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The map label for this gene is guaB [H]

Identifier: 66768255

GI number: 66768255

Start: 2334054

End: 2335511

Strand: Direct

Name: guaB [H]

Synonym: XC_1934

Alternate gene names: 66768255

Gene position: 2334054-2335511 (Clockwise)

Preceding gene: 66768254

Following gene: 66768256

Centisome position: 45.33

GC content: 64.54

Gene sequence:

>1458_bases
ATGCTCCGCATCCAGGCTGAAGCTCTTACCTACGACGACGTCTCGCTCGTCCCCGCGCATTCCATTGTCCTGCCAAAGGA
CGTCAGCCTTGAGACTCGGCTGACACGCGACCTGCGCCTCAAACTGCCGATCTTGTCCGCGGCCATGGATACGGTGACCG
AACACCGCCTGGCGGTGGCGATGGCCCAGCTGGGCGGCATCGGCATCATCCACAAGAACCTGACCCCGGCGCAGCAGGCG
GGCGAGGTGGCCAAGGTCAAGAAGTTCGAGTCCGGCGTGATCACCGAGCCGTTTACGGTGAGCCCGGACACCACCATCGG
TGAAGTGATCGCGCTGACCCGCGCGCGCAACATCTCCGGCGTGCCGGTGGTGGATGGCAGCGAACTGGTTGGCATCGTGA
CCAGCCGCGACATGCGCTTCGAAAAGAAGCTCGACGATCCGGTCCGCCACATCATGACCAAGAAGGATCGCCTGATCACT
GTGCGCGAAGGCGCCAGCGATGAGGAAGTGCTCGAGCTGCTGCATCGCAACCGCATCGAAAAGATCCTGGTGGTCAACGA
CAGCTTCGAGCTGCGCGGGCTGATTACGGTCAAGGACATCCAGAAGAAGACCGACAACCCCAACGCCGCCAAGGACGGCG
CCAAGCGCTTGCTGGTCGGTGCGGCGGTGGGTGTGGGCGGCGATACCGAACAACGTATCGAACTGCTCGCTGCTGCGGGT
GTGGACGTGGTCATCGTCGATACCGCGCACGGCCATTCGCAAGGCGTGATCGACCGCGTGGCCTGGGTCAAGAAGACCTA
CCCGCACCTGCAGGTGATCGGCGGCAATATCGTCACTGGCGATGCAGCGCTGGCGCTGATGGATGCCGGCGCCGACGCGG
TCAAGGTCGGCGTGGGCCCGGGGTCGATCTGCACCACCCGTGTGGTGGCCGGTGTGGGCGTGCCGCAGATCACCGCGGTG
GATATGGTGGCCGAAGCACTGCAGGACCGCATCCCGCTGATTGCCGATGGCGGCATCCGTTACTCCGGCGATATCGGCAA
GGCGCTGGTGGCCGGCGCGTCCACAGTGATGGTCGGCGGCTTGCTGGCTGGTACCGAGGAAGCGCCTGGCGAAGTCGAGT
TGTTCCAGGGCCGCAGCTACAAGAGCTACCGCGGCATGGGCAGCCTGGGCGCGATGGAGAAGGGGTCCAAGGACCGCTAT
TTCCAGGACGCTTCCGACGCCGACAAGCTGGTGCCCGAAGGCATCGAAGGCCGCGTGCCGTATCGCGGCCCGGTGGGCGG
CATCATCCATCAGCTGATCGGTGGCCTGCGCGCAACCATGGGCTACGTTGGCTGCGCCACGGTCGAGGAAATGCGCACCA
AGCCGAAGTTCGTCAAGATCACCGGCGCCGGTCAACGCGAAAGCCATGTGCACGACGTGCAGATCACGAAAGAGCCGCCG
AACTATCGCGCGGGCTAA

Upstream 100 bases:

>100_bases
GTTGGTGTAGCGCAGCATTGCGGCGGCACTCAGCTGCCGCAGTGTCTTCGCGGCCGCTTTCAGGGTAAAATGTCGCGCTT
CCCCAAACTCGGGTCCGCCG

Downstream 100 bases:

>100_bases
TTCGAATGTGGAAGGCCTCGCTCGCCTATCTTGCGGTCATCTCGGCAATGACCGTGGTGGCGCTGGGATTGCTGGCGGTG
TCTTCCGTGTTGTATCGCTG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPAQQA
GEVAKVKKFESGVITEPFTVSPDTTIGEVIALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKILVVNDSFELRGLITVKDIQKKTDNPNAAKDGAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPHLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATVEEMRTKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG

Sequences:

>Translated_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPAQQA
GEVAKVKKFESGVITEPFTVSPDTTIGEVIALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKILVVNDSFELRGLITVKDIQKKTDNPNAAKDGAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPHLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATVEEMRTKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG
>Mature_485_residues
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVAMAQLGGIGIIHKNLTPAQQA
GEVAKVKKFESGVITEPFTVSPDTTIGEVIALTRARNISGVPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLIT
VREGASDEEVLELLHRNRIEKILVVNDSFELRGLITVKDIQKKTDNPNAAKDGAKRLLVGAAVGVGGDTEQRIELLAAAG
VDVVIVDTAHGHSQGVIDRVAWVKKTYPHLQVIGGNIVTGDAALALMDAGADAVKVGVGPGSICTTRVVAGVGVPQITAV
DMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGGLLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRY
FQDASDADKLVPEGIEGRVPYRGPVGGIIHQLIGGLRATMGYVGCATVEEMRTKPKFVKITGAGQRESHVHDVQITKEPP
NYRAG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=485, Percent_Identity=44.5360824742268, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=485, Percent_Identity=44.5360824742268, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=485, Percent_Identity=44.5360824742268, Blast_Score=364, Evalue=1e-100,
Organism=Homo sapiens, GI34328930, Length=485, Percent_Identity=44.5360824742268, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=43.6853002070393, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=44.5147679324894, Blast_Score=354, Evalue=8e-98,
Organism=Homo sapiens, GI217035148, Length=485, Percent_Identity=43.7113402061856, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI217035150, Length=485, Percent_Identity=41.2371134020619, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI156104880, Length=261, Percent_Identity=36.7816091954023, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=63.0390143737166, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1786293, Length=267, Percent_Identity=34.4569288389513, Blast_Score=149, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=499, Percent_Identity=40.0801603206413, Blast_Score=310, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI71994389, Length=421, Percent_Identity=42.5178147268409, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17560440, Length=255, Percent_Identity=33.7254901960784, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=40.2464065708419, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=39.9585921325052, Blast_Score=331, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.1656314699793, Blast_Score=318, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=39.9408284023669, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=36.8794326241135, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=41.7879417879418, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=41.7879417879418, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=42.5968109339408, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51581; Mature: 51581

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPAQQAGEVAKVKKFESGVITEPFTVSPDTTIGEVIALTRARNISG
HHHHCCEEEEECCCCCHHHCCCHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KILVVNDSFELRGLITVKDIQKKTDNPNAAKDGAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEECCCCCEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPHLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATVEEMRTKPKFVKITGAGQRESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCC
NYRAG
CCCCC
>Mature Secondary Structure
MLRIQAEALTYDDVSLVPAHSIVLPKDVSLETRLTRDLRLKLPILSAAMDTVTEHRLAVA
CEEEEEEEEEECCCEECCCCEEECCCCCCHHHHHCCCEEEECHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTPAQQAGEVAKVKKFESGVITEPFTVSPDTTIGEVIALTRARNISG
HHHHCCEEEEECCCCCHHHCCCHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
VPVVDGSELVGIVTSRDMRFEKKLDDPVRHIMTKKDRLITVREGASDEEVLELLHRNRIE
CEEECCCCEEEEEECCCCHHHHHCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCC
KILVVNDSFELRGLITVKDIQKKTDNPNAAKDGAKRLLVGAAVGVGGDTEQRIELLAAAG
EEEEECCCCCEEEEEEEHHHHHHCCCCCHHHHHHHHEEEEEEECCCCCHHHHHHHHHHCC
VDVVIVDTAHGHSQGVIDRVAWVKKTYPHLQVIGGNIVTGDAALALMDAGADAVKVGVGP
CCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEECCCCEEEEECCC
GSICTTRVVAGVGVPQITAVDMVAEALQDRIPLIADGGIRYSGDIGKALVAGASTVMVGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCCHHHHHHHCCHHHHHHH
LLAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEKGSKDRYFQDASDADKLVPEGIEGRVP
EEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCC
YRGPVGGIIHQLIGGLRATMGYVGCATVEEMRTKPKFVKITGAGQRESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCCC
NYRAG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA