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The map label for this gene is accBC2 [H]

Identifier: 68536759

GI number: 68536759

Start: 1946956

End: 1948749

Strand: Direct

Name: accBC2 [H]

Synonym: jk1669

Alternate gene names: 68536759

Gene position: 1946956-1948749 (Clockwise)

Preceding gene: 68536758

Following gene: 68536760

Centisome position: 79.06

GC content: 63.38

Gene sequence:

>1794_bases
GTGACTTCCAGCTCCGCCGCTGACTTGACGAAGGTACTGATCGCCAACCGTGGCGAGATTGCAGTGCGCGTCATCCGGGC
TGCGCGCGACGAGGGTATCGCTACCGTCGCCGTGTACGCCGATCCGGATGCCGAGGCGCCCTTCGTACGCATGGCAGACG
AAGCGCTGGCCCTTGGAGGTCAGACTTCGGCGGAAACTTACCTGGATATCGACAAGATCATCGCCGCTGCCGCTAAGTCC
GGCGCCGATGCGATCCACCCCGGTTATGGCTTCCTGTCGGAAAACGCAGACTTCGCCCAGGCCGTCGTCGATGCGGGCCT
GAACTGGATCGGTCCGCCGCCGGAGGCGATTCGCAAGCTCGGCGATAAGGTCACTGCCCGAAACATCGCTCTTAGTGTTG
ACGCCCCTATGACTCCGGGCACTAAGGAGCCTGTCGCGGATGCTGCAGAGGTCACCGCCTTTGCGGAGCGTCACGGACTT
CCAATCGCTATCAAGGCCGCCTTCGGCGGTGGTGGGCGTGGCATGAAGGTCGCCTACACCCTGGACGAGATTCCGGATCT
CTTTGAATCTGCGACCCGCGAAGCCATCACCGCCTTCGGCCGTGGCGAGTGCTTCGTGGAGCGCTACCTGGACCGCGCCC
GCCATGTCGAGGCGCAGGTCGTGGCTGATAAGCACGGCAATGTCGTTGTCGCCTCCACCCGCGACTGCTCCGCCCAGCGG
CGTTTTCAGAAGCTCATCGAGGAAGCACCTGCACCATTCTTGAGCGACGAGCAGAACGAGCGCATCTACTCCTCCGCCAA
GGCCATCTGCCGCGAGGCGGGCTACTACGGTGCGGGCACGGTGGAGTACCTGGTGGGCTCCGACGGGCTGATCAGCTTCC
TGGAAGTTAACACTCGCCTGCAGGTGGAGCACCCTGTCACCGAGCAGGTCACCGGCTGGGATCTGGTACGCGAGCAGTTC
CGTATTGCCCGTGGCGAGGAGCTATCCCGCACTGAGGATCCGGAGATTATCGGCCACTCCATCGAGTTCCGCATCAACGG
CGAAGATCCGGCGAACAACTTCATGCCCGCCCCGGGCCGCATTCAGACCTACCGCGAGCCCGCAGGCCCCGGCGTGCGCA
TGGACTCCGGCATCGAAACCGGCACGGTGATCGGCGGCCAGTTCGACTCCATGCTGGCCAAGCTCATCGTCACCGGCGCC
GACCGCGCCGAGGCTATTCAGCGTTCCCTGCGGGCACTGGAAGAGTACGAGGTCGAAGGCATCCCAACCGTTATCCCCTT
CCACCAGGCTGCGCTGAATGATCCGGCCTTCGTTGCCGAAGACGGAAACTACCGCGTGTACACCCGGTGGATCGAAGAGG
AGTGGGACAACCAGCTGCCCGCCTACGAGGAGCCGCTTGCAGCAGCTGCCGAGGGCCAGCTGCCAAAGGAAAAGCTGGTC
GTCGAGGTTGACGGCCGCCGCGTGGAGGTGCTGGTTCCGGGCGAAATTCTGGCGAGCCGTGGATCGGTGAGCCGTGCGAA
GAAGCGTCGCGCAAATGCTGCGGACATCGCCATCACCGGCGACACGGTGGCCGCCCCAATGCAGGGCACTGTGATCAAGG
TGGAAGTCGCGGAAGGCGACGAAGTGGCCGAGGGCGACGTTCTGCTGGTGCTCGAGGCGATGAAGATGGAAAACGCCGTC
AAGGCGCACAAGTCCGGTGTGGTGCAGTCCTTAAGCGTCGGAAGCGGCGATGGCGTCACAAAGAATCAAGCACTTATGGA
GCTGAAGAACGACAGCTCCGCCGAGAACGAATAG

Upstream 100 bases:

>100_bases
TCGAATGGGGAAACATGATGCGCGTGCCCATCGAGCGTGGCTAACTGGGGCGTGTAGCCTCATTAACTAACCCCTAACTA
ATAACCCGAAAGGATTGCCC

Downstream 100 bases:

>100_bases
ACGAGACAGGAAACACACCCCATGACTGAAACCCCTTCTGCGCAGGCAACCACGGTCGAAAAGAAGACGCCCAAGGGCAT
GACCTTCCTCGGACTAGGGC

Product: acyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MTSSSAADLTKVLIANRGEIAVRVIRAARDEGIATVAVYADPDAEAPFVRMADEALALGGQTSAETYLDIDKIIAAAAKS
GADAIHPGYGFLSENADFAQAVVDAGLNWIGPPPEAIRKLGDKVTARNIALSVDAPMTPGTKEPVADAAEVTAFAERHGL
PIAIKAAFGGGGRGMKVAYTLDEIPDLFESATREAITAFGRGECFVERYLDRARHVEAQVVADKHGNVVVASTRDCSAQR
RFQKLIEEAPAPFLSDEQNERIYSSAKAICREAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEQVTGWDLVREQF
RIARGEELSRTEDPEIIGHSIEFRINGEDPANNFMPAPGRIQTYREPAGPGVRMDSGIETGTVIGGQFDSMLAKLIVTGA
DRAEAIQRSLRALEEYEVEGIPTVIPFHQAALNDPAFVAEDGNYRVYTRWIEEEWDNQLPAYEEPLAAAAEGQLPKEKLV
VEVDGRRVEVLVPGEILASRGSVSRAKKRRANAADIAITGDTVAAPMQGTVIKVEVAEGDEVAEGDVLLVLEAMKMENAV
KAHKSGVVQSLSVGSGDGVTKNQALMELKNDSSAENE

Sequences:

>Translated_597_residues
MTSSSAADLTKVLIANRGEIAVRVIRAARDEGIATVAVYADPDAEAPFVRMADEALALGGQTSAETYLDIDKIIAAAAKS
GADAIHPGYGFLSENADFAQAVVDAGLNWIGPPPEAIRKLGDKVTARNIALSVDAPMTPGTKEPVADAAEVTAFAERHGL
PIAIKAAFGGGGRGMKVAYTLDEIPDLFESATREAITAFGRGECFVERYLDRARHVEAQVVADKHGNVVVASTRDCSAQR
RFQKLIEEAPAPFLSDEQNERIYSSAKAICREAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEQVTGWDLVREQF
RIARGEELSRTEDPEIIGHSIEFRINGEDPANNFMPAPGRIQTYREPAGPGVRMDSGIETGTVIGGQFDSMLAKLIVTGA
DRAEAIQRSLRALEEYEVEGIPTVIPFHQAALNDPAFVAEDGNYRVYTRWIEEEWDNQLPAYEEPLAAAAEGQLPKEKLV
VEVDGRRVEVLVPGEILASRGSVSRAKKRRANAADIAITGDTVAAPMQGTVIKVEVAEGDEVAEGDVLLVLEAMKMENAV
KAHKSGVVQSLSVGSGDGVTKNQALMELKNDSSAENE
>Mature_596_residues
TSSSAADLTKVLIANRGEIAVRVIRAARDEGIATVAVYADPDAEAPFVRMADEALALGGQTSAETYLDIDKIIAAAAKSG
ADAIHPGYGFLSENADFAQAVVDAGLNWIGPPPEAIRKLGDKVTARNIALSVDAPMTPGTKEPVADAAEVTAFAERHGLP
IAIKAAFGGGGRGMKVAYTLDEIPDLFESATREAITAFGRGECFVERYLDRARHVEAQVVADKHGNVVVASTRDCSAQRR
FQKLIEEAPAPFLSDEQNERIYSSAKAICREAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEQVTGWDLVREQFR
IARGEELSRTEDPEIIGHSIEFRINGEDPANNFMPAPGRIQTYREPAGPGVRMDSGIETGTVIGGQFDSMLAKLIVTGAD
RAEAIQRSLRALEEYEVEGIPTVIPFHQAALNDPAFVAEDGNYRVYTRWIEEEWDNQLPAYEEPLAAAAEGQLPKEKLVV
EVDGRRVEVLVPGEILASRGSVSRAKKRRANAADIAITGDTVAAPMQGTVIKVEVAEGDEVAEGDVLLVLEAMKMENAVK
AHKSGVVQSLSVGSGDGVTKNQALMELKNDSSAENE

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI295821183, Length=627, Percent_Identity=37.4800637958533, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI189095269, Length=664, Percent_Identity=36.144578313253, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI65506442, Length=664, Percent_Identity=36.144578313253, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI116805327, Length=487, Percent_Identity=42.7104722792608, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=44.7893569844789, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=44.7893569844789, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=44.7893569844789, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI134142062, Length=476, Percent_Identity=31.5126050420168, Blast_Score=212, Evalue=8e-55,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=30.511811023622, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=30.511811023622, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=30.511811023622, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=30.511811023622, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=30.511811023622, Blast_Score=210, Evalue=3e-54,
Organism=Escherichia coli, GI1789654, Length=431, Percent_Identity=45.9396751740139, Blast_Score=348, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=43.7086092715232, Blast_Score=357, Evalue=9e-99,
Organism=Caenorhabditis elegans, GI71987519, Length=460, Percent_Identity=43.4782608695652, Blast_Score=344, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=41.5178571428571, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI133931226, Length=549, Percent_Identity=27.6867030965392, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=28.1800391389432, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.1800391389432, Blast_Score=192, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=46.0176991150442, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=44.6902654867257, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=431, Percent_Identity=42.92343387471, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6323863, Length=443, Percent_Identity=30.9255079006772, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6324343, Length=561, Percent_Identity=29.4117647058824, Blast_Score=203, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24652212, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=434, Percent_Identity=45.852534562212, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651757, Length=456, Percent_Identity=41.0087719298246, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24651759, Length=415, Percent_Identity=39.5180722891566, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI161076409, Length=467, Percent_Identity=30.406852248394, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24586458, Length=467, Percent_Identity=30.406852248394, Blast_Score=202, Evalue=8e-52,
Organism=Drosophila melanogaster, GI161076407, Length=467, Percent_Identity=30.6209850107066, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24586460, Length=467, Percent_Identity=30.6209850107066, Blast_Score=201, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 64087; Mature: 63955

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSAADLTKVLIANRGEIAVRVIRAARDEGIATVAVYADPDAEAPFVRMADEALALGG
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
QTSAETYLDIDKIIAAAAKSGADAIHPGYGFLSENADFAQAVVDAGLNWIGPPPEAIRKL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
GDKVTARNIALSVDAPMTPGTKEPVADAAEVTAFAERHGLPIAIKAAFGGGGRGMKVAYT
CCHHEECEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEE
LDEIPDLFESATREAITAFGRGECFVERYLDRARHVEAQVVADKHGNVVVASTRDCSAQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCHHHH
RFQKLIEEAPAPFLSDEQNERIYSSAKAICREAGYYGAGTVEYLVGSDGLISFLEVNTRL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEQVTGWDLVREQFRIARGEELSRTEDPEIIGHSIEFRINGEDPANNFMPAPGR
EECCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
IQTYREPAGPGVRMDSGIETGTVIGGQFDSMLAKLIVTGADRAEAIQRSLRALEEYEVEG
CEECCCCCCCCCEECCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
IPTVIPFHQAALNDPAFVAEDGNYRVYTRWIEEEWDNQLPAYEEPLAAAAEGQLPKEKLV
CCEEECCHHHHCCCCCEEEECCCEEEEEEEHHHHHCCCCCCCCCCHHHHHCCCCCHHHEE
VEVDGRRVEVLVPGEILASRGSVSRAKKRRANAADIAITGDTVAAPMQGTVIKVEVAEGD
EEECCCEEEEEECHHHHHCCCCHHHHHHHCCCCCEEEEECCCEECCCCCCEEEEEECCCC
EVAEGDVLLVLEAMKMENAVKAHKSGVVQSLSVGSGDGVTKNQALMELKNDSSAENE
CCCCCCEEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TSSSAADLTKVLIANRGEIAVRVIRAARDEGIATVAVYADPDAEAPFVRMADEALALGG
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
QTSAETYLDIDKIIAAAAKSGADAIHPGYGFLSENADFAQAVVDAGLNWIGPPPEAIRKL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
GDKVTARNIALSVDAPMTPGTKEPVADAAEVTAFAERHGLPIAIKAAFGGGGRGMKVAYT
CCHHEECEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEE
LDEIPDLFESATREAITAFGRGECFVERYLDRARHVEAQVVADKHGNVVVASTRDCSAQR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCCHHHH
RFQKLIEEAPAPFLSDEQNERIYSSAKAICREAGYYGAGTVEYLVGSDGLISFLEVNTRL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEE
QVEHPVTEQVTGWDLVREQFRIARGEELSRTEDPEIIGHSIEFRINGEDPANNFMPAPGR
EECCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
IQTYREPAGPGVRMDSGIETGTVIGGQFDSMLAKLIVTGADRAEAIQRSLRALEEYEVEG
CEECCCCCCCCCEECCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
IPTVIPFHQAALNDPAFVAEDGNYRVYTRWIEEEWDNQLPAYEEPLAAAAEGQLPKEKLV
CCEEECCHHHHCCCCCEEEECCCEEEEEEEHHHHHCCCCCCCCCCHHHHHCCCCCHHHEE
VEVDGRRVEVLVPGEILASRGSVSRAKKRRANAADIAITGDTVAAPMQGTVIKVEVAEGD
EEECCCEEEEEECHHHHHCCCCHHHHHHHCCCCCEEEEECCCEECCCCCCEEEEEECCCC
EVAEGDVLLVLEAMKMENAVKAHKSGVVQSLSVGSGDGVTKNQALMELKNDSSAENE
CCCCCCEEEEEEHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]