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The map label for this gene is folP [H]

Identifier: 68535345

GI number: 68535345

Start: 344364

End: 345269

Strand: Direct

Name: folP [H]

Synonym: jk0280

Alternate gene names: 68535345

Gene position: 344364-345269 (Clockwise)

Preceding gene: 68535344

Following gene: 68535346

Centisome position: 13.98

GC content: 69.43

Gene sequence:

>906_bases
GTGACGGGCTCTGCTGTGACTAGCACCAACGCGAACGACCCCCAGCGCACCCTCGTGATGGGCATCCTCAACGTCACCGA
GGATTCCTTCTCCGACGGCGGGGCCTACCCGGACACCGCGGCCGCGCTGGCACACGCCGAGGCGATGGTCGCTGACGGTG
CGGACATCATCGACGTCGGCGGGGAATCCACCCGCCCGGGCGCCACTCGCGTTGCCTCGGAGGTCGCGGCCCGCGTCACC
CCCGTCATCGAGGAGCTATCCCGCCGGGGAATCGCCACCAGCATCGACACGATGCGGGCATCCACGGCGCGGGCCGCCTG
GAAAGCGGGCGTCACCTACCTCAACGACGTCTCCGGCGGCCTGGCGGACCCCGACATGCTGCCGCTGGCCGCGGAATCCG
GCCTGCCGATCATTCTGATGCACTGGAACAAGGGAAACGCCGCGGACTTCGCCGGAGCTGAGGGCTACCACGACCACGGC
GAGGACATCGTCGGCCACGTCATCGGTTGGCTCGAGCAGAGGATCGAAGCGGCGGAGGCGGTAGGCGTCACAAAGAAACA
GATCTACCTGGACCCCGGCATCGGGTTCGCGAAGAGTCCGCAGGAAAACTGGCAGCTGCTCGGCGCGACTGAACGACTGG
TGCAGATGGGCTATCCGGTGCTGGTGGGGGCCTCGCGCAAGCGCTTCCTCACCGCGCTGCGCCCCGCGAGCGACGGCAAC
CCCGGCACCCCGGAATCGGCGGACGATGCGACGGCGGCCACCTCCGCGCTGGCGGCGGCAGTTGGCGCATGGGCCGTCCG
GGTGCATAAAGTAGCCCCGACACGGGCCGCAGTGGACGTCGCACACGCCATGGCCACCGGACGCGGCCCCGACATCGACG
AGCAATGGAGGGCGCGACGTGGCTGA

Upstream 100 bases:

>100_bases
GCATCCGCAAGCCCGGCGCCAACACGGTGACCTCTGCGGTTCGTGGCGGATTCCAGAAGAACGCGGCCTCCCGCGCAGAG
GCGATGGCGCTGATCCGGCC

Downstream 100 bases:

>100_bases
CCGCATTGAGCTCATCGGCGTGGAGGCTTTCGGCCACCACGGCGTGTTTTCGGACGAAAAGAACACCGGCCAGAAGTTCA
TCGTGGACATGGTGGTGTGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTGSAVTSTNANDPQRTLVMGILNVTEDSFSDGGAYPDTAAALAHAEAMVADGADIIDVGGESTRPGATRVASEVAARVT
PVIEELSRRGIATSIDTMRASTARAAWKAGVTYLNDVSGGLADPDMLPLAAESGLPIILMHWNKGNAADFAGAEGYHDHG
EDIVGHVIGWLEQRIEAAEAVGVTKKQIYLDPGIGFAKSPQENWQLLGATERLVQMGYPVLVGASRKRFLTALRPASDGN
PGTPESADDATAATSALAAAVGAWAVRVHKVAPTRAAVDVAHAMATGRGPDIDEQWRARRG

Sequences:

>Translated_301_residues
MTGSAVTSTNANDPQRTLVMGILNVTEDSFSDGGAYPDTAAALAHAEAMVADGADIIDVGGESTRPGATRVASEVAARVT
PVIEELSRRGIATSIDTMRASTARAAWKAGVTYLNDVSGGLADPDMLPLAAESGLPIILMHWNKGNAADFAGAEGYHDHG
EDIVGHVIGWLEQRIEAAEAVGVTKKQIYLDPGIGFAKSPQENWQLLGATERLVQMGYPVLVGASRKRFLTALRPASDGN
PGTPESADDATAATSALAAAVGAWAVRVHKVAPTRAAVDVAHAMATGRGPDIDEQWRARRG
>Mature_300_residues
TGSAVTSTNANDPQRTLVMGILNVTEDSFSDGGAYPDTAAALAHAEAMVADGADIIDVGGESTRPGATRVASEVAARVTP
VIEELSRRGIATSIDTMRASTARAAWKAGVTYLNDVSGGLADPDMLPLAAESGLPIILMHWNKGNAADFAGAEGYHDHGE
DIVGHVIGWLEQRIEAAEAVGVTKKQIYLDPGIGFAKSPQENWQLLGATERLVQMGYPVLVGASRKRFLTALRPASDGNP
GTPESADDATAATSALAAAVGAWAVRVHKVAPTRAAVDVAHAMATGRGPDIDEQWRARRG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=284, Percent_Identity=38.3802816901408, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324073, Length=327, Percent_Identity=30.5810397553517, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31329; Mature: 31198

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSAVTSTNANDPQRTLVMGILNVTEDSFSDGGAYPDTAAALAHAEAMVADGADIIDVG
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
GESTRPGATRVASEVAARVTPVIEELSRRGIATSIDTMRASTARAAWKAGVTYLNDVSGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
LADPDMLPLAAESGLPIILMHWNKGNAADFAGAEGYHDHGEDIVGHVIGWLEQRIEAAEA
CCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGVTKKQIYLDPGIGFAKSPQENWQLLGATERLVQMGYPVLVGASRKRFLTALRPASDGN
HCCCHHEEEECCCCCCCCCCHHHHEEHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCC
PGTPESADDATAATSALAAAVGAWAVRVHKVAPTRAAVDVAHAMATGRGPDIDEQWRARR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHCC
G
C
>Mature Secondary Structure 
TGSAVTSTNANDPQRTLVMGILNVTEDSFSDGGAYPDTAAALAHAEAMVADGADIIDVG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
GESTRPGATRVASEVAARVTPVIEELSRRGIATSIDTMRASTARAAWKAGVTYLNDVSGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
LADPDMLPLAAESGLPIILMHWNKGNAADFAGAEGYHDHGEDIVGHVIGWLEQRIEAAEA
CCCCCCCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGVTKKQIYLDPGIGFAKSPQENWQLLGATERLVQMGYPVLVGASRKRFLTALRPASDGN
HCCCHHEEEECCCCCCCCCCHHHHEEHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCC
PGTPESADDATAATSALAAAVGAWAVRVHKVAPTRAAVDVAHAMATGRGPDIDEQWRARR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]