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The map label for this gene is ppiB [H]

Identifier: 68536124

GI number: 68536124

Start: 1238259

End: 1239122

Strand: Direct

Name: ppiB [H]

Synonym: jk1047

Alternate gene names: 68536124

Gene position: 1238259-1239122 (Clockwise)

Preceding gene: 68536119

Following gene: 68536148

Centisome position: 50.28

GC content: 61.11

Gene sequence:

>864_bases
GTGTCAGACAACAACTACCCGAACGAGGCCCAGCGCGACCAGGCACTGTCGGAGCTAGAGAAAGCTCTGAAGTCCCGCGA
GCGCAAGGCCAAGATCGCACCGCTGGGCGTGGTAGCCGCAACACTCGCCGTGCTGGTGCTCATCGTGGGCGGCATCTGGT
TCGCCGCCACCTACACCTCCAACGAGGATGAAGATCAAGTCGCTGAGAGCGAGCAGCAGACTGAAGAGCCGGACGTAAAG
CCCGCGGCGCTACCGGCAGGCCCTAAGGAGCCTTACGGCGAGACCGTGAAGTGCGAGTACAAGAAGGACCCGCAGGGCAA
GCTCAGCGAGGCCGGGCTGCCTGACGGCAACAACGTAACCGCCAAGGGAACCGAAAAGGTCACCTTGACCATGAACGGCC
AAAAGGTTGGCTTGGAGCTGGCCAACGACAAGTCCCCGTGCTCCACCAATTCCTTCAAGCACCTGGTGGAGAAGAAGTTC
TACGACTCCACCAAGTGCCACCGCTCTGTGAAGTCCGATTCCATGACCATCCTGCAGTGCGGCGACCCTGAGGGTACTGG
CGCAGGCGGCCCGGGCTACTCCTTCGCAGATGAGTACCCGTCCAACGGCGTGGACAAGGACAAGGCCGACTCCCCGGTCA
CTTACAAGCGCGGCACACTAGCCATGGCCAACAGCGGACCGGATACCAACGGCAGCCAGTTCTTCCTGGTCACCGGTGAT
ACCACCCTGCCGCCGAGCTACAACATCTTCGGCACCATCGACGAGGCCGGCCTGAAGGCACTGGACAAGCTGATGGAAAA
GGCACCTGAAGGTGATGCGGCCCCGAATGAGGACATCAACATCGAATCCGCAGTACTGGGTTAG

Upstream 100 bases:

>100_bases
AGCGAAAACACCAACGAGCCCGTGCCCCTTCACCCGAATCGGCCAGTATATAGGGCATAATGGATCACCGTATCTAGCAC
AAGAAAGGTCCTAGAAAAAC

Downstream 100 bases:

>100_bases
ACAACTCGGCTAGCCTTCAGGGCTAGCCGCCCGTCGTGACACGGTAGACGTCGTAGACACCTTCGACGTTACGCAGCTGG
TTCATCATGTAGCCCAGCTG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSDNNYPNEAQRDQALSELEKALKSRERKAKIAPLGVVAATLAVLVLIVGGIWFAATYTSNEDEDQVAESEQQTEEPDVK
PAALPAGPKEPYGETVKCEYKKDPQGKLSEAGLPDGNNVTAKGTEKVTLTMNGQKVGLELANDKSPCSTNSFKHLVEKKF
YDSTKCHRSVKSDSMTILQCGDPEGTGAGGPGYSFADEYPSNGVDKDKADSPVTYKRGTLAMANSGPDTNGSQFFLVTGD
TTLPPSYNIFGTIDEAGLKALDKLMEKAPEGDAAPNEDINIESAVLG

Sequences:

>Translated_287_residues
MSDNNYPNEAQRDQALSELEKALKSRERKAKIAPLGVVAATLAVLVLIVGGIWFAATYTSNEDEDQVAESEQQTEEPDVK
PAALPAGPKEPYGETVKCEYKKDPQGKLSEAGLPDGNNVTAKGTEKVTLTMNGQKVGLELANDKSPCSTNSFKHLVEKKF
YDSTKCHRSVKSDSMTILQCGDPEGTGAGGPGYSFADEYPSNGVDKDKADSPVTYKRGTLAMANSGPDTNGSQFFLVTGD
TTLPPSYNIFGTIDEAGLKALDKLMEKAPEGDAAPNEDINIESAVLG
>Mature_286_residues
SDNNYPNEAQRDQALSELEKALKSRERKAKIAPLGVVAATLAVLVLIVGGIWFAATYTSNEDEDQVAESEQQTEEPDVKP
AALPAGPKEPYGETVKCEYKKDPQGKLSEAGLPDGNNVTAKGTEKVTLTMNGQKVGLELANDKSPCSTNSFKHLVEKKFY
DSTKCHRSVKSDSMTILQCGDPEGTGAGGPGYSFADEYPSNGVDKDKADSPVTYKRGTLAMANSGPDTNGSQFFLVTGDT
TLPPSYNIFGTIDEAGLKALDKLMEKAPEGDAAPNEDINIESAVLG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=33.7349397590361, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI7706339, Length=148, Percent_Identity=36.4864864864865, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI64276486, Length=163, Percent_Identity=32.5153374233129, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI20911035, Length=156, Percent_Identity=31.4102564102564, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=156, Percent_Identity=35.2564102564103, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=168, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32563659, Length=151, Percent_Identity=32.4503311258278, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=185, Percent_Identity=32.972972972973, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922376, Length=183, Percent_Identity=34.9726775956284, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=34.8387096774194, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 30574; Mature: 30443

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNNYPNEAQRDQALSELEKALKSRERKAKIAPLGVVAATLAVLVLIVGGIWFAATYTS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECC
NEDEDQVAESEQQTEEPDVKPAALPAGPKEPYGETVKCEYKKDPQGKLSEAGLPDGNNVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCEE
AKGTEKVTLTMNGQKVGLELANDKSPCSTNSFKHLVEKKFYDSTKCHRSVKSDSMTILQC
ECCCEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEC
GDPEGTGAGGPGYSFADEYPSNGVDKDKADSPVTYKRGTLAMANSGPDTNGSQFFLVTGD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCEEEEEECC
TTLPPSYNIFGTIDEAGLKALDKLMEKAPEGDAAPNEDINIESAVLG
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
SDNNYPNEAQRDQALSELEKALKSRERKAKIAPLGVVAATLAVLVLIVGGIWFAATYTS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECC
NEDEDQVAESEQQTEEPDVKPAALPAGPKEPYGETVKCEYKKDPQGKLSEAGLPDGNNVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCEE
AKGTEKVTLTMNGQKVGLELANDKSPCSTNSFKHLVEKKFYDSTKCHRSVKSDSMTILQC
ECCCEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEC
GDPEGTGAGGPGYSFADEYPSNGVDKDKADSPVTYKRGTLAMANSGPDTNGSQFFLVTGD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCCCCCCCCEEEEEECC
TTLPPSYNIFGTIDEAGLKALDKLMEKAPEGDAAPNEDINIESAVLG
CCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]