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The map label for this gene is lspA

Identifier: 71891906

GI number: 71891906

Start: 148935

End: 149432

Strand: Direct

Name: lspA

Synonym: BPEN_123

Alternate gene names: 71891906

Gene position: 148935-149432 (Clockwise)

Preceding gene: 71891905

Following gene: 71891907

Centisome position: 18.81

GC content: 26.31

Gene sequence:

>498_bases
ATGAATAATAAATATAATTATAAAAATTTAAAATGGTTATGGTTGTCTATATTAATAATGTTATTAGACATAGGAACAAA
GTATTGGGTAAAGACTCATTTTTGGATTGGTGAGGTATTATCAGTATTACCTGGAATTAATTGTTATTATGTTTGTAATC
CAGGATTAGCTTTTGGGTTATTTACTAATGCTAGTTTATATTATCGTTGGCTATTTGTGTGGATAATAACATTAGTAATT
GTAGCGTTTATCATAGCTTTATATAAATTGATTGAACGCCCAAAATGTTATAGTATATCCTACTCTATGGTTATTGGAGG
GGCATTAGGAAATTTATTGGATCGAATATTATACGGAGCAGTAGTTGATTTTATTGATGTTCACATTAAAAATTGGCATT
GGCCAACTTTTAATGTTGCAGATATAGCAATTTGTATAGGAATTACTATTGTAACAATAAGATTCTATTATGATTTTATT
AAAAATAATTTATATTAG

Upstream 100 bases:

>100_bases
ATTATAGATTAGATATTGGTCAATATAAAAATTATTCAAATATTTGTGCACGTTGTGTCAACAACATAGTTGGACCAGGG
GAAAAACGTAGGTTTTTTTA

Downstream 100 bases:

>100_bases
AATCGTGATATGTATAATGATTATTATCAATATAATATGCACTATTATGTTTATTAATCTAATTACAAAATTACTAAAAA
TTAATTGTCACATTTTATGT

Product: prolipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MNNKYNYKNLKWLWLSILIMLLDIGTKYWVKTHFWIGEVLSVLPGINCYYVCNPGLAFGLFTNASLYYRWLFVWIITLVI
VAFIIALYKLIERPKCYSISYSMVIGGALGNLLDRILYGAVVDFIDVHIKNWHWPTFNVADIAICIGITIVTIRFYYDFI
KNNLY

Sequences:

>Translated_165_residues
MNNKYNYKNLKWLWLSILIMLLDIGTKYWVKTHFWIGEVLSVLPGINCYYVCNPGLAFGLFTNASLYYRWLFVWIITLVI
VAFIIALYKLIERPKCYSISYSMVIGGALGNLLDRILYGAVVDFIDVHIKNWHWPTFNVADIAICIGITIVTIRFYYDFI
KNNLY
>Mature_165_residues
MNNKYNYKNLKWLWLSILIMLLDIGTKYWVKTHFWIGEVLSVLPGINCYYVCNPGLAFGLFTNASLYYRWLFVWIITLVI
VAFIIALYKLIERPKCYSISYSMVIGGALGNLLDRILYGAVVDFIDVHIKNWHWPTFNVADIAICIGITIVTIRFYYDFI
KNNLY

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=156, Percent_Identity=35.2564102564103, Blast_Score=125, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_BLOPB (Q493S2)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277636.1
- STRING:   Q493S2
- MEROPS:   A08.001
- GeneID:   3563126
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_123
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   DIHINDW
- BioCyc:   CBLO291272:BPEN_123-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19343; Mature: 19343

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x1134dd24)-; HASH(0x10b3b238)-; HASH(0x10b30e1c)-; HASH(0x10b476c4)-; HASH(0x10b455a4)-;

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKYNYKNLKWLWLSILIMLLDIGTKYWVKTHFWIGEVLSVLPGINCYYVCNPGLAFGL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHH
FTNASLYYRWLFVWIITLVIVAFIIALYKLIERPKCYSISYSMVIGGALGNLLDRILYGA
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
VVDFIDVHIKNWHWPTFNVADIAICIGITIVTIRFYYDFIKNNLY
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MNNKYNYKNLKWLWLSILIMLLDIGTKYWVKTHFWIGEVLSVLPGINCYYVCNPGLAFGL
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHH
FTNASLYYRWLFVWIITLVIVAFIIALYKLIERPKCYSISYSMVIGGALGNLLDRILYGA
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
VVDFIDVHIKNWHWPTFNVADIAICIGITIVTIRFYYDFIKNNLY
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA