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The map label for this gene is tcsR1 [H]

Identifier: 68535406

GI number: 68535406

Start: 410013

End: 410714

Strand: Direct

Name: tcsR1 [H]

Synonym: jk0341

Alternate gene names: 68535406

Gene position: 410013-410714 (Clockwise)

Preceding gene: 68535403

Following gene: 68535407

Centisome position: 16.65

GC content: 58.55

Gene sequence:

>702_bases
ATGCCAAACGCCCAGCCGGTGAAGGTCCTCGTCGTCGACGACGAGGCTAATATCTCTGACCTCCTTAAAGTAAGCCTGAA
GTTTCAGGGATTCGACGTGGAAACGGCCGACAATGGCCAGGACGCGCTGGCGCTGGCGGCAACCTACAAGCCCGACGCCT
TCATTCTGGACGTCATGATGCCCGGCATGGATGGCTTCACCCTCCTCAATAAGCTCCGCGCCGCAGGCCACGATGCCCCG
GCACTGTTCCTTACCGCCAAGGACGGCGTGGAGGATCGAATCCACGGCCTTACTATCGGCGCCGATGATTATGTGACCAA
GCCATTCAGCCTAGAAGAGGTCATTACCCGACTGCGCGTGATCCTGCGCCGGGTGTCCTCCGAAGATGAGCAGGAATCCA
GCCTGATCACCTACGAGGACATCACCCTGGATGACGATATGCACGAGGTCACGAAGGCTGGCGAGATCGTCGAACTATCG
CCCACGGAGTTCAAGCTGCTGCGCTACCTACTGGTCAACGCCGAAGTTGTGCTGAGCAAGGCGAAGATCCTGGACCACGT
GTGGAACTACGACTTTGGCGGCGACGGCAACGTCGTCGAGTCTTATGTCTCCTACCTGCGGCGCAAGATCGACAAGGAAG
AGCCTCACCTCATTCAGACGGTTCGTGGCGTGGGGTACGTATTGCGTAAGCCCCGCGCTTAA

Upstream 100 bases:

>100_bases
GGAAGGACGAGATGGGGAAGCTACTGGAAGGTTCACAGCAAGCATCCAGCTATCATGCAGTTAGACGCTAATTCTCTGCA
GCACAATAAGGTTCATGACA

Downstream 100 bases:

>100_bases
GACCTGATTCCTATGTCCAACGCGCAAAACTCTAGTGCGCCTGATTCTGCTGTGGCTGATGCAGGCTCCGCCGCTCCTGT
TCGTTCCGGCCACCCGGGGC

Product: two-component system response regulator TcsR1

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MPNAQPVKVLVVDDEANISDLLKVSLKFQGFDVETADNGQDALALAATYKPDAFILDVMMPGMDGFTLLNKLRAAGHDAP
ALFLTAKDGVEDRIHGLTIGADDYVTKPFSLEEVITRLRVILRRVSSEDEQESSLITYEDITLDDDMHEVTKAGEIVELS
PTEFKLLRYLLVNAEVVLSKAKILDHVWNYDFGGDGNVVESYVSYLRRKIDKEEPHLIQTVRGVGYVLRKPRA

Sequences:

>Translated_233_residues
MPNAQPVKVLVVDDEANISDLLKVSLKFQGFDVETADNGQDALALAATYKPDAFILDVMMPGMDGFTLLNKLRAAGHDAP
ALFLTAKDGVEDRIHGLTIGADDYVTKPFSLEEVITRLRVILRRVSSEDEQESSLITYEDITLDDDMHEVTKAGEIVELS
PTEFKLLRYLLVNAEVVLSKAKILDHVWNYDFGGDGNVVESYVSYLRRKIDKEEPHLIQTVRGVGYVLRKPRA
>Mature_232_residues
PNAQPVKVLVVDDEANISDLLKVSLKFQGFDVETADNGQDALALAATYKPDAFILDVMMPGMDGFTLLNKLRAAGHDAPA
LFLTAKDGVEDRIHGLTIGADDYVTKPFSLEEVITRLRVILRRVSSEDEQESSLITYEDITLDDDMHEVTKAGEIVELSP
TEFKLLRYLLVNAEVVLSKAKILDHVWNYDFGGDGNVVESYVSYLRRKIDKEEPHLIQTVRGVGYVLRKPRA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.8230088495575, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=37.8378378378378, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.5555555555556, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.9366515837104, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.1990950226244, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=38.1165919282511, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=34.3612334801762, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=31.5315315315315, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.8385650224215, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=40.1869158878505, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=32, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787487, Length=178, Percent_Identity=28.6516853932584, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790437, Length=125, Percent_Identity=31.2, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI145693157, Length=117, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=112, Percent_Identity=36.6071428571429, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26008; Mature: 25877

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNAQPVKVLVVDDEANISDLLKVSLKFQGFDVETADNGQDALALAATYKPDAFILDVMM
CCCCCCEEEEEEECCCCHHHHHHHHEEEECCEECCCCCCCCEEEEEEECCCCEEEEEECC
PGMDGFTLLNKLRAAGHDAPALFLTAKDGVEDRIHGLTIGADDYVTKPFSLEEVITRLRV
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCEEEECCCCCCCCCCCHHHHHHHHHH
ILRRVSSEDEQESSLITYEDITLDDDMHEVTKAGEIVELSPTEFKLLRYLLVNAEVVLSK
HHHHHCCCCCHHCCEEEEECCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHH
AKILDHVWNYDFGGDGNVVESYVSYLRRKIDKEEPHLIQTVRGVGYVLRKPRA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PNAQPVKVLVVDDEANISDLLKVSLKFQGFDVETADNGQDALALAATYKPDAFILDVMM
CCCCCEEEEEEECCCCHHHHHHHHEEEECCEECCCCCCCCEEEEEEECCCCEEEEEECC
PGMDGFTLLNKLRAAGHDAPALFLTAKDGVEDRIHGLTIGADDYVTKPFSLEEVITRLRV
CCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCEEEECCCCCCCCCCCHHHHHHHHHH
ILRRVSSEDEQESSLITYEDITLDDDMHEVTKAGEIVELSPTEFKLLRYLLVNAEVVLSK
HHHHHCCCCCHHCCEEEEECCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHH
AKILDHVWNYDFGGDGNVVESYVSYLRRKIDKEEPHLIQTVRGVGYVLRKPRA
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA