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The map label for this gene is cysY [C]

Identifier: 68537076

GI number: 68537076

Start: 2308904

End: 2310049

Strand: Direct

Name: cysY [C]

Synonym: jk1981

Alternate gene names: 68537076

Gene position: 2308904-2310049 (Clockwise)

Preceding gene: 68537075

Following gene: 68537077

Centisome position: 93.76

GC content: 62.91

Gene sequence:

>1146_bases
ATGAAAATCTCAACTCGCACTACCCACTCAGCGATGAGCGGCGCGGGCGGCGAGTCGGCGCACCCTGCCGTGTGCACGGT
TGCCCCGCCGCGCGTCAGCACCAAAATCTGCGACCTGATCGGCAACACACCCGCACTGGAGCTTTGCCGCACAGGCACCG
GAAGCCGACTCATCCTCAAATTGGACTGCTTCAATCCCACCGGGAGCGTCAAAATCCGCATGGCGATGGAAATGGTGCAA
GGCGCCGAGCGTGCCGGGCTCTTGCGCCCGGGTAGCCGGATCGTTGAACCCACCTCGGGAAACACAGGACTTGGCCTGGC
TATCGCGGCCTCCCAGCGCGGGTACAGATTTACCGCAGTGGTGGATCATCATGCCGCCAAAGACAAACTCGATGCCATGC
GTGCCCTCGGTGCCGAGCTGATTTTCGTCGGCTCACCGGACACGAGCAAGCCATCCACCGTAGCCCGGCGGAGCATGGCG
AAGCACATCGTCGAATCCGACCCGAACGCCTGGTGGCCCGACCAACACAACAACCCGGACAACCCGGGCGGATATGCACA
GCTCGCGCACGAGCTTTCCGCCCAATGTTCGGACGGCGTGGACGTGCTCGTCGCCGCCGTAGGCACGGGCGGCACCCTCT
GCGGAACCACACGTGAACTTCGAAGGATGGGCCACGAGGCAAAAACGGTGGGCGTCGAGCCAGAAGGATCCATCATTTTC
GGAGGACCGGCTGGCTCCTACAAACAGTCCGGCGCGGGTGCTCCCGGCGGCTTCACTATCGGGCAGAACGTGGATTATGC
CCTAATCGATCAGCAGATCAAGGTAGGCGACGTCAAGGCATTCGCCACCTCGCGCGTACTCGCCCGGCGACACGGACTAA
TGGTTGGAGGAACTGCCGGGGCAGCAGTCCATGAGGGGCTGCAGACCTTGCAGACCTGCGCCGCGAACAGCACTGTTGTA
GTGCTTGTTTGCGACGCTGGGGAGAAATACCTGGACACAGTGTTTAACGACGCATGGTTGGATAGCCACGGGCTGCGCTC
CGAGATCGCAGAGCGGCACGTGGAGAACATGCTGCGCGCCTACCGCGATTCGCGTTCCTTGTGCGCCGGCTGCCAGGCGC
CACGATGCAGCGCGGTGCGGAGATGA

Upstream 100 bases:

>100_bases
CTACCGCTCCCCAGCCGCTTCGTCTGGGATAGCTCAGTCCCCACCATTCGTCATGATCACCCCCTGCATGTGGAACTCTG
AAAGGCTATTGGCACGTTCC

Downstream 100 bases:

>100_bases
GGGTGGCTGCGAGGTTGAACTCCATTCAGAAGTACCGCGAAGTCCTTGGAATTTCCCTTCCCATCGCCGGGGTGCAGCTC
GCCGGGGTGGCGCTGACCAC

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKISTRTTHSAMSGAGGESAHPAVCTVAPPRVSTKICDLIGNTPALELCRTGTGSRLILKLDCFNPTGSVKIRMAMEMVQ
GAERAGLLRPGSRIVEPTSGNTGLGLAIAASQRGYRFTAVVDHHAAKDKLDAMRALGAELIFVGSPDTSKPSTVARRSMA
KHIVESDPNAWWPDQHNNPDNPGGYAQLAHELSAQCSDGVDVLVAAVGTGGTLCGTTRELRRMGHEAKTVGVEPEGSIIF
GGPAGSYKQSGAGAPGGFTIGQNVDYALIDQQIKVGDVKAFATSRVLARRHGLMVGGTAGAAVHEGLQTLQTCAANSTVV
VLVCDAGEKYLDTVFNDAWLDSHGLRSEIAERHVENMLRAYRDSRSLCAGCQAPRCSAVRR

Sequences:

>Translated_381_residues
MKISTRTTHSAMSGAGGESAHPAVCTVAPPRVSTKICDLIGNTPALELCRTGTGSRLILKLDCFNPTGSVKIRMAMEMVQ
GAERAGLLRPGSRIVEPTSGNTGLGLAIAASQRGYRFTAVVDHHAAKDKLDAMRALGAELIFVGSPDTSKPSTVARRSMA
KHIVESDPNAWWPDQHNNPDNPGGYAQLAHELSAQCSDGVDVLVAAVGTGGTLCGTTRELRRMGHEAKTVGVEPEGSIIF
GGPAGSYKQSGAGAPGGFTIGQNVDYALIDQQIKVGDVKAFATSRVLARRHGLMVGGTAGAAVHEGLQTLQTCAANSTVV
VLVCDAGEKYLDTVFNDAWLDSHGLRSEIAERHVENMLRAYRDSRSLCAGCQAPRCSAVRR
>Mature_381_residues
MKISTRTTHSAMSGAGGESAHPAVCTVAPPRVSTKICDLIGNTPALELCRTGTGSRLILKLDCFNPTGSVKIRMAMEMVQ
GAERAGLLRPGSRIVEPTSGNTGLGLAIAASQRGYRFTAVVDHHAAKDKLDAMRALGAELIFVGSPDTSKPSTVARRSMA
KHIVESDPNAWWPDQHNNPDNPGGYAQLAHELSAQCSDGVDVLVAAVGTGGTLCGTTRELRRMGHEAKTVGVEPEGSIIF
GGPAGSYKQSGAGAPGGFTIGQNVDYALIDQQIKVGDVKAFATSRVLARRHGLMVGGTAGAAVHEGLQTLQTCAANSTVV
VLVCDAGEKYLDTVFNDAWLDSHGLRSEIAERHVENMLRAYRDSRSLCAGCQAPRCSAVRR

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=343, Percent_Identity=34.402332361516, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295821200, Length=343, Percent_Identity=34.402332361516, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4557415, Length=343, Percent_Identity=34.402332361516, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI11345492, Length=323, Percent_Identity=26.9349845201238, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=35.3135313531353, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=35.1097178683386, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=32.2368421052632, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=334, Percent_Identity=33.8323353293413, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17534315, Length=338, Percent_Identity=32.5443786982249, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=32.6860841423948, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=33.0097087378641, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI115535073, Length=326, Percent_Identity=30.6748466257669, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32566672, Length=204, Percent_Identity=30.3921568627451, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71996324, Length=331, Percent_Identity=26.8882175226586, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539640, Length=344, Percent_Identity=23.546511627907, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539800, Length=346, Percent_Identity=23.9884393063584, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=337, Percent_Identity=31.4540059347181, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321449, Length=353, Percent_Identity=26.3456090651558, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24643623, Length=333, Percent_Identity=32.1321321321321, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20129101, Length=333, Percent_Identity=32.1321321321321, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 40043; Mature: 40043

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISTRTTHSAMSGAGGESAHPAVCTVAPPRVSTKICDLIGNTPALELCRTGTGSRLILK
CCCCCCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEE
LDCFNPTGSVKIRMAMEMVQGAERAGLLRPGSRIVEPTSGNTGLGLAIAASQRGYRFTAV
EECCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEECCCCEEEEEE
VDHHAAKDKLDAMRALGAELIFVGSPDTSKPSTVARRSMAKHIVESDPNAWWPDQHNNPD
ECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NPGGYAQLAHELSAQCSDGVDVLVAAVGTGGTLCGTTRELRRMGHEAKTVGVEPEGSIIF
CCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCHHHEECCCCCCCEEE
GGPAGSYKQSGAGAPGGFTIGQNVDYALIDQQIKVGDVKAFATSRVLARRHGLMVGGTAG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCHHHHHHHHHHHHHCCEEEECCCH
AAVHEGLQTLQTCAANSTVVVLVCDAGEKYLDTVFNDAWLDSHGLRSEIAERHVENMLRA
HHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YRDSRSLCAGCQAPRCSAVRR
HHCCHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MKISTRTTHSAMSGAGGESAHPAVCTVAPPRVSTKICDLIGNTPALELCRTGTGSRLILK
CCCCCCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEEE
LDCFNPTGSVKIRMAMEMVQGAERAGLLRPGSRIVEPTSGNTGLGLAIAASQRGYRFTAV
EECCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEECCCCEEEEEE
VDHHAAKDKLDAMRALGAELIFVGSPDTSKPSTVARRSMAKHIVESDPNAWWPDQHNNPD
ECCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NPGGYAQLAHELSAQCSDGVDVLVAAVGTGGTLCGTTRELRRMGHEAKTVGVEPEGSIIF
CCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCHHHEECCCCCCCEEE
GGPAGSYKQSGAGAPGGFTIGQNVDYALIDQQIKVGDVKAFATSRVLARRHGLMVGGTAG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEECCHHHHHHHHHHHHHCCEEEECCCH
AAVHEGLQTLQTCAANSTVVVLVCDAGEKYLDTVFNDAWLDSHGLRSEIAERHVENMLRA
HHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YRDSRSLCAGCQAPRCSAVRR
HHCCHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]