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The map label for this gene is tetA [H]

Identifier: 68535426

GI number: 68535426

Start: 433897

End: 435438

Strand: Direct

Name: tetA [H]

Synonym: jk0361

Alternate gene names: 68535426

Gene position: 433897-435438 (Clockwise)

Preceding gene: 68535424

Following gene: 68535427

Centisome position: 17.62

GC content: 68.55

Gene sequence:

>1542_bases
ATGAAGACGTACAGCTGGTTCGTCCCGCCCGCGCCGCCAGCGGACGATCCGGCGCGGCTCCACCCAGCACGCTGGAGCAG
CGGGAACCGTGTGGTCAGGGACATGGTAGGCGCATACCCGGGCGTGCTAGTGCTGCACATTCTGAGCTACCTCATCGGCA
CCGGCATCTCCGCGTTTGTGCCGGTGGTGGTGGGCATGATCGTGGACGGCCTGGTGGGGGAAGAAAAGTTCAACGCATGG
TGGCTCTTCGCAGTATTGGTCGGCATCTTCATCATCCAGTTCATCGGCGAGGCCACCGGCGACGGCCTGGCCACAGCCTC
GGTGCGCCGCGTGACCCACAACGCGCAGCAGCACCTGTCCTCGGGCGTGCTGCGCCGCGGGGCGGGAGCGATGAGCCCCG
GCACGGTGCTCAACACCATCGACGCGGACGCGAACACCGTCGGTCGATACCGCGAGCTGCTGTCGTTTCCGCTGATGGCC
ATCGGCTACGCGGCCGGCGCGATGGTGGCGATGTGGTCGGTCTCCCCGTGGATCTCGCTGGCCATCCCAGCCAGCGCGCT
GATTATCGCCCTGTTCGCCGCGTGGACCGCGGGGCCGGTGACGCGGGTGTCGCTGAAGCGCCGCGCTGCGGAGGCGGATG
TTGCTGGCTTGGCCACGGATGCGTCGCAAGGCATCCGCACCGTCAAAGGCCTCGGCGCGGGCGCAACCGTGGCCGAGCGT
TTTCACTCGGAAACGGCGAAGGCGAAGCGGTTGATGCTCACGCACCTGCGTGTGGAGGTCTGGCTGGGTTTTGCCAGGTT
CTGCGTGGCGTGGCTGTGCAACCTTGCCATCGTGGGCTTGAGCGCGTGGATGACGCTGCGCGGGGAGATCACCCCGGGGC
AGCTGACATCTGTGGCACTGTTGGTGCCGCCTGCGTTGGACATGGCGGGCTTCGCGTTCGGCGACCTGGCAAGTGGGTGG
GGCAGGGCCGTGGCGAGCGGTCAACGCATCGAGCAGCTGCACCACGCGGGCGATGACGCGGCGGGGCCTGAGCCGACAGA
CACCCCGGTCCCAGGCGCGGGTCTGTGGATTCTCGAGCCGGCGGAGCGTTCCTACGCCACCGCCGCCGCGTGGGCGCAGC
GCGCAGACGTGCTGTTCCCGCCGCACACCGTCAACGTGTTTGAGGGCACCATCGCAGACAACGTGAACCCGCGCGGGGAT
GTGCCGGAGGACGTCGTCAAGCAGGCGCTCGCCGCCGCCCACTGCCAAGACATCCTCCGCAGGCTCGGCGGCATAGACGC
AGGCGGCGAGTTGCCGGACGCACCGCTGGGCGAGGCCGGCCTGAATCTCTCCGGCGGGCAGCGGCAGCGCGTCGCGCTTG
CTAGGGCGCTCGCCGCCGACTCGGACGTGCTCATCCTGGACGACCCGACCACTGGCCTCGATTCCGTGACACAGGCGGAC
GTCGTGGCAGCCGTCGCCGCGCTCAGAGCAGACAAAACCACCGTGGTCATCACCGGAAACGCCGCGTGGCAGCACGCTGG
AACCGAATTGGAGGTGGCGTAA

Upstream 100 bases:

>100_bases
ACCTACAGGTCAATCCGTGAAAATCCGCGATTCCGGACACACTTTTTGACCCTTAACCCAATATGCTAGATTTTCCAGAA
TGATGCCACCACCGCGCAGA

Downstream 100 bases:

>100_bases
ATGGCGCGCGAATACGAACGCACTGACGCGGTCGCCCCCGCGAGCGTGAAGGAGACCTTCGCGTACCTGTCTGCGCTACC
CAACGCTCTGGACAAGCGCT

Product: ABC-type transport system TetA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGTGISAFVPVVVGMIVDGLVGEEKFNAW
WLFAVLVGIFIIQFIGEATGDGLATASVRRVTHNAQQHLSSGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMA
IGYAAGAMVAMWSVSPWISLAIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVAER
FHSETAKAKRLMLTHLRVEVWLGFARFCVAWLCNLAIVGLSAWMTLRGEITPGQLTSVALLVPPALDMAGFAFGDLASGW
GRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEPAERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGD
VPEDVVKQALAAAHCQDILRRLGGIDAGGELPDAPLGEAGLNLSGGQRQRVALARALAADSDVLILDDPTTGLDSVTQAD
VVAAVAALRADKTTVVITGNAAWQHAGTELEVA

Sequences:

>Translated_513_residues
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGTGISAFVPVVVGMIVDGLVGEEKFNAW
WLFAVLVGIFIIQFIGEATGDGLATASVRRVTHNAQQHLSSGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMA
IGYAAGAMVAMWSVSPWISLAIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVAER
FHSETAKAKRLMLTHLRVEVWLGFARFCVAWLCNLAIVGLSAWMTLRGEITPGQLTSVALLVPPALDMAGFAFGDLASGW
GRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEPAERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGD
VPEDVVKQALAAAHCQDILRRLGGIDAGGELPDAPLGEAGLNLSGGQRQRVALARALAADSDVLILDDPTTGLDSVTQAD
VVAAVAALRADKTTVVITGNAAWQHAGTELEVA
>Mature_513_residues
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGTGISAFVPVVVGMIVDGLVGEEKFNAW
WLFAVLVGIFIIQFIGEATGDGLATASVRRVTHNAQQHLSSGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMA
IGYAAGAMVAMWSVSPWISLAIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVAER
FHSETAKAKRLMLTHLRVEVWLGFARFCVAWLCNLAIVGLSAWMTLRGEITPGQLTSVALLVPPALDMAGFAFGDLASGW
GRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEPAERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGD
VPEDVVKQALAAAHCQDILRRLGGIDAGGELPDAPLGEAGLNLSGGQRQRVALARALAADSDVLILDDPTTGLDSVTQAD
VVAAVAALRADKTTVVITGNAAWQHAGTELEVA

Specific function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9961250, Length=113, Percent_Identity=38.9380530973451, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4505771, Length=113, Percent_Identity=38.9380530973451, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI9961252, Length=113, Percent_Identity=38.9380530973451, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI42741659, Length=113, Percent_Identity=37.1681415929204, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI9955963, Length=125, Percent_Identity=34.4, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1787143, Length=137, Percent_Identity=35.036496350365, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787112, Length=131, Percent_Identity=35.1145038167939, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786654, Length=113, Percent_Identity=39.8230088495575, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=116, Percent_Identity=34.4827586206897, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115535101, Length=116, Percent_Identity=39.6551724137931, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=113, Percent_Identity=40.7079646017699, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71984940, Length=113, Percent_Identity=34.5132743362832, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=113, Percent_Identity=40.7079646017699, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=114, Percent_Identity=32.4561403508772, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320339, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323014, Length=135, Percent_Identity=31.8518518518519, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85726357, Length=65, Percent_Identity=46.1538461538462, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011917
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 53744; Mature: 53744

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00211 ABC_TRANSPORTER_1 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGTGISAFV
CCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
PVVVGMIVDGLVGEEKFNAWWLFAVLVGIFIIQFIGEATGDGLATASVRRVTHNAQQHLS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMAIGYAAGAMVAMWSVSPWISL
HHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVAER
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FHSETAKAKRLMLTHLRVEVWLGFARFCVAWLCNLAIVGLSAWMTLRGEITPGQLTSVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHEEEE
LVPPALDMAGFAFGDLASGWGRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEP
ECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECC
AERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGDVPEDVVKQALAAAHCQDILR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RLGGIDAGGELPDAPLGEAGLNLSGGQRQRVALARALAADSDVLILDDPTTGLDSVTQAD
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
VVAAVAALRADKTTVVITGNAAWQHAGTELEVA
HHHHHHHHHCCCEEEEEECCCHHHCCCCEEECC
>Mature Secondary Structure
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGTGISAFV
CCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
PVVVGMIVDGLVGEEKFNAWWLFAVLVGIFIIQFIGEATGDGLATASVRRVTHNAQQHLS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
SGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMAIGYAAGAMVAMWSVSPWISL
HHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
AIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVAER
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FHSETAKAKRLMLTHLRVEVWLGFARFCVAWLCNLAIVGLSAWMTLRGEITPGQLTSVAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHEEEE
LVPPALDMAGFAFGDLASGWGRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEP
ECCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECC
AERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGDVPEDVVKQALAAAHCQDILR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RLGGIDAGGELPDAPLGEAGLNLSGGQRQRVALARALAADSDVLILDDPTTGLDSVTQAD
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
VVAAVAALRADKTTVVITGNAAWQHAGTELEVA
HHHHHHHHHCCCEEEEEECCCHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA