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The map label for this gene is ndk

Identifier: 68535626

GI number: 68535626

Start: 672768

End: 673178

Strand: Direct

Name: ndk

Synonym: jk0554

Alternate gene names: 68535626

Gene position: 672768-673178 (Clockwise)

Preceding gene: 68535625

Following gene: 68535628

Centisome position: 27.32

GC content: 63.02

Gene sequence:

>411_bases
ATGACTGAACGCACTCTGATTCTGATCAAGCCCGACGGTGTTAAGAACGGCCACGTGGGCGAAATTATCTCCCGCATCGA
AAAGAAGGGTCTGAAGCTCGTGGAGCTGGACCTGCGTACCGCTGACCGCGAGACCGCGGAGAAGCACTACGCTGAGCACT
CCGACAAGCCTTTCTTCGGCGAGCTGGTGGACTTCATCACCTCCGCTCCGCTGGTTGCCGGCATCGTTGAGGGCGAGTCC
GCTATCGCCGCTTGGCGCCAGCTGGCTGGTGGCACCCACCCGGTGGAGAAGGCCACCCCGGGCACCATCCGCGGCGACTT
CGCCCTGACCGTTGGCGAGAACGTTGTCCACGGCTCCGACTCCCCGGAGTCCGCTGAGCGCGAGATCGGCATCTGGTTCC
CGAACCTGTAA

Upstream 100 bases:

>100_bases
TGACCGCGCGTATGCGCTGATGGATCAGGTGCGCAGCCGCGTGTAGCGCCAAGGCGTTGCGGCGCTGTAGTGCCGTGACG
CCACGTGTAGAATTACTGGC

Downstream 100 bases:

>100_bases
ACAGCTGGAAAAATAAACCGCGGGCGCAGCGCGTCCGCGGTTTTTGTGCATCGGAGAGCTTCGGGCTAGCCGGCGTGCCG
CTCCTGGAAGTCTTGGGAGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 136; Mature: 135

Protein sequence:

>136_residues
MTERTLILIKPDGVKNGHVGEIISRIEKKGLKLVELDLRTADRETAEKHYAEHSDKPFFGELVDFITSAPLVAGIVEGES
AIAAWRQLAGGTHPVEKATPGTIRGDFALTVGENVVHGSDSPESAEREIGIWFPNL

Sequences:

>Translated_136_residues
MTERTLILIKPDGVKNGHVGEIISRIEKKGLKLVELDLRTADRETAEKHYAEHSDKPFFGELVDFITSAPLVAGIVEGES
AIAAWRQLAGGTHPVEKATPGTIRGDFALTVGENVVHGSDSPESAEREIGIWFPNL
>Mature_135_residues
TERTLILIKPDGVKNGHVGEIISRIEKKGLKLVELDLRTADRETAEKHYAEHSDKPFFGELVDFITSAPLVAGIVEGESA
IAAWRQLAGGTHPVEKATPGTIRGDFALTVGENVVHGSDSPESAEREIGIWFPNL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=132, Percent_Identity=50.7575757575758, Blast_Score=140, Evalue=3e-34,
Organism=Homo sapiens, GI4557797, Length=132, Percent_Identity=50.7575757575758, Blast_Score=140, Evalue=4e-34,
Organism=Homo sapiens, GI37693993, Length=131, Percent_Identity=51.1450381679389, Blast_Score=140, Evalue=4e-34,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=49.618320610687, Blast_Score=136, Evalue=5e-33,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=49.618320610687, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=49.618320610687, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=49.618320610687, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=49.618320610687, Blast_Score=136, Evalue=6e-33,
Organism=Homo sapiens, GI4826862, Length=131, Percent_Identity=43.5114503816794, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=36.2962962962963, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=36.2962962962963, Blast_Score=88, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=31.1594202898551, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=33.0882352941176, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=131, Percent_Identity=45.8015267175573, Blast_Score=115, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=132, Percent_Identity=49.2424242424242, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322783, Length=132, Percent_Identity=53.7878787878788, Blast_Score=146, Evalue=8e-37,
Organism=Drosophila melanogaster, GI45549037, Length=131, Percent_Identity=51.9083969465649, Blast_Score=146, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=34.5588235294118, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CORJK (Q4JWU4)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250331.1
- ProteinModelPortal:   Q4JWU4
- SMR:   Q4JWU4
- STRING:   Q4JWU4
- GeneID:   3432789
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0554
- NMPDR:   fig|306537.3.peg.550
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   CJEI306537:JK0554-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14770; Mature: 14639

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTLILIKPDGVKNGHVGEIISRIEKKGLKLVELDLRTADRETAEKHYAEHSDKPFFG
CCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHH
ELVDFITSAPLVAGIVEGESAIAAWRQLAGGTHPVEKATPGTIRGDFALTVGENVVHGSD
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEECCCC
SPESAEREIGIWFPNL
CCCCCCCEEEEECCCC
>Mature Secondary Structure 
TERTLILIKPDGVKNGHVGEIISRIEKKGLKLVELDLRTADRETAEKHYAEHSDKPFFG
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHH
ELVDFITSAPLVAGIVEGESAIAAWRQLAGGTHPVEKATPGTIRGDFALTVGENVVHGSD
HHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCEEECCCC
SPESAEREIGIWFPNL
CCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA