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The map label for this gene is tcsS1 [H]

Identifier: 68535407

GI number: 68535407

Start: 410727

End: 412337

Strand: Direct

Name: tcsS1 [H]

Synonym: jk0342

Alternate gene names: 68535407

Gene position: 410727-412337 (Clockwise)

Preceding gene: 68535406

Following gene: 68535411

Centisome position: 16.68

GC content: 62.01

Gene sequence:

>1611_bases
ATGTCCAACGCGCAAAACTCTAGTGCGCCTGATTCTGCTGTGGCTGATGCAGGCTCCGCCGCTCCTGTTCGTTCCGGCCA
CCCGGGGCACTTTTTGTCACACTATCCGCTGCGTATCTCCCTGGTCGTGGTCATTGCGGTGCTGGTCGCTATGGGGCTGA
CAGTTTCCGGCGTGTCCGTGACAACTACTCTGCAGCGCTTCCTTATTCAAAGGGTTGATGAGCAGCTGGATCAGGCGACG
AACGGTTGGGCCCATCGGTCCGGCCTCGCCGACGGAACAAACAGTGGTACAACAAACGGCACCAACAGTGGCACAACAAA
TGGAGAAAGCACACAGGGCGGTAGCGAAAGCAGTGCTTTAGGGTCGGAGGGATTCGGTGTACTCAACCTGCAGCAGCCCC
CGAGCCCCGTCACCGGTGTCACCCGCCCGCCCAGCGACTTCTACATTATGGTGGTCGACGACCAGATCTCCTACGAGTAT
TTCAACTCCCCGCTGAAGGCCCGCCCCGAGATCCGCGGACTGGGAAATCCCACCATGCCAGTGACTGTCGGTTCACGCGA
GGATTCCGAGCCGCATATTAGCTGGCGCGCCACAAGTTTCCGAAATGACGACGGCACCATTACCATCGTCGCTTTGCCTT
TGGCGGAAGAAGAGCACATTATCTCCCGCCTTGTGCTGCTGCAGGCAGTCATTGGCCTGACTGTTGTCGCCTTCGTCATC
CTGGCATCGATGTATCTGGTGCGCCGCGCTTTGCGACCGCTGAACGAGGTGGAGCTGACGGCGTCAAAAATTTCGAACGG
CGACCTCGGGCAGCGCGTGCCGAACTGGCGGCCCAACACAGAGGTCGGGCGGCTTTCGCAGGCGCTCAACAAGATGCTCG
CGCAGATCCAAACGGCGTTCGTCGCCATTGGTGCTTCGGAAAGGCAGGCTCGCCGCTCCGAGGCATCGATGCGCCGCTTC
ATCGGGGATGCTTCGCACGAGCTGCGCACGCCGTTGACGTCGGTGCGCGGCTACGCGGAGCTGTACCAATCGGGTGCTAC
TGATGACGCCCCCATGGTCATTGACCGGATTTCTGAAGAGGCTGGCCGCATGAGTCTGCTGGTCGAAGACCTCCTCGCGC
TGGTCCGCATGGACGAGGGGCGACCGCTGGCGAAGAACCGCGTGGACATGCTGGAACTGGTGCTGGAAACTGCGGAGTCG
GCGCGGGCAGGCTTCCCGAACCGCACGGTGCAGGTCGTCAACGAAACCGGGGACGTGCCTATCGTCATCGGCGACGTCAA
CCGCCTGCACCAGGTGCTGGGCAACCTGGTGACCAATGCGCTGCGGCACGCGGGTGAAGACGCTGAGGTGAAGCTGCGCC
TGGACAAGCGAGATGGCCACGTGATCGTGGACGTGGAGGACAATGGCCGGGGAATTCCGGCTGAAGATGTGCCGCACCTG
TTTGAAAGGTTCTACCGCCCGGACGTTTCGCGCTCCCGCGCTTCGGGTGGATCGGGGCTGGGGCTGTCGATCGTCAAGGG
GCTGGTGGAGGCCCACGGCGGCACGGTCTCCGTGGACAGCGAAGAAGGCCAGGGCACGCGCTTCCGGATCGATCTGCCCG
AAGCGGAATAA

Upstream 100 bases:

>100_bases
CCTGCGGCGCAAGATCGACAAGGAAGAGCCTCACCTCATTCAGACGGTTCGTGGCGTGGGGTACGTATTGCGTAAGCCCC
GCGCTTAAGACCTGATTCCT

Downstream 100 bases:

>100_bases
CACTCCGTGGGGTATGCGAGGGGGGGTGTCCCTATGTTTTTGTCAAGTGCCAGACCGATGTTGACGAGCACAGTCTTGGG
AGTAGTTTCTTAGGCGTGCC

Product: two-component system sensor kinase TcsS1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSNAQNSSAPDSAVADAGSAAPVRSGHPGHFLSHYPLRISLVVVIAVLVAMGLTVSGVSVTTTLQRFLIQRVDEQLDQAT
NGWAHRSGLADGTNSGTTNGTNSGTTNGESTQGGSESSALGSEGFGVLNLQQPPSPVTGVTRPPSDFYIMVVDDQISYEY
FNSPLKARPEIRGLGNPTMPVTVGSREDSEPHISWRATSFRNDDGTITIVALPLAEEEHIISRLVLLQAVIGLTVVAFVI
LASMYLVRRALRPLNEVELTASKISNGDLGQRVPNWRPNTEVGRLSQALNKMLAQIQTAFVAIGASERQARRSEASMRRF
IGDASHELRTPLTSVRGYAELYQSGATDDAPMVIDRISEEAGRMSLLVEDLLALVRMDEGRPLAKNRVDMLELVLETAES
ARAGFPNRTVQVVNETGDVPIVIGDVNRLHQVLGNLVTNALRHAGEDAEVKLRLDKRDGHVIVDVEDNGRGIPAEDVPHL
FERFYRPDVSRSRASGGSGLGLSIVKGLVEAHGGTVSVDSEEGQGTRFRIDLPEAE

Sequences:

>Translated_536_residues
MSNAQNSSAPDSAVADAGSAAPVRSGHPGHFLSHYPLRISLVVVIAVLVAMGLTVSGVSVTTTLQRFLIQRVDEQLDQAT
NGWAHRSGLADGTNSGTTNGTNSGTTNGESTQGGSESSALGSEGFGVLNLQQPPSPVTGVTRPPSDFYIMVVDDQISYEY
FNSPLKARPEIRGLGNPTMPVTVGSREDSEPHISWRATSFRNDDGTITIVALPLAEEEHIISRLVLLQAVIGLTVVAFVI
LASMYLVRRALRPLNEVELTASKISNGDLGQRVPNWRPNTEVGRLSQALNKMLAQIQTAFVAIGASERQARRSEASMRRF
IGDASHELRTPLTSVRGYAELYQSGATDDAPMVIDRISEEAGRMSLLVEDLLALVRMDEGRPLAKNRVDMLELVLETAES
ARAGFPNRTVQVVNETGDVPIVIGDVNRLHQVLGNLVTNALRHAGEDAEVKLRLDKRDGHVIVDVEDNGRGIPAEDVPHL
FERFYRPDVSRSRASGGSGLGLSIVKGLVEAHGGTVSVDSEEGQGTRFRIDLPEAE
>Mature_535_residues
SNAQNSSAPDSAVADAGSAAPVRSGHPGHFLSHYPLRISLVVVIAVLVAMGLTVSGVSVTTTLQRFLIQRVDEQLDQATN
GWAHRSGLADGTNSGTTNGTNSGTTNGESTQGGSESSALGSEGFGVLNLQQPPSPVTGVTRPPSDFYIMVVDDQISYEYF
NSPLKARPEIRGLGNPTMPVTVGSREDSEPHISWRATSFRNDDGTITIVALPLAEEEHIISRLVLLQAVIGLTVVAFVIL
ASMYLVRRALRPLNEVELTASKISNGDLGQRVPNWRPNTEVGRLSQALNKMLAQIQTAFVAIGASERQARRSEASMRRFI
GDASHELRTPLTSVRGYAELYQSGATDDAPMVIDRISEEAGRMSLLVEDLLALVRMDEGRPLAKNRVDMLELVLETAESA
RAGFPNRTVQVVNETGDVPIVIGDVNRLHQVLGNLVTNALRHAGEDAEVKLRLDKRDGHVIVDVEDNGRGIPAEDVPHLF
ERFYRPDVSRSRASGGSGLGLSIVKGLVEAHGGTVSVDSEEGQGTRFRIDLPEAE

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=32.8719723183391, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1786783, Length=377, Percent_Identity=31.2997347480106, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=36.0869565217391, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1790346, Length=290, Percent_Identity=32.7586206896552, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1787894, Length=313, Percent_Identity=30.3514376996805, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1789149, Length=341, Percent_Identity=26.6862170087977, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=31.1320754716981, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788279, Length=346, Percent_Identity=27.1676300578035, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=267, Percent_Identity=28.0898876404494, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=29.8245614035088, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.4285714285714, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI87081816, Length=346, Percent_Identity=28.6127167630058, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1789403, Length=347, Percent_Identity=27.6657060518732, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=313, Percent_Identity=28.7539936102236, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=217, Percent_Identity=27.6497695852535, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1790300, Length=245, Percent_Identity=30.2040816326531, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1789808, Length=301, Percent_Identity=24.2524916943522, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=25.531914893617, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57641; Mature: 57509

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAQNSSAPDSAVADAGSAAPVRSGHPGHFLSHYPLRISLVVVIAVLVAMGLTVSGVSV
CCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
TTTLQRFLIQRVDEQLDQATNGWAHRSGLADGTNSGTTNGTNSGTTNGESTQGGSESSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GSEGFGVLNLQQPPSPVTGVTRPPSDFYIMVVDDQISYEYFNSPLKARPEIRGLGNPTMP
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCE
VTVGSREDSEPHISWRATSFRNDDGTITIVALPLAEEEHIISRLVLLQAVIGLTVVAFVI
EEECCCCCCCCCEEEEECCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASMYLVRRALRPLNEVELTASKISNGDLGQRVPNWRPNTEVGRLSQALNKMLAQIQTAF
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAIGASERQARRSEASMRRFIGDASHELRTPLTSVRGYAELYQSGATDDAPMVIDRISEE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AGRMSLLVEDLLALVRMDEGRPLAKNRVDMLELVLETAESARAGFPNRTVQVVNETGDVP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEE
IVIGDVNRLHQVLGNLVTNALRHAGEDAEVKLRLDKRDGHVIVDVEDNGRGIPAEDVPHL
EEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHH
FERFYRPDVSRSRASGGSGLGLSIVKGLVEAHGGTVSVDSEEGQGTRFRIDLPEAE
HHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SNAQNSSAPDSAVADAGSAAPVRSGHPGHFLSHYPLRISLVVVIAVLVAMGLTVSGVSV
CCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHH
TTTLQRFLIQRVDEQLDQATNGWAHRSGLADGTNSGTTNGTNSGTTNGESTQGGSESSAL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GSEGFGVLNLQQPPSPVTGVTRPPSDFYIMVVDDQISYEYFNSPLKARPEIRGLGNPTMP
CCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHCCCCCCCCCCCCCCCCCCE
VTVGSREDSEPHISWRATSFRNDDGTITIVALPLAEEEHIISRLVLLQAVIGLTVVAFVI
EEECCCCCCCCCEEEEECCEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
LASMYLVRRALRPLNEVELTASKISNGDLGQRVPNWRPNTEVGRLSQALNKMLAQIQTAF
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAIGASERQARRSEASMRRFIGDASHELRTPLTSVRGYAELYQSGATDDAPMVIDRISEE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AGRMSLLVEDLLALVRMDEGRPLAKNRVDMLELVLETAESARAGFPNRTVQVVNETGDVP
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEE
IVIGDVNRLHQVLGNLVTNALRHAGEDAEVKLRLDKRDGHVIVDVEDNGRGIPAEDVPHL
EEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHH
FERFYRPDVSRSRASGGSGLGLSIVKGLVEAHGGTVSVDSEEGQGTRFRIDLPEAE
HHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]