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The map label for this gene is ccmA [H]

Identifier: 66768219

GI number: 66768219

Start: 2293468

End: 2294112

Strand: Reverse

Name: ccmA [H]

Synonym: XC_1898

Alternate gene names: 66768219

Gene position: 2294112-2293468 (Counterclockwise)

Preceding gene: 66768222

Following gene: 66768218

Centisome position: 44.56

GC content: 70.54

Gene sequence:

>645_bases
ATGATCGATCCGCTCCACACTGCGCCGCCGCTGCTGGCTGCGCGCGCGCTGGCCTTCAGCCGCAACGAGGAGCCGGTGTT
CGGCCCGCTGGACTTCCATGTCGATGCCGGCGAGGCCTTGCTGGTGCAAGGCGACAACGGCGCCGGCAAGACCACGCTGC
TGCGCGTGCTGGCCGGGCTGCTGCACGTGGAGCGCGGCGAGATCCTGATCGACGGCAAGACCGCTCGCCGTGGCGACCGC
AGCCGCTTCATGGCCTACCTCGGGCATCTGCCCGGCCTCAAGGCCGACCTCAGCACGCTGGAAAACCTGCATTTCCTGTG
CGGCCTGCACGGCCGGCGGGCCAAGCAGATGCCTGGCAGTGCACTGGCCATCGTGGGCCTGGCCGGCTACGAGGATGCGT
TGGTGCGGCAGCTCTCGGCCGGCCAGCGCAAGCGGCTGGCGCTGGCCCGGCTGTGGCTCTCGCCGGCCCCGCTGTGGTTG
CTGGACGAACCCTATGCCAACCTGGATCTGGAGGGCATCACCCTGGTCAACCGGATGATTTCCGCGCATCTGCGTGGCGG
TGGCGCGGCCCTGGTCACCACGCACGGCGCCTATGCCGCGCCGCCGGTGCGCACGCGCATGCTGACCCTGGAGGCCGCCG
CATGA

Upstream 100 bases:

>100_bases
CACACCGCATGCGCGGCCCCGGGCCGTACGCATCGCCGCTACAATGCGCGCCCTGTCCCGCCCTTCCCATGCCGTCCTGC
GACGGGAGCCCGCTGCGCCG

Downstream 100 bases:

>100_bases
GCGCGCATTCGCCGCAACCCTCGCTGTGGCAGGCCGGGCGGGCGCTGGTGCGCCGCGACCTGCAACTGCTGTGGCGCCGC
CGCAGCGATGCGCTGCAACC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIDPLHTAPPLLAARALAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGEILIDGKTARRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLEGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEAAA

Sequences:

>Translated_214_residues
MIDPLHTAPPLLAARALAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGEILIDGKTARRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLEGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEAAA
>Mature_214_residues
MIDPLHTAPPLLAARALAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGLLHVERGEILIDGKTARRGDR
SRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGSALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWL
LDEPYANLDLEGITLVNRMISAHLRGGGAALVTTHGAYAAPPVRTRMLTLEAAA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI105990541, Length=195, Percent_Identity=27.6923076923077, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI27881501, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30795238, Length=180, Percent_Identity=28.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI6005701, Length=182, Percent_Identity=29.6703296703297, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=202, Percent_Identity=42.0792079207921, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87081709, Length=148, Percent_Identity=34.4594594594595, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790467, Length=193, Percent_Identity=32.1243523316062, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI87082267, Length=190, Percent_Identity=30, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87081782, Length=157, Percent_Identity=34.3949044585987, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1786563, Length=149, Percent_Identity=32.8859060402685, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787029, Length=211, Percent_Identity=27.9620853080569, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1788761, Length=204, Percent_Identity=28.921568627451, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787370, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786872, Length=180, Percent_Identity=32.7777777777778, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790544, Length=210, Percent_Identity=29.5238095238095, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1789032, Length=146, Percent_Identity=30.8219178082192, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081834, Length=184, Percent_Identity=28.2608695652174, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786698, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786253, Length=190, Percent_Identity=32.6315789473684, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1787164, Length=210, Percent_Identity=34.2857142857143, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786703, Length=192, Percent_Identity=28.125, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787712, Length=147, Percent_Identity=34.6938775510204, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87081791, Length=209, Percent_Identity=30.1435406698565, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789873, Length=192, Percent_Identity=30.2083333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789586, Length=185, Percent_Identity=29.1891891891892, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787182, Length=204, Percent_Identity=27.4509803921569, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788225, Length=199, Percent_Identity=29.1457286432161, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=140, Percent_Identity=33.5714285714286, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983516, Length=140, Percent_Identity=33.5714285714286, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983510, Length=140, Percent_Identity=33.5714285714286, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=210, Percent_Identity=30, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559834, Length=190, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555318, Length=190, Percent_Identity=32.1052631578947, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325199, Length=185, Percent_Identity=30.8108108108108, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641342, Length=195, Percent_Identity=31.2820512820513, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI221512771, Length=198, Percent_Identity=29.7979797979798, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642252, Length=190, Percent_Identity=33.6842105263158, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859989, Length=190, Percent_Identity=33.6842105263158, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221500365, Length=198, Percent_Identity=28.7878787878788, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007184, Length=198, Percent_Identity=28.7878787878788, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22941; Mature: 22941

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPLHTAPPLLAARALAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGL
CCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHVERGEILIDGKTARRGDRSRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGS
HEECCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCC
ALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWLLDEPYANLDLEGITLVNRMI
EEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
SAHLRGGGAALVTTHGAYAAPPVRTRMLTLEAAA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MIDPLHTAPPLLAARALAFSRNEEPVFGPLDFHVDAGEALLVQGDNGAGKTTLLRVLAGL
CCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
LHVERGEILIDGKTARRGDRSRFMAYLGHLPGLKADLSTLENLHFLCGLHGRRAKQMPGS
HEECCCCEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCC
ALAIVGLAGYEDALVRQLSAGQRKRLALARLWLSPAPLWLLDEPYANLDLEGITLVNRMI
EEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
SAHLRGGGAALVTTHGAYAAPPVRTRMLTLEAAA
HHHHCCCCEEEEEECCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]