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The map label for this gene is zwf [H]

Identifier: 66768298

GI number: 66768298

Start: 2389694

End: 2391124

Strand: Reverse

Name: zwf [H]

Synonym: XC_1977

Alternate gene names: 66768298

Gene position: 2391124-2389694 (Counterclockwise)

Preceding gene: 66768300

Following gene: 66768297

Centisome position: 46.44

GC content: 67.65

Gene sequence:

>1431_bases
ATGCACAACACCCTGATCCTGTTCGGCGCCACCGGCGATCTCGCCCAGCGCTATCTCTTTCCATCCCTGCTGCGCCTGTT
TGTCGACGGCCTGTTGCCGGAGGACTTCCGCATCCGTGCGTTGGCCCTGTCGCAGCACGACACCGACGCCTTCCGCGAGG
TACTGCGCCCGCGCCTGGCCCAGGCGCTGCCGATTGCCACCGCCGCGCAGATCGATGCGCTGCTGCAGCGCATCGACTAC
CGCTCGGCGGACCTGCGCAATGCCGAATCGGTGGCCGAGGCCGTGCGCGAACTGGCCAGCCGCCAGTGCGTAAGCTATCT
GGCGATTCCACCGGGCCTGTACATCAGTACCTGCCAGGGCCTGGCCCTGGGCGGCGCGCTGGCTGCACCGCACCGGTTGA
TGCTGGAAAAACCGATCGGCCACGATTCGGACAGCGCCCGCGAGATCCTGCAGTCGATCGGCGCACTGATCGACGAAGAC
CGCGTGTTCCGTCTCGACCACTACCTGGGCAAGGCCGCGGTGCAGAACCTGGTGGCGCTGCGCTTCGGCAACACCTTGCT
GGAAGCGGTGTGGAACCGGACCTACATCGAATCGGTACAGATCCTGGTGGCCGAGAGCGAAGGCGTGGACGGCCGCGATG
CCTACTACGCCCGCTCCGGCGCGCTGCGCGACATGGTGCAGAGCCATATCCTGCAGTTGCTGTGCCTGGTGGCCATGGAG
CCGCCGGCCTCGCTGGAAGCCGACCGCATCCGCGACGAGAAGGTCAAGGTGCTGCGCGCCTTGCGCCCGATGACCGCCGA
GCACGCCGCGCAAGACAGCGTGCGTGGCCGCTACACCGCCGGCAGCATCAACGGCGAGCCGGCGCAGGCCTACCACCCGC
CGGAAGGCAGCGATGTGGAAACCTTCGTCGCGGTCACCGCGCACATCGACAACTGGCGCTGGGCTGGCGTGCCGTTCCAC
CTGTGCACCGGCAAGCGCCTGGCTGAGCGCTCCACGCGCATCGTGGTCACGCTCAAGCCGGTGACGCATTGGTTGTTCGA
GCGTCCGGACCGCCAGAACGCGGTGCCCAACCGCCTGACCTTCCAGCTGCAGCCGCTGGAAAACATCGAGCTGGGCCTGA
TGAGCAGCCTGGCCGGCCCGGAATGGGGTGCGATCGAACTGCAGCCGCTGGAACTGGAGCTGTCCGTGCCCACCGGCCTG
CACCGCCGTATCGCGTATGAACGCTTGTTCGTGGATGCCTTCAACGGCAACCCGGCGCTGTTCGTGCGCGATGACGAGGT
CAAGGCCGCCTGGGCCTGGATCGACAGCGTCAGCGATGCCTGGTCGGACGCACAGCTGCCGCTGCAGCCGTATCCGGCCG
GTAGCTGGGGCCCCGAGACCGCCGCACCGTTCCTGCCCCCGGCCACCGACGCACAGGGAAACAACGCATGA

Upstream 100 bases:

>100_bases
CGCAAGTGTCGCCAGGAACAGACGTACCGACCGCCGGCATCACCGGCGCCTTCCCGCCAAGCCGCTGATAACGATGTCTC
CAGAATCTGAAACTCGGTCC

Downstream 100 bases:

>100_bases
CTGCTCCTTCCAAGCCGGTGCTGGTTGCCGACATCGGTGGCACCAACGCGCGCTTCGCGCTGGCCGACATCGATGCCTCG
GTACCGCTGCTGGACGACAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLAQALPIATAAQIDALLQRIDY
RSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDED
RVFRLDHYLGKAAVQNLVALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA

Sequences:

>Translated_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLAQALPIATAAQIDALLQRIDY
RSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDED
RVFRLDHYLGKAAVQNLVALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA
>Mature_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLAQALPIATAAQIDALLQRIDY
RSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDED
RVFRLDHYLGKAAVQNLVALRFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=476, Percent_Identity=33.8235294117647, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI108773793, Length=476, Percent_Identity=33.8235294117647, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI52145310, Length=472, Percent_Identity=28.6016949152542, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1788158, Length=464, Percent_Identity=40.301724137931, Blast_Score=348, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17538218, Length=477, Percent_Identity=33.5429769392034, Blast_Score=251, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6324088, Length=485, Percent_Identity=32.1649484536082, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=33.0543933054393, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=33.0543933054393, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=27.4633123689727, Blast_Score=155, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 52619; Mature: 52619

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
QALPIATAAQIDALLQRIDYRSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQG
HHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDEDRVFRLDHYLGKAAVQNLVAL
HHHCCHHHCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCHHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA
EEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLFVDGLLPEDFRIRALALSQHDTDAFREVLRPRLA
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
QALPIATAAQIDALLQRIDYRSADLRNAESVAEAVRELASRQCVSYLAIPPGLYISTCQG
HHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSAREILQSIGALIDEDRVFRLDHYLGKAAVQNLVAL
HHHCCHHHCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILVAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAQDSVRGRYTAGSINGEPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPLENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCHHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWAWIDSVSDAWSDAQLPLQPYPAGSWGPETAAPFLPPATDAQGNNA
EEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]