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The map label for this gene is msrA [H]

Identifier: 68535175

GI number: 68535175

Start: 130494

End: 131222

Strand: Direct

Name: msrA [H]

Synonym: jk0110

Alternate gene names: 68535175

Gene position: 130494-131222 (Clockwise)

Preceding gene: 68535174

Following gene: 68535178

Centisome position: 5.3

GC content: 63.37

Gene sequence:

>729_bases
ATGACGAACTTCTTCGACCGCATTATGGCACTCAACAGCAAAGGACCGTACCGGGCCGAAAGAGTCGGGCCGGAGGATGC
ACTGAAGGGCGGACGGACGCCCGTACTGGAGAATCCGCAGCCGAACGTAGTTCTGGGAACGCCACTGACCGGCCTGGAGG
ATAGCTATTGGGCCGAGGCCGATGGGCTAGAGCAACCCGCGCAAATCGTTCTGGGGCTGGGCTGCTTCTGGGGTGTGGAG
CGCATGTTCTGGGGCGTGGACGGAGTGTGGGGAACCTCCGTAGGCTACGCCGGTGGCTACACCCCAAACCCCACCTACCG
CGAGGTCTGCACCGGGCGGACCGGCCATGCGGAGGTGGTGCGGGTTATCTTTGACGCCGCCGCGGTGAGCCTGGAACAAC
TGCTGCAGATCGCCTTTGAGAACCACGATCCTACGCAGGGGGACCGGCAGGGCAACGACGTGGGCACGCAATACCGTTCG
TGTGTGTACACGCAGGATGCTGAACAGTTGGGACGCGTGCGGCAGGCCATCGCAGGCTGGCAGCAGCGCTTTAGTGACGC
GGGCTTCGGGGAGATCACCACGGAAGTGGCCGAGCTGGCGGACATTGGCGACGGTCAGTACTACCTGGCCGAGGACGAGC
ACCAGCAGTATCTACACAAGAACCCCGGCGGGTATTGCAACCACGGTTCAAATGGCGTGAGTTGCCCCGTCGGGGTGCTG
GGGGACTAG

Upstream 100 bases:

>100_bases
CGCCGACGACTGCGTGGCGACCTCGGCGGTTCGCGCCTGGCTGCGCCGGGGCGCGCCGGGCCTGCGGGAACTGCGGCGTC
AATAAAAAAGAGGACAAGAT

Downstream 100 bases:

>100_bases
CGAGCCAGCAACTGTGGCTCTACTTGGAGAGGTTCTGGTTCGGAATGCGCCCCTCCGGAACGACCTTGCCGCCGTCCCAG
CGGAAGGTGACGTCTGAGTA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTNFFDRIMALNSKGPYRAERVGPEDALKGGRTPVLENPQPNVVLGTPLTGLEDSYWAEADGLEQPAQIVLGLGCFWGVE
RMFWGVDGVWGTSVGYAGGYTPNPTYREVCTGRTGHAEVVRVIFDAAAVSLEQLLQIAFENHDPTQGDRQGNDVGTQYRS
CVYTQDAEQLGRVRQAIAGWQQRFSDAGFGEITTEVAELADIGDGQYYLAEDEHQQYLHKNPGGYCNHGSNGVSCPVGVL
GD

Sequences:

>Translated_242_residues
MTNFFDRIMALNSKGPYRAERVGPEDALKGGRTPVLENPQPNVVLGTPLTGLEDSYWAEADGLEQPAQIVLGLGCFWGVE
RMFWGVDGVWGTSVGYAGGYTPNPTYREVCTGRTGHAEVVRVIFDAAAVSLEQLLQIAFENHDPTQGDRQGNDVGTQYRS
CVYTQDAEQLGRVRQAIAGWQQRFSDAGFGEITTEVAELADIGDGQYYLAEDEHQQYLHKNPGGYCNHGSNGVSCPVGVL
GD
>Mature_241_residues
TNFFDRIMALNSKGPYRAERVGPEDALKGGRTPVLENPQPNVVLGTPLTGLEDSYWAEADGLEQPAQIVLGLGCFWGVER
MFWGVDGVWGTSVGYAGGYTPNPTYREVCTGRTGHAEVVRVIFDAAAVSLEQLLQIAFENHDPTQGDRQGNDVGTQYRSC
VYTQDAEQLGRVRQAIAGWQQRFSDAGFGEITTEVAELADIGDGQYYLAEDEHQQYLHKNPGGYCNHGSNGVSCPVGVLG
D

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=171, Percent_Identity=57.3099415204678, Blast_Score=206, Evalue=1e-53,
Organism=Homo sapiens, GI208609995, Length=171, Percent_Identity=57.3099415204678, Blast_Score=204, Evalue=4e-53,
Organism=Homo sapiens, GI208609993, Length=128, Percent_Identity=54.6875, Blast_Score=140, Evalue=8e-34,
Organism=Escherichia coli, GI1790665, Length=210, Percent_Identity=47.6190476190476, Blast_Score=187, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=29.9319727891156, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320881, Length=180, Percent_Identity=33.8888888888889, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=31.7073170731707, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553131, Length=145, Percent_Identity=32.4137931034483, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664631, Length=164, Percent_Identity=30.4878048780488, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 26352; Mature: 26221

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFFDRIMALNSKGPYRAERVGPEDALKGGRTPVLENPQPNVVLGTPLTGLEDSYWAEA
CCHHHHHHHHHCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DGLEQPAQIVLGLGCFWGVERMFWGVDGVWGTSVGYAGGYTPNPTYREVCTGRTGHAEVV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHH
RVIFDAAAVSLEQLLQIAFENHDPTQGDRQGNDVGTQYRSCVYTQDAEQLGRVRQAIAGW
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QQRFSDAGFGEITTEVAELADIGDGQYYLAEDEHQQYLHKNPGGYCNHGSNGVSCPVGVL
HHHHCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GD
CC
>Mature Secondary Structure 
TNFFDRIMALNSKGPYRAERVGPEDALKGGRTPVLENPQPNVVLGTPLTGLEDSYWAEA
CHHHHHHHHHCCCCCCCHHHCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
DGLEQPAQIVLGLGCFWGVERMFWGVDGVWGTSVGYAGGYTPNPTYREVCTGRTGHAEVV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHH
RVIFDAAAVSLEQLLQIAFENHDPTQGDRQGNDVGTQYRSCVYTQDAEQLGRVRQAIAGW
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
QQRFSDAGFGEITTEVAELADIGDGQYYLAEDEHQQYLHKNPGGYCNHGSNGVSCPVGVL
HHHHCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
GD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]