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The map label for this gene is glmU [H]

Identifier: 68536578

GI number: 68536578

Start: 1758387

End: 1759904

Strand: Direct

Name: glmU [H]

Synonym: jk1492

Alternate gene names: 68536578

Gene position: 1758387-1759904 (Clockwise)

Preceding gene: 68536577

Following gene: 68536579

Centisome position: 71.41

GC content: 65.09

Gene sequence:

>1518_bases
GTGACTGATGCTGCTCAGAACCCCGAAGCTCACCTAAAGGCCCAAGACAAGCCTGTGGCAGTGATCGTGCTGGCCGCAGG
GGCGGGCACGCGGATGAAGTCCACGACCCAAAAGACCCTGCACTCCATTGGCGGGCGCACCCTCCTTTCCCACAGCCTGC
ACGCCGCCGCTGGCATCGACCCCGCCCGCATCGTGGCTGTTATCGGCCATGGGCGGGAGCAAGTAGGACCGGCAGTAGCA
GAGGTAGCCGAGCAACTGGGGCGCAGCATCGACACTGCAATCCAGGAGCAGCAGAACGGCACCGGCCACGCCGTACAGTG
CGCAATGGAACAGCTGGAGGGCTTCGAAGGCACCGTTGTGGTTACCAACGCGGACGTACCTCTACTTTCCCCGGAGACTC
TGCAGGAACTTACTGCCACCCACGACGGCGCGAGCGTGACCGTGCTGTCCGTCAACCAGGACAACCCCACCGGTTACGGC
CGCATCCTGCGTACCAACGATGGCATGGTCACCGCCATCGTGGAGGAAAAGGACGCAACGGAGAAGCAGAAGGAAATCAC
TGAGGTCAACTCCGGTGTGTTCGCCTTCGACGCGGCTATCCTGCGCGACGGCTTGGCGCAGTTGAACACTGATAACGCCC
AGGGCGAGCTATACCTGACGGACGTGCTGAGCATCGCCCGCCGGGCGGGCCACCCCGTGCGCGCCCACATCGCCTCCGAC
GCTGCGGAACTAGCGGGCGTCAACGACCGCGTCCAGCTAGCCGCCGCCGGCGCCGAGCTCAACCGCCGCACCGTGACCGC
CGCGATGCGAGGCGGGGCGACCATCGTAGATCCGGCGACAACTTGGATCGACGTGGATGTGCAGGTAGGCCAGGACGTCA
CTATCCTGCCGGGAACGCAGCTGCTAGGCACCACCACCATCGGTGATAACGCGCAGATCGGACCGGATACCACTCTAGAA
AACGTCAAGGTCGGCGAAGGCGCGCAGGTAGTCCGCACCCACGGCTTTGATTCCACCATCGGCCCGCGCGCCGAAGTAGG
CCCCTTTACCTACATCCGCCCCGGCACGGTGCTGGGCGAAGAGGGCAAGCTCGGCGGCTTCGTCGAGGCGAAGAAGGCGA
ACATCGGGCGAGGCTCGAAGGTGCCCCACCTGACCTATGTCGGCGACGCGACGATCGGCGAATACTCCAACATCGGCGCC
TCCAGCGTGTTCGTGAACTACGACGGTGTGAACAAGCACCACACCACCGTGGGCTCGCACGTGCGCACCGGATCCGATTC
AATGTTCATCGCCCCGGTCGTGGTGGGCGATGGCGCCTACTCCGGAGCCGGTACCGTCATCAAGGAAGACGTGCCACCGG
GCGCGCTGGTGGTCTCTGGTGGCAAGCAGCGCAACGTGGAGGGCTGGGTGGCTAAGAAGCGCCCCGGCACCCCAGCGGCA
GAGGCCGGCGAGGCCGCAGCCAAGCGTGTGGCGGAAGGCGGTTCGCCTACGTCAACACCACAGGCAGACCAGGAGTAG

Upstream 100 bases:

>100_bases
GAGATTTCTTAAGCGCTCGCGGGCGACCCTCCCCGACTCGGCGGCGAAGCGACGCTATGCTGGAATTCGCTTTTAACCGA
AAGTAAGGAATGCCAACAAC

Downstream 100 bases:

>100_bases
CAGACAGAAGCTACGCTCGTTTTTGTTGATATCTCTGAGCGCGACCTAAAATGGGGAGCGCCTGAATAAAAGTGAATAGT
CCAGCTCTTCGACCGGAAGG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTDAAQNPEAHLKAQDKPVAVIVLAAGAGTRMKSTTQKTLHSIGGRTLLSHSLHAAAGIDPARIVAVIGHGREQVGPAVA
EVAEQLGRSIDTAIQEQQNGTGHAVQCAMEQLEGFEGTVVVTNADVPLLSPETLQELTATHDGASVTVLSVNQDNPTGYG
RILRTNDGMVTAIVEEKDATEKQKEITEVNSGVFAFDAAILRDGLAQLNTDNAQGELYLTDVLSIARRAGHPVRAHIASD
AAELAGVNDRVQLAAAGAELNRRTVTAAMRGGATIVDPATTWIDVDVQVGQDVTILPGTQLLGTTTIGDNAQIGPDTTLE
NVKVGEGAQVVRTHGFDSTIGPRAEVGPFTYIRPGTVLGEEGKLGGFVEAKKANIGRGSKVPHLTYVGDATIGEYSNIGA
SSVFVNYDGVNKHHTTVGSHVRTGSDSMFIAPVVVGDGAYSGAGTVIKEDVPPGALVVSGGKQRNVEGWVAKKRPGTPAA
EAGEAAAKRVAEGGSPTSTPQADQE

Sequences:

>Translated_505_residues
MTDAAQNPEAHLKAQDKPVAVIVLAAGAGTRMKSTTQKTLHSIGGRTLLSHSLHAAAGIDPARIVAVIGHGREQVGPAVA
EVAEQLGRSIDTAIQEQQNGTGHAVQCAMEQLEGFEGTVVVTNADVPLLSPETLQELTATHDGASVTVLSVNQDNPTGYG
RILRTNDGMVTAIVEEKDATEKQKEITEVNSGVFAFDAAILRDGLAQLNTDNAQGELYLTDVLSIARRAGHPVRAHIASD
AAELAGVNDRVQLAAAGAELNRRTVTAAMRGGATIVDPATTWIDVDVQVGQDVTILPGTQLLGTTTIGDNAQIGPDTTLE
NVKVGEGAQVVRTHGFDSTIGPRAEVGPFTYIRPGTVLGEEGKLGGFVEAKKANIGRGSKVPHLTYVGDATIGEYSNIGA
SSVFVNYDGVNKHHTTVGSHVRTGSDSMFIAPVVVGDGAYSGAGTVIKEDVPPGALVVSGGKQRNVEGWVAKKRPGTPAA
EAGEAAAKRVAEGGSPTSTPQADQE
>Mature_504_residues
TDAAQNPEAHLKAQDKPVAVIVLAAGAGTRMKSTTQKTLHSIGGRTLLSHSLHAAAGIDPARIVAVIGHGREQVGPAVAE
VAEQLGRSIDTAIQEQQNGTGHAVQCAMEQLEGFEGTVVVTNADVPLLSPETLQELTATHDGASVTVLSVNQDNPTGYGR
ILRTNDGMVTAIVEEKDATEKQKEITEVNSGVFAFDAAILRDGLAQLNTDNAQGELYLTDVLSIARRAGHPVRAHIASDA
AELAGVNDRVQLAAAGAELNRRTVTAAMRGGATIVDPATTWIDVDVQVGQDVTILPGTQLLGTTTIGDNAQIGPDTTLEN
VKVGEGAQVVRTHGFDSTIGPRAEVGPFTYIRPGTVLGEEGKLGGFVEAKKANIGRGSKVPHLTYVGDATIGEYSNIGAS
SVFVNYDGVNKHHTTVGSHVRTGSDSMFIAPVVVGDGAYSGAGTVIKEDVPPGALVVSGGKQRNVEGWVAKKRPGTPAAE
AGEAAAKRVAEGGSPTSTPQADQE

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=37.527114967462, Blast_Score=293, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21355443, Length=384, Percent_Identity=23.6979166666667, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644084, Length=384, Percent_Identity=23.6979166666667, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 52227; Mature: 52096

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAAQNPEAHLKAQDKPVAVIVLAAGAGTRMKSTTQKTLHSIGGRTLLSHSLHAAAGID
CCCCCCCCHHHEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PARIVAVIGHGREQVGPAVAEVAEQLGRSIDTAIQEQQNGTGHAVQCAMEQLEGFEGTVV
HHHEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
VTNADVPLLSPETLQELTATHDGASVTVLSVNQDNPTGYGRILRTNDGMVTAIVEEKDAT
EEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCH
EKQKEITEVNSGVFAFDAAILRDGLAQLNTDNAQGELYLTDVLSIARRAGHPVRAHIASD
HHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCCEEEHHHHH
AAELAGVNDRVQLAAAGAELNRRTVTAAMRGGATIVDPATTWIDVDVQVGQDVTILPGTQ
HHHHCCCCCCEEEEECCCCCCCCEEEEHHCCCCEEECCCCEEEEEEEECCCCEEEECCCC
LLGTTTIGDNAQIGPDTTLENVKVGEGAQVVRTHGFDSTIGPRAEVGPFTYIRPGTVLGE
EEEEEECCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEECC
EGKLGGFVEAKKANIGRGSKVPHLTYVGDATIGEYSNIGASSVFVNYDGVNKHHTTVGSH
CCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCE
VRTGSDSMFIAPVVVGDGAYSGAGTVIKEDVPPGALVVSGGKQRNVEGWVAKKRPGTPAA
EECCCCCEEEEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCEEECCCCCCCCH
EAGEAAAKRVAEGGSPTSTPQADQE
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDAAQNPEAHLKAQDKPVAVIVLAAGAGTRMKSTTQKTLHSIGGRTLLSHSLHAAAGID
CCCCCCCHHHEEECCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PARIVAVIGHGREQVGPAVAEVAEQLGRSIDTAIQEQQNGTGHAVQCAMEQLEGFEGTVV
HHHEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEE
VTNADVPLLSPETLQELTATHDGASVTVLSVNQDNPTGYGRILRTNDGMVTAIVEEKDAT
EEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCH
EKQKEITEVNSGVFAFDAAILRDGLAQLNTDNAQGELYLTDVLSIARRAGHPVRAHIASD
HHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCCCEEEHHHHH
AAELAGVNDRVQLAAAGAELNRRTVTAAMRGGATIVDPATTWIDVDVQVGQDVTILPGTQ
HHHHCCCCCCEEEEECCCCCCCCEEEEHHCCCCEEECCCCEEEEEEEECCCCEEEECCCC
LLGTTTIGDNAQIGPDTTLENVKVGEGAQVVRTHGFDSTIGPRAEVGPFTYIRPGTVLGE
EEEEEECCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCEECC
EGKLGGFVEAKKANIGRGSKVPHLTYVGDATIGEYSNIGASSVFVNYDGVNKHHTTVGSH
CCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCE
VRTGSDSMFIAPVVVGDGAYSGAGTVIKEDVPPGALVVSGGKQRNVEGWVAKKRPGTPAA
EECCCCCEEEEEEEECCCCCCCCCCEEECCCCCCEEEECCCCCCCCCCEEECCCCCCCCH
EAGEAAAKRVAEGGSPTSTPQADQE
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA