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The map label for this gene is metC [H]

Identifier: 71891857

GI number: 71891857

Start: 81475

End: 82662

Strand: Reverse

Name: metC [H]

Synonym: BPEN_069

Alternate gene names: 71891857

Gene position: 82662-81475 (Counterclockwise)

Preceding gene: 71891858

Following gene: 71891853

Centisome position: 10.44

GC content: 33.42

Gene sequence:

>1188_bases
ATGAAAAAATTTGAAACTACACTAATTACTTCTGGAAGAGAACAGAAATATACATACGGCGCAATTAATCCTATTATCCA
ACGAACATCTTCAGTAGTATTCAATTCTATTCAGCAAAAACAGAAAGCTGTAAATAATCATAGTACAACTGATAAATTAT
TCTATGGTCGATATGGAACTATTACTCATTTTTCCCTACGCCAATCAATGACTGAATTAGAAAATGGTGTTGGTTGCATG
CTATATCCATGCGGTACAGCGGCAATTACTCATACGATCCTTTCTTTTGTCCAACCAGGAGACCATATATTGATGACAGG
ATCTGCATATGAACCAACTCAGAAATTCTGTCGATATGTTTTAAAGAGAATGAATATAGACACTACCTGGTTTGATCCAT
TAATTGGAAATAATATTTCTAATTTAATTCAACATAATACTCGTTTAGTTATATTAGAATCACCAGGATCAATAACAATG
GAGGTGCAAGATGTTCCTAGCATCGTTAAAACAGTACGTAAAAAAAAATCAGATATTATCATATTACTAGACAATACTTG
GTCAGCAGGAGTTTTTTTAAAAGCATTAGATATCGGAGTAGATGTTTCTCTACAATCAGGTACTAAATATATCATAGGCC
ATTCTGATGGAATGATAGGAACTGCAGTTTCTAACGCACGTTGTTGGGATCAATTACAAGAACAATCTTATTTAATGGGA
CAAATGGTTGATGCTGACACCGCTTACATGGCATCACGTGGATTACGCACTTTATATGTTAGATTAAAACAACATGAAGA
AAATGGACTACATGTTGCTCATTGGTTAGCTCAACACCCAAAAATAGAGCGAGTCAATCATCCCGCTTTATCTACATGCA
AAGGACATAAATATTTTATAAGAGATTTTAGTGGATCTAGCGGATTATTTTCATTTATTTTAAAGAACCGTTTAAATGAT
TTACAATTATCTAATTTTATTGATCATTTTAAATACTTTAAAATTGCATATTCCTGGGGCGGATTTGAATCTTTAATTTT
AGTTAATCAAGTAGAAGAACTACGTCCTATACGCCCTTCTGGTGCGTTAGATTTTACAGGAACATTAGTTCGAATTCACG
TGGGATTAGAACACCCTAATGATCTGATTCATGATTTATCGGATGCTCTTAACCGCATAAATGCATAG

Upstream 100 bases:

>100_bases
TATAAACATATTAAAATAATACCAATAAAAATATAATATTTGTTGTATAACATATCAAATATATTTAGTTTTTATTATTA
GTCCATTCAATACAACAATC

Downstream 100 bases:

>100_bases
TGACATAAATAACTTTAACGTTCAAAAATATTTGTATCTTTATACATTAATCGCAAAAGTATCTAATCAATAATTAGATA
TACATATCCGTAATTTTTAC

Product: beta-cystathionase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKKFETTLITSGREQKYTYGAINPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGTITHFSLRQSMTELENGVGCM
LYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYVLKRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITM
EVQDVPSIVKTVRKKKSDIIILLDNTWSAGVFLKALDIGVDVSLQSGTKYIIGHSDGMIGTAVSNARCWDQLQEQSYLMG
QMVDADTAYMASRGLRTLYVRLKQHEENGLHVAHWLAQHPKIERVNHPALSTCKGHKYFIRDFSGSSGLFSFILKNRLND
LQLSNFIDHFKYFKIAYSWGGFESLILVNQVEELRPIRPSGALDFTGTLVRIHVGLEHPNDLIHDLSDALNRINA

Sequences:

>Translated_395_residues
MKKFETTLITSGREQKYTYGAINPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGTITHFSLRQSMTELENGVGCM
LYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYVLKRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITM
EVQDVPSIVKTVRKKKSDIIILLDNTWSAGVFLKALDIGVDVSLQSGTKYIIGHSDGMIGTAVSNARCWDQLQEQSYLMG
QMVDADTAYMASRGLRTLYVRLKQHEENGLHVAHWLAQHPKIERVNHPALSTCKGHKYFIRDFSGSSGLFSFILKNRLND
LQLSNFIDHFKYFKIAYSWGGFESLILVNQVEELRPIRPSGALDFTGTLVRIHVGLEHPNDLIHDLSDALNRINA
>Mature_395_residues
MKKFETTLITSGREQKYTYGAINPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGTITHFSLRQSMTELENGVGCM
LYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYVLKRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITM
EVQDVPSIVKTVRKKKSDIIILLDNTWSAGVFLKALDIGVDVSLQSGTKYIIGHSDGMIGTAVSNARCWDQLQEQSYLMG
QMVDADTAYMASRGLRTLYVRLKQHEENGLHVAHWLAQHPKIERVNHPALSTCKGHKYFIRDFSGSSGLFSFILKNRLND
LQLSNFIDHFKYFKIAYSWGGFESLILVNQVEELRPIRPSGALDFTGTLVRIHVGLEHPNDLIHDLSDALNRINA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=381, Percent_Identity=29.6587926509186, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI299473759, Length=381, Percent_Identity=27.0341207349081, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI25453487, Length=380, Percent_Identity=26.3157894736842, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=60.2040816326531, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1790375, Length=398, Percent_Identity=27.1356783919598, Blast_Score=141, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17538055, Length=330, Percent_Identity=32.1212121212121, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=340, Percent_Identity=31.4705882352941, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71980708, Length=375, Percent_Identity=30.1333333333333, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=38.3928571428571, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319307, Length=400, Percent_Identity=30.25, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=254, Percent_Identity=29.1338582677165, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323333, Length=394, Percent_Identity=24.1116751269036, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=260, Percent_Identity=29.2307692307692, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922554, Length=392, Percent_Identity=32.1428571428571, Blast_Score=187, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44558; Mature: 44558

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFETTLITSGREQKYTYGAINPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGT
CCCCCCEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
ITHFSLRQSMTELENGVGCMLYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYV
EEHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
LKRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITMEVQDVPSIVKTVRKKKSDII
HHHCCCCCCCCCHHHCCCHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHCCCCEE
ILLDNTWSAGVFLKALDIGVDVSLQSGTKYIIGHSDGMIGTAVSNARCWDQLQEQSYLMG
EEEECCCCCCEEEEEEECCEEEEECCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
QMVDADTAYMASRGLRTLYVRLKQHEENGLHVAHWLAQHPKIERVNHPALSTCKGHKYFI
HHCCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCEEEE
RDFSGSSGLFSFILKNRLNDLQLSNFIDHFKYFKIAYSWGGFESLILVNQVEELRPIRPS
EECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCC
GALDFTGTLVRIHVGLEHPNDLIHDLSDALNRINA
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKFETTLITSGREQKYTYGAINPIIQRTSSVVFNSIQQKQKAVNNHSTTDKLFYGRYGT
CCCCCCEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCC
ITHFSLRQSMTELENGVGCMLYPCGTAAITHTILSFVQPGDHILMTGSAYEPTQKFCRYV
EEHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHH
LKRMNIDTTWFDPLIGNNISNLIQHNTRLVILESPGSITMEVQDVPSIVKTVRKKKSDII
HHHCCCCCCCCCHHHCCCHHHHHHCCCEEEEEECCCCEEEEHHHHHHHHHHHHHCCCCEE
ILLDNTWSAGVFLKALDIGVDVSLQSGTKYIIGHSDGMIGTAVSNARCWDQLQEQSYLMG
EEEECCCCCCEEEEEEECCEEEEECCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHHH
QMVDADTAYMASRGLRTLYVRLKQHEENGLHVAHWLAQHPKIERVNHPALSTCKGHKYFI
HHCCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHCCCCEEEE
RDFSGSSGLFSFILKNRLNDLQLSNFIDHFKYFKIAYSWGGFESLILVNQVEELRPIRPS
EECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCC
GALDFTGTLVRIHVGLEHPNDLIHDLSDALNRINA
CCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]