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The map label for this gene is dtxR

Identifier: 68536174

GI number: 68536174

Start: 1288985

End: 1289707

Strand: Direct

Name: dtxR

Synonym: jk1097

Alternate gene names: 68536174

Gene position: 1288985-1289707 (Clockwise)

Preceding gene: 68536171

Following gene: 68536175

Centisome position: 52.34

GC content: 58.09

Gene sequence:

>723_bases
GTGAGGGATCTCGTCGATACTACTGAGATGTATCTCCGAACGATTTACGAGTTGGAAGAAGAAGGCATCCCACCGCTGCG
CGCCCGCATCGCCGAAAGACTTGATCAGTCCGGCCCCACCGTGAGCCAGACTGTCGCCCGCATGGAACGCGACGAGCTTC
TGACCGTTGAAAAGGATCGTTCCTTGAAGCTCAGCGCACAGGGGCGCGCCCTGGCCACTGCCGTAATGCGTAAACACCGC
CTGGCGGAGCGCCTGCTTACCGACGTAATCGGCCTTCCTTGGGAAAAGGTGCACGATGAAGCCTGCCGCTGGGAACACGT
CATGGGCGACGAAGTTGAGGTTCAGCTGGTAAAGGTGCTCAGTGAGTACGCCACCTCTCCCTTTGGAAACCCAATCCCGG
GTCTGGACGAGCTGATGGAGGGCATCCCGGATTCCGAGCGAGCTGAGCTGCAGCAAAAGATTGACAACCTGCAGGTGGTT
ACCTCGCAACGCGCATCCGACATCGAACCACCGGAGCCGATCCAGGTGAAGATCCTGAGCATCAACGAAATCATCCAGGT
CGAGCACAAGCTAATGGCTAAATTCCACGCGCTCGGAATGCGTCCGGGAAGTGTTGTAGATCTCGTGGCCACCGAGGACG
GCCTGGAGTTCAGTAACGACAACGGCGCCATGGTGGTTCCAGAAGAACTCGGCCACGCCGTGCGGGTAGAGAAAGTCAAC
TAA

Upstream 100 bases:

>100_bases
TCTGCGGTTATGCTGGGATGCGGACACACTTTTTGTCTATTAACCCTGAACGGGGCTATAATCGTGTGAAGTCAATAAGC
AAAGAAAGGGCGTAGCGCAC

Downstream 100 bases:

>100_bases
TTGGTGCGGTAGCGTGGGGAATGTGAGTAGCATCGATCTTTCCTCTTCCTCCCTGTCCCCCTCATCCCACATTGTCGTCA
CCGGTGGCGCCGGATACGTA

Product: iron-dependent repressor DtxR

Products: NA

Alternate protein names: Iron-dependent diphtheria tox regulatory element; Tox regulatory factor

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRDLVDTTEMYLRTIYELEEEGIPPLRARIAERLDQSGPTVSQTVARMERDELLTVEKDRSLKLSAQGRALATAVMRKHR
LAERLLTDVIGLPWEKVHDEACRWEHVMGDEVEVQLVKVLSEYATSPFGNPIPGLDELMEGIPDSERAELQQKIDNLQVV
TSQRASDIEPPEPIQVKILSINEIIQVEHKLMAKFHALGMRPGSVVDLVATEDGLEFSNDNGAMVVPEELGHAVRVEKVN

Sequences:

>Translated_240_residues
MRDLVDTTEMYLRTIYELEEEGIPPLRARIAERLDQSGPTVSQTVARMERDELLTVEKDRSLKLSAQGRALATAVMRKHR
LAERLLTDVIGLPWEKVHDEACRWEHVMGDEVEVQLVKVLSEYATSPFGNPIPGLDELMEGIPDSERAELQQKIDNLQVV
TSQRASDIEPPEPIQVKILSINEIIQVEHKLMAKFHALGMRPGSVVDLVATEDGLEFSNDNGAMVVPEELGHAVRVEKVN
>Mature_240_residues
MRDLVDTTEMYLRTIYELEEEGIPPLRARIAERLDQSGPTVSQTVARMERDELLTVEKDRSLKLSAQGRALATAVMRKHR
LAERLLTDVIGLPWEKVHDEACRWEHVMGDEVEVQLVKVLSEYATSPFGNPIPGLDELMEGIPDSERAELQQKIDNLQVV
TSQRASDIEPPEPIQVKILSINEIIQVEHKLMAKFHALGMRPGSVVDLVATEDGLEFSNDNGAMVVPEELGHAVRVEKVN

Specific function: Iron-binding repressor of the dipheteria toxin gene expression. May serve as a global regulator of gene expression

COG id: COG1321

COG function: function code K; Mn-dependent transcriptional regulator

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH dtxR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTXR_CORJK (Q4JV96)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250879.1
- ProteinModelPortal:   Q4JV96
- SMR:   Q4JV96
- STRING:   Q4JV96
- GeneID:   3433720
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk1097
- NMPDR:   fig|306537.3.peg.1020
- eggNOG:   COG1321
- HOGENOM:   HBG731603
- OMA:   TDVIGLP
- ProtClustDB:   CLSK2309299
- BioCyc:   CJEI306537:JK1097-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001367
- InterPro:   IPR022689
- InterPro:   IPR022687
- InterPro:   IPR008988
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.60.10
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00529

Pfam domain/function: PF02742 Fe_dep_repr_C; PF01325 Fe_dep_repress; SSF47979 HTH_DtxR; SSF50037 Transcr_rep_C

EC number: NA

Molecular weight: Translated: 26964; Mature: 26964

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50944 HTH_DTXR; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLVDTTEMYLRTIYELEEEGIPPLRARIAERLDQSGPTVSQTVARMERDELLTVEKDR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCC
SLKLSAQGRALATAVMRKHRLAERLLTDVIGLPWEKVHDEACRWEHVMGDEVEVQLVKVL
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
SEYATSPFGNPIPGLDELMEGIPDSERAELQQKIDNLQVVTSQRASDIEPPEPIQVKILS
HHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
INEIIQVEHKLMAKFHALGMRPGSVVDLVATEDGLEFSNDNGAMVVPEELGHAVRVEKVN
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEEEHHHCCCEEEEEECC
>Mature Secondary Structure
MRDLVDTTEMYLRTIYELEEEGIPPLRARIAERLDQSGPTVSQTVARMERDELLTVEKDR
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCC
SLKLSAQGRALATAVMRKHRLAERLLTDVIGLPWEKVHDEACRWEHVMGDEVEVQLVKVL
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
SEYATSPFGNPIPGLDELMEGIPDSERAELQQKIDNLQVVTSQRASDIEPPEPIQVKILS
HHHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
INEIIQVEHKLMAKFHALGMRPGSVVDLVATEDGLEFSNDNGAMVVPEELGHAVRVEKVN
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEECCCCCEEEHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA