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The map label for this gene is galK [H]

Identifier: 68535356

GI number: 68535356

Start: 354091

End: 355365

Strand: Direct

Name: galK [H]

Synonym: jk0291

Alternate gene names: 68535356

Gene position: 354091-355365 (Clockwise)

Preceding gene: 68535355

Following gene: 68535357

Centisome position: 14.38

GC content: 66.51

Gene sequence:

>1275_bases
ATGCCAACTAACGAAACCCCCACAAACCAAACCAGCGCAGCACAAAACGCTGGTACCCCGCACTGGCTGCAGACCCGCTC
CGAGAAGCAGGGCACTGCCGACGTGCAGTCCCTGTTCCAACAGGTCTACGGCTATGAGCCGGAGGGTGTGTGGTCCGCGC
CGGGGCGCGTGAACCTGATCGGCGAGCACGTCGACTATGCAGATGGCATCAGCCTGCCTTTCGCACTTTCGCAGCGCACC
TACGTGGCAGCTGCCAAGAACGACGACGGCGTGTACCGGGTGGCTTCCCGCTTCGGTGACCCGGCGGAGATTGTTCACTT
TGAGATCCCCGTCGCTGAGGTCGGCCCCGGTAACCCCGCCAACTGGGCGGGGTACGCAGTCGGCGCTATCTGGGCAGCTG
CGGAGGCTGGTCTGATGCCCGCCGGTGGATTGGACCTCGCCATTGAGTCCGACGTTCCCGTCGGTGCGGGGCTTTCCAGT
TCCGCAGCGCTGGAATGCTCGGCGGCTCTCGCGGCCTATGACCTATACGGCGGTGTGCCCCTCGATGATGCGGTTCGCAG
CGGGCTCATGGGGGCATCCATAAGAGCAGAGAACGAGGTAGTCGGCGCTTCGACGGGCGGGCTTGATCAGCGTATTTCGC
TGTTCGGCCAGGTCGGCCACGCGCTGGCCATCGACTTCGCCGAAGACAGCGCCACCCAGGTGCCTTTCGACATCGCGGCG
CGCGGATTGGCGATCCTCATTATGAACACGAACGCCCCACACCAGCTGAACGACGGGCAATACGCCGCGCGGCGCGCCGT
GATCGACGGAGTGACCGCCGACCTGGGCGTTAGCAGCCTGCGTTTCGCCGAGGAGGCCGAGGATGCCTCCGTGGGCTGGG
CCAAGGCCAACAACATGGATCCGGTGGTGGTGGCCGCCCGCGTGCGCCACGTGGTCAGCGAGATCGACCGCACCGCTGAG
GCGATCCGCCAGGTCAGCGCCGGGGACATGGAGGCCTTCGGACGGTCGATGCAGGGCAGTCACGCCTCCCTGCGCGATGA
CTACGAGGTCACTGTCCCGGAGCTGGATACTGCCGTGGACGTTGCGATGGCCGAGGGCGCGCTGGGTGCCCGCATGACCG
GCGGCGGTTTCGGCGGCTCCGCGATTGCGCTGCTGCGTGAGGATCAGGTGGAGGCGACGGCCGCGGCAGTGGCCAAGGCC
TTCGCGGAGAAGGGATTCAACGAGCCCGAGTTCGTGGTCGCCCTGCCGAGCGACGGCGCGCACCGGAACGCTTAA

Upstream 100 bases:

>100_bases
CGCATGAAGTTCTTGGCCGGTAGCGAGTCGGGCCAGGAGGCCTGGATCTCCGACACCACCCCGGAGAGGATCGCCGAGCG
CTTCCGGGAGGTCGCCGACA

Downstream 100 bases:

>100_bases
GCGGCTCGCATTGAGTAACGCTTACGCGAGCAGCGCTCGCGCGCCGCTCGCGCGTTGCCCGGGCGCCATATTGGCGCCGA
GCAAAGTAACAGCTAAATAG

Product: hypothetical protein

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MPTNETPTNQTSAAQNAGTPHWLQTRSEKQGTADVQSLFQQVYGYEPEGVWSAPGRVNLIGEHVDYADGISLPFALSQRT
YVAAAKNDDGVYRVASRFGDPAEIVHFEIPVAEVGPGNPANWAGYAVGAIWAAAEAGLMPAGGLDLAIESDVPVGAGLSS
SAALECSAALAAYDLYGGVPLDDAVRSGLMGASIRAENEVVGASTGGLDQRISLFGQVGHALAIDFAEDSATQVPFDIAA
RGLAILIMNTNAPHQLNDGQYAARRAVIDGVTADLGVSSLRFAEEAEDASVGWAKANNMDPVVVAARVRHVVSEIDRTAE
AIRQVSAGDMEAFGRSMQGSHASLRDDYEVTVPELDTAVDVAMAEGALGARMTGGGFGGSAIALLREDQVEATAAAVAKA
FAEKGFNEPEFVVALPSDGAHRNA

Sequences:

>Translated_424_residues
MPTNETPTNQTSAAQNAGTPHWLQTRSEKQGTADVQSLFQQVYGYEPEGVWSAPGRVNLIGEHVDYADGISLPFALSQRT
YVAAAKNDDGVYRVASRFGDPAEIVHFEIPVAEVGPGNPANWAGYAVGAIWAAAEAGLMPAGGLDLAIESDVPVGAGLSS
SAALECSAALAAYDLYGGVPLDDAVRSGLMGASIRAENEVVGASTGGLDQRISLFGQVGHALAIDFAEDSATQVPFDIAA
RGLAILIMNTNAPHQLNDGQYAARRAVIDGVTADLGVSSLRFAEEAEDASVGWAKANNMDPVVVAARVRHVVSEIDRTAE
AIRQVSAGDMEAFGRSMQGSHASLRDDYEVTVPELDTAVDVAMAEGALGARMTGGGFGGSAIALLREDQVEATAAAVAKA
FAEKGFNEPEFVVALPSDGAHRNA
>Mature_423_residues
PTNETPTNQTSAAQNAGTPHWLQTRSEKQGTADVQSLFQQVYGYEPEGVWSAPGRVNLIGEHVDYADGISLPFALSQRTY
VAAAKNDDGVYRVASRFGDPAEIVHFEIPVAEVGPGNPANWAGYAVGAIWAAAEAGLMPAGGLDLAIESDVPVGAGLSSS
AALECSAALAAYDLYGGVPLDDAVRSGLMGASIRAENEVVGASTGGLDQRISLFGQVGHALAIDFAEDSATQVPFDIAAR
GLAILIMNTNAPHQLNDGQYAARRAVIDGVTADLGVSSLRFAEEAEDASVGWAKANNMDPVVVAARVRHVVSEIDRTAEA
IRQVSAGDMEAFGRSMQGSHASLRDDYEVTVPELDTAVDVAMAEGALGARMTGGGFGGSAIALLREDQVEATAAAVAKAF
AEKGFNEPEFVVALPSDGAHRNA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=396, Percent_Identity=39.6464646464646, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4503897, Length=428, Percent_Identity=27.803738317757, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI48527957, Length=428, Percent_Identity=27.803738317757, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1786972, Length=392, Percent_Identity=38.7755102040816, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71989053, Length=417, Percent_Identity=29.2565947242206, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319494, Length=228, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=30.2904564315353, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24661292, Length=438, Percent_Identity=27.8538812785388, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21355577, Length=438, Percent_Identity=27.8538812785388, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24661285, Length=438, Percent_Identity=27.8538812785388, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43997; Mature: 43866

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNETPTNQTSAAQNAGTPHWLQTRSEKQGTADVQSLFQQVYGYEPEGVWSAPGRVNLI
CCCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
GEHVDYADGISLPFALSQRTYVAAAKNDDGVYRVASRFGDPAEIVHFEIPVAEVGPGNPA
ECCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCCEEEEECCHHCCCCCCCC
NWAGYAVGAIWAAAEAGLMPAGGLDLAIESDVPVGAGLSSSAALECSAALAAYDLYGGVP
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
LDDAVRSGLMGASIRAENEVVGASTGGLDQRISLFGQVGHALAIDFAEDSATQVPFDIAA
HHHHHHCCCCCCEEECCCCEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHC
RGLAILIMNTNAPHQLNDGQYAARRAVIDGVTADLGVSSLRFAEEAEDASVGWAKANNMD
CCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
PVVVAARVRHVVSEIDRTAEAIRQVSAGDMEAFGRSMQGSHASLRDDYEVTVPELDTAVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCHHHH
VAMAEGALGARMTGGGFGGSAIALLREDQVEATAAAVAKAFAEKGFNEPEFVVALPSDGA
HHHHCCCCCCEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
HRNA
CCCC
>Mature Secondary Structure 
PTNETPTNQTSAAQNAGTPHWLQTRSEKQGTADVQSLFQQVYGYEPEGVWSAPGRVNLI
CCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEE
GEHVDYADGISLPFALSQRTYVAAAKNDDGVYRVASRFGDPAEIVHFEIPVAEVGPGNPA
ECCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCCEEEEECCHHCCCCCCCC
NWAGYAVGAIWAAAEAGLMPAGGLDLAIESDVPVGAGLSSSAALECSAALAAYDLYGGVP
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
LDDAVRSGLMGASIRAENEVVGASTGGLDQRISLFGQVGHALAIDFAEDSATQVPFDIAA
HHHHHHCCCCCCEEECCCCEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHC
RGLAILIMNTNAPHQLNDGQYAARRAVIDGVTADLGVSSLRFAEEAEDASVGWAKANNMD
CCEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCC
PVVVAARVRHVVSEIDRTAEAIRQVSAGDMEAFGRSMQGSHASLRDDYEVTVPELDTAVD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCHHHH
VAMAEGALGARMTGGGFGGSAIALLREDQVEATAAAVAKAFAEKGFNEPEFVVALPSDGA
HHHHCCCCCCEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
HRNA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]