI
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEHH
AVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQD
EECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCHHHHEEHHH
VDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIE
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHEECCCCCCEEHHHHHHHHHH
LVDAYKSVTEALKHAGIKNRFIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVE
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCC
GKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEANSTEFVTNCKCPVIALITEC
CEEEEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEHHHHC
KDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLK
CCCCCEEEEECCCCCCCCEEEECCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHH
HITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEY
HHHHCCCEEEEECCCCCEEEEEECCCCCEEECCEECCCCCCCCCCCCCEEHHHHHHHHHH
QHRHNKLI
HHHCCCCC
>Mature Secondary Structure
MRVNYIFVTGGVVSSLGKGIATASLAAVLEARGLSVTIIKLDPYINMDPGTISPVQHGEV
CEEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEE
FITEDGAETDLDLGHYERFIRTKMRHHNNFTAGKIYADVLRKERRGDYLGATIQIIPHVT
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHH
DTIKKWLIAGAFGHDVLLVEIGGTVGDIESLPFLEAIRQMVMEVNREQTLYIHLTLVPFI
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEHH
AVSGELKTKPTQHSVKELLSIGIQPDILICRSDRVISNSERKKISLFCNVPKQAIIALQD
EECCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCHHHHEEHHH
VDSIYKIPALLKDQGLDNYICKRFNLNCPEANLSDWEEVIYYQEHPIGEVTVGMVGKYIE
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHEECCCCCCEEHHHHHHHHHH
LVDAYKSVTEALKHAGIKNRFIVNIRLINSQDVEKLGIEKTLKGLDAILVPGGFGYRGVE
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCC
GKILSAQYARENNIPYFGICLGMQVALIEFARHVAGMPEANSTEFVTNCKCPVIALITEC
CEEEEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCEEHHHHC
KDENGIFITHNDNTNLGGTMRLGNQACYLIKGSLTHQIYGKSTILERHRHRYEVNNMLLK
CCCCCEEEEECCCCCCCCEEEECCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHH
HITHAGLSCVGFSKKNNLVEVIEYPNHPWFIGSQFHPEFNSTPREGHPLFIGFIKAAIEY
HHHHCCCEEEEECCCCCEEEEEECCCCCEEECCEECCCCCCCCCCCCCEEHHHHHHHHHH
QHRHNKLI
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA