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The map label for this gene is purM [H]

Identifier: 68535424

GI number: 68535424

Start: 431331

End: 432425

Strand: Direct

Name: purM [H]

Synonym: jk0359

Alternate gene names: 68535424

Gene position: 431331-432425 (Clockwise)

Preceding gene: 68535423

Following gene: 68535426

Centisome position: 17.52

GC content: 65.57

Gene sequence:

>1095_bases
ATGAGTGAGCAACCAGAGAACACCCCTGCACAGGCGGCAGGTGCGTCCTACGCCGCCGCAGGTGTGGATATTGAGGCCGG
CGATCGTGCGGTAGAGCTCTTTGCTCCGCTGGCGAAGAAGGCCACCCGCCCTGAGGTCCGCGGCGGCCTTGGCGGATTTG
CCGGACTGTTCGCCCTGGGGAATTACGAAAAGCCTTTGCTGGCTGCATCCTCCGACGGCGTGGGCACCAAGCTGGCCGTC
GCCCAGGCGATGGACAAGCACGACACGATCGGCCGCGACTTGGTGGCTATGTGCGTGGACGACCTGGTTGTGTGCGGTGC
CGAGCCACTGTTCCTGCAGGATTACATCGCCATCGGCAAGGTAGTCCCCGAGCACGTCGCCAGTATCGTTTCGGGCATCG
CGGCGGGCTGCGAGGAAGCCGGCTGCGCCCTGCTGGGTGGCGAGACCGCCGAGCACCCGGGCGTGATGGAGCCTAATGAG
TACGACGTCTCCGCCACCTCCGTCGGCGTGGTCGAAGAGGCCAACCTGCTGGGACCGGACCGTGTGCGTCCGGGCGACGT
GGTGATCGCCATGGCCTCGTCCGGCCTGCACTCCAACGGCTACTCTCTGGCGCGCCACGTGCTTCTGGATACCAAGAAGC
TGCCGCTGGACGGTCACATCGACTCCCTCGGTCGCACCCTGGGGGAGGAGCTGCTGGAGCCCACCCGCATCTACGCCCTC
GACTGCCTGAAGTTGGCCAGCGAGTGCGATGTGCATACCTTCGCCCACATCACGGGCGGCGGCCTGGCAGCTAACCTGGC
CCGCGTGATTCCTGAGGGCCTGGTCGCGGAATTGGAGCGTTCCTCCTGGACCCCGGGCCCGATCTTCCGACTGATTCAGG
AGGAAGGCCAGGTTTCGCAGGAGGAGATGGAAAAGACCTTCAACATGGGCGTGGGCATGGTCGCCGTCGTCGCTGAAGAC
GATGCCGAACGTGCCATGGCTATGCTGACCGCTCGCCACATCGACGCATGGCGACTGGGCGAGGTACGCCCGGCAGAAGA
TGGCAAGTCCGGCGCGGTTCTTTCCGGCGAGTACCGCACCCCGGTGCAGGGCTAA

Upstream 100 bases:

>100_bases
TCGATGGCGTGTTCCCCCTAGGCATGCCGAGCGACAACCCGAATTCAGCGCTGGTCGAAACAATGCTGAAGCAACAGGCT
AAGAAAGCGAGTACTAAGCC

Downstream 100 bases:

>100_bases
AAGCTAACTGCGCGGGTTGCCCTGGTACAGGGCCGGGGCAGGGCAGGGTTAAGGGTCAAAATGTGTGTCTGGCTCGGCGT
GTCGCGGGGGTTAGATTTGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSEQPENTPAQAAGASYAAAGVDIEAGDRAVELFAPLAKKATRPEVRGGLGGFAGLFALGNYEKPLLAASSDGVGTKLAV
AQAMDKHDTIGRDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVASIVSGIAAGCEEAGCALLGGETAEHPGVMEPNE
YDVSATSVGVVEEANLLGPDRVRPGDVVIAMASSGLHSNGYSLARHVLLDTKKLPLDGHIDSLGRTLGEELLEPTRIYAL
DCLKLASECDVHTFAHITGGGLAANLARVIPEGLVAELERSSWTPGPIFRLIQEEGQVSQEEMEKTFNMGVGMVAVVAED
DAERAMAMLTARHIDAWRLGEVRPAEDGKSGAVLSGEYRTPVQG

Sequences:

>Translated_364_residues
MSEQPENTPAQAAGASYAAAGVDIEAGDRAVELFAPLAKKATRPEVRGGLGGFAGLFALGNYEKPLLAASSDGVGTKLAV
AQAMDKHDTIGRDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVASIVSGIAAGCEEAGCALLGGETAEHPGVMEPNE
YDVSATSVGVVEEANLLGPDRVRPGDVVIAMASSGLHSNGYSLARHVLLDTKKLPLDGHIDSLGRTLGEELLEPTRIYAL
DCLKLASECDVHTFAHITGGGLAANLARVIPEGLVAELERSSWTPGPIFRLIQEEGQVSQEEMEKTFNMGVGMVAVVAED
DAERAMAMLTARHIDAWRLGEVRPAEDGKSGAVLSGEYRTPVQG
>Mature_363_residues
SEQPENTPAQAAGASYAAAGVDIEAGDRAVELFAPLAKKATRPEVRGGLGGFAGLFALGNYEKPLLAASSDGVGTKLAVA
QAMDKHDTIGRDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVASIVSGIAAGCEEAGCALLGGETAEHPGVMEPNEY
DVSATSVGVVEEANLLGPDRVRPGDVVIAMASSGLHSNGYSLARHVLLDTKKLPLDGHIDSLGRTLGEELLEPTRIYALD
CLKLASECDVHTFAHITGGGLAANLARVIPEGLVAELERSSWTPGPIFRLIQEEGQVSQEEMEKTFNMGVGMVAVVAEDD
AERAMAMLTARHIDAWRLGEVRPAEDGKSGAVLSGEYRTPVQG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=45.906432748538, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=45.906432748538, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=45.906432748538, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788845, Length=332, Percent_Identity=46.9879518072289, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17567511, Length=353, Percent_Identity=35.1274787535411, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=39.3258426966292, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24582400, Length=302, Percent_Identity=36.7549668874172, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38079; Mature: 37947

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQPENTPAQAAGASYAAAGVDIEAGDRAVELFAPLAKKATRPEVRGGLGGFAGLFALG
CCCCCCCCCHHHCCCCHHHCCCEECCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCC
NYEKPLLAASSDGVGTKLAVAQAMDKHDTIGRDLVAMCVDDLVVCGAEPLFLQDYIAIGK
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVPEHVASIVSGIAAGCEEAGCALLGGETAEHPGVMEPNEYDVSATSVGVVEEANLLGPD
HHHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCCCC
RVRPGDVVIAMASSGLHSNGYSLARHVLLDTKKLPLDGHIDSLGRTLGEELLEPTRIYAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
DCLKLASECDVHTFAHITGGGLAANLARVIPEGLVAELERSSWTPGPIFRLIQEEGQVSQ
HHHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
EEMEKTFNMGVGMVAVVAEDDAERAMAMLTARHIDAWRLGEVRPAEDGKSGAVLSGEYRT
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCC
PVQG
CCCC
>Mature Secondary Structure 
SEQPENTPAQAAGASYAAAGVDIEAGDRAVELFAPLAKKATRPEVRGGLGGFAGLFALG
CCCCCCCCHHHCCCCHHHCCCEECCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCC
NYEKPLLAASSDGVGTKLAVAQAMDKHDTIGRDLVAMCVDDLVVCGAEPLFLQDYIAIGK
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VVPEHVASIVSGIAAGCEEAGCALLGGETAEHPGVMEPNEYDVSATSVGVVEEANLLGPD
HHHHHHHHHHHHHHHCHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHCCHHHHCCCCCCC
RVRPGDVVIAMASSGLHSNGYSLARHVLLDTKKLPLDGHIDSLGRTLGEELLEPTRIYAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
DCLKLASECDVHTFAHITGGGLAANLARVIPEGLVAELERSSWTPGPIFRLIQEEGQVSQ
HHHHHHHHCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
EEMEKTFNMGVGMVAVVAEDDAERAMAMLTARHIDAWRLGEVRPAEDGKSGAVLSGEYRT
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCC
PVQG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA