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The map label for this gene is murC

Identifier: 71891930

GI number: 71891930

Start: 180099

End: 181541

Strand: Direct

Name: murC

Synonym: BPEN_147

Alternate gene names: 71891930

Gene position: 180099-181541 (Clockwise)

Preceding gene: 71891929

Following gene: 71891931

Centisome position: 22.75

GC content: 34.03

Gene sequence:

>1443_bases
ATGTCAGGCATACTATTATCTAACCCGGTCAATGCTATACCATTGATGAATCGTATTAGGAAAATACATTTTGTTGGTAT
AGGCGGAACCGGAATGTGTGGAATTGCAGAAATATTGGCACATGAAGGTTATTGTATTACTGGGTCTGATATTGTATATA
GTAGCACGACACGGCACTTATTTGAATTAGGGGTGAAAATCTTTATTGGACATAAATATAGTAATATAAACAACGCCAAT
GTTATTGTTGTATCCAGCGCTATTCACCCAAATAATCCTGAAATTTTAGCTGCTAAACAAGCTCGTATTCCCGTTATTAA
GCGTGCGGAAATGTTATCCGAACTAATGAGATTTAGACATGGAATAGCTATTTCTGGAACGCATGGGAAAACTACTACTA
CTACAATGATAGTTAATATCTATACTGCAGCAGGATTAGATCCAACGTTTATAAACGGAGGCATAGTCAAATCAGAAGGT
GTGCATGCTCGGCTTGGATATAGTCGTTATTTAATCGTAGAAGCAGATGAAAGTGATAATTCATTTTTGCATTTGCATCC
TATGGTGGAGGTGATTACCAATATTGATACTGACCATATACATGAGTATCAAGGAAATTTTGAATATCTTAAAAAAGCAT
TTATTGATTTTTTACACAACCTACCATTTTATGGGTATGCTATAGTGTGTATTGATGATCCAGTAATTTGTGAGATTTTA
CCTAAAATTAAAAGGAAGATAATCACTTATGGTTTTAATAAAAATGCTAATTTGCATATTTTTAATTATCGTCAACATAT
AGAAAAAAGTAGTTTTACCGTATCGCGTTTCAATCAAACAAAACTACAGGTTACTTTAAATGCCCCTGGTTGTCATAATG
CGTTGAATGCTACAGCTGCTATTGCAGTAGCAACTGAAGAAGGAATCAGTGATAAAATTATTCTCAAAACTATGTTGGAT
TTTCAAGGAACACATCGCCGTTTTGAAAATTTAGGTTATTATTCTTTAAATAAAATAAATGACCAAACAGGAGAAATTCT
GTTGATAGATGATTATGGACATCATCCGGCTGAGTTACATGCTACTATTGTAGCGATCCGGACCGGATGGCCTGATAGAC
GGTTGGTTATGGTATTTCAACCTCATCGATATACGCGTATAAAAGAATTGTATTATGATTTTATTGATGTACTTTCTAAT
GTAGATATTCTTTTGATATTACATGTTTATTCCGCTGGGGAACCACCTATTTTAGGAGCAGATAGTCAATCCTTATGTCA
TGCAATTCGTGAATTTGGTAAGATTAATCCAACATTTATATCAAATACGAAAATGTTATCAGGAGCGTTATTCAGACTCT
TAAGAAATAACGATTTGCTCTTAATTCAAGGAGCTGGTACAATAGGGGAGGTTGTGCGTAGATTAATTGTTAAAAACGAT
TAA

Upstream 100 bases:

>100_bases
CAACAAGTTTCCCAAGTAATCATTGAATACTTAAAAAAATAAATATATTAATAATGTCATCTTTATAAATAGAAAAATAT
TGAAAGTATATTGAATAGAT

Downstream 100 bases:

>100_bases
TCATAAATATATGATAATTATGATTCTTAATGATACGAAATGACAGAATGTAAAAACGAAACACAATAATAAATTTTTAT
GAAAATAAGAATACGCAAAG

Product: UDP-N-acetyl-muramate:alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSGILLSNPVNAIPLMNRIRKIHFVGIGGTGMCGIAEILAHEGYCITGSDIVYSSTTRHLFELGVKIFIGHKYSNINNAN
VIVVSSAIHPNNPEILAAKQARIPVIKRAEMLSELMRFRHGIAISGTHGKTTTTTMIVNIYTAAGLDPTFINGGIVKSEG
VHARLGYSRYLIVEADESDNSFLHLHPMVEVITNIDTDHIHEYQGNFEYLKKAFIDFLHNLPFYGYAIVCIDDPVICEIL
PKIKRKIITYGFNKNANLHIFNYRQHIEKSSFTVSRFNQTKLQVTLNAPGCHNALNATAAIAVATEEGISDKIILKTMLD
FQGTHRRFENLGYYSLNKINDQTGEILLIDDYGHHPAELHATIVAIRTGWPDRRLVMVFQPHRYTRIKELYYDFIDVLSN
VDILLILHVYSAGEPPILGADSQSLCHAIREFGKINPTFISNTKMLSGALFRLLRNNDLLLIQGAGTIGEVVRRLIVKND

Sequences:

>Translated_480_residues
MSGILLSNPVNAIPLMNRIRKIHFVGIGGTGMCGIAEILAHEGYCITGSDIVYSSTTRHLFELGVKIFIGHKYSNINNAN
VIVVSSAIHPNNPEILAAKQARIPVIKRAEMLSELMRFRHGIAISGTHGKTTTTTMIVNIYTAAGLDPTFINGGIVKSEG
VHARLGYSRYLIVEADESDNSFLHLHPMVEVITNIDTDHIHEYQGNFEYLKKAFIDFLHNLPFYGYAIVCIDDPVICEIL
PKIKRKIITYGFNKNANLHIFNYRQHIEKSSFTVSRFNQTKLQVTLNAPGCHNALNATAAIAVATEEGISDKIILKTMLD
FQGTHRRFENLGYYSLNKINDQTGEILLIDDYGHHPAELHATIVAIRTGWPDRRLVMVFQPHRYTRIKELYYDFIDVLSN
VDILLILHVYSAGEPPILGADSQSLCHAIREFGKINPTFISNTKMLSGALFRLLRNNDLLLIQGAGTIGEVVRRLIVKND
>Mature_479_residues
SGILLSNPVNAIPLMNRIRKIHFVGIGGTGMCGIAEILAHEGYCITGSDIVYSSTTRHLFELGVKIFIGHKYSNINNANV
IVVSSAIHPNNPEILAAKQARIPVIKRAEMLSELMRFRHGIAISGTHGKTTTTTMIVNIYTAAGLDPTFINGGIVKSEGV
HARLGYSRYLIVEADESDNSFLHLHPMVEVITNIDTDHIHEYQGNFEYLKKAFIDFLHNLPFYGYAIVCIDDPVICEILP
KIKRKIITYGFNKNANLHIFNYRQHIEKSSFTVSRFNQTKLQVTLNAPGCHNALNATAAIAVATEEGISDKIILKTMLDF
QGTHRRFENLGYYSLNKINDQTGEILLIDDYGHHPAELHATIVAIRTGWPDRRLVMVFQPHRYTRIKELYYDFIDVLSNV
DILLILHVYSAGEPPILGADSQSLCHAIREFGKINPTFISNTKMLSGALFRLLRNNDLLLIQGAGTIGEVVRRLIVKND

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=59.1792656587473, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1790680, Length=474, Percent_Identity=24.0506329113924, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BLOPB (Q493Q0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277660.1
- ProteinModelPortal:   Q493Q0
- SMR:   Q493Q0
- STRING:   Q493Q0
- GeneID:   3562869
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_147
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- BioCyc:   CBLO291272:BPEN_147-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53718; Mature: 53587

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGILLSNPVNAIPLMNRIRKIHFVGIGGTGMCGIAEILAHEGYCITGSDIVYSSTTRHL
CCCCEECCCCCHHHHHHHCEEEEEEEECCCCHHHHHHHHHCCCEEEECCCEEECCHHHHH
FELGVKIFIGHKYSNINNANVIVVSSAIHPNNPEILAAKQARIPVIKRAEMLSELMRFRH
HHCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAISGTHGKTTTTTMIVNIYTAAGLDPTFINGGIVKSEGVHARLGYSRYLIVEADESDN
CEEEECCCCCCEEEEEEEEEEEECCCCCCEECCCEEECCCCEEEECCEEEEEEEECCCCC
SFLHLHPMVEVITNIDTDHIHEYQGNFEYLKKAFIDFLHNLPFYGYAIVCIDDPVICEIL
CEEEEHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
PKIKRKIITYGFNKNANLHIFNYRQHIEKSSFTVSRFNQTKLQVTLNAPGCHNALNATAA
HHHHHHHEEECCCCCCCEEEEEHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCCEEE
IAVATEEGISDKIILKTMLDFQGTHRRFENLGYYSLNKINDQTGEILLIDDYGHHPAELH
EEEEECCCCCCHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCEEE
ATIVAIRTGWPDRRLVMVFQPHRYTRIKELYYDFIDVLSNVDILLILHVYSAGEPPILGA
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEECC
DSQSLCHAIREFGKINPTFISNTKMLSGALFRLLRNNDLLLIQGAGTIGEVVRRLIVKND
CCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGILLSNPVNAIPLMNRIRKIHFVGIGGTGMCGIAEILAHEGYCITGSDIVYSSTTRHL
CCCEECCCCCHHHHHHHCEEEEEEEECCCCHHHHHHHHHCCCEEEECCCEEECCHHHHH
FELGVKIFIGHKYSNINNANVIVVSSAIHPNNPEILAAKQARIPVIKRAEMLSELMRFRH
HHCCEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAISGTHGKTTTTTMIVNIYTAAGLDPTFINGGIVKSEGVHARLGYSRYLIVEADESDN
CEEEECCCCCCEEEEEEEEEEEECCCCCCEECCCEEECCCCEEEECCEEEEEEEECCCCC
SFLHLHPMVEVITNIDTDHIHEYQGNFEYLKKAFIDFLHNLPFYGYAIVCIDDPVICEIL
CEEEEHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHH
PKIKRKIITYGFNKNANLHIFNYRQHIEKSSFTVSRFNQTKLQVTLNAPGCHNALNATAA
HHHHHHHEEECCCCCCCEEEEEHHHHHCCCCCEEEECCCEEEEEEECCCCCCCCCCCEEE
IAVATEEGISDKIILKTMLDFQGTHRRFENLGYYSLNKINDQTGEILLIDDYGHHPAELH
EEEEECCCCCCHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCEEE
ATIVAIRTGWPDRRLVMVFQPHRYTRIKELYYDFIDVLSNVDILLILHVYSAGEPPILGA
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEECC
DSQSLCHAIREFGKINPTFISNTKMLSGALFRLLRNNDLLLIQGAGTIGEVVRRLIVKND
CCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA