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The map label for this gene is pyrC [H]

Identifier: 66768179

GI number: 66768179

Start: 2254559

End: 2255908

Strand: Reverse

Name: pyrC [H]

Synonym: XC_1858

Alternate gene names: 66768179

Gene position: 2255908-2254559 (Counterclockwise)

Preceding gene: 66768180

Following gene: 66768178

Centisome position: 43.82

GC content: 65.04

Gene sequence:

>1350_bases
ATGAGCCGAACCGTCATCGTCAACGCCCGCCTGGTCAATGAAGGCAAGGAGTTCGACGCCGATCTCCTGATCGAAGGCGG
CCGCATCGCCCGCATCGACAGCCATATCGCACCGGCTGCCGGCGACACCGTGGTGGATGCGGCCGGCCGCTGGCTGCTGC
CCGGGATGATCGATGACCAGGTGCACTTCCGCGAGCCGGGCCTGACCCACAAGGGCGACATCGCCACCGAATCCGGTGCC
GCGGTGGCCGGTGGCCTGACCAGCTTCATGGACATGCCCAACACCAATCCGCCGACCCTGAACGCCGACGCGCTGCAGGC
CAAGTACGATGCGGCCGCCGGGCGCGCCTGGGCCAACTACGGCTTCTACATGGGCGCCAGCAACGACAACCTGGCCCACA
TCCAGTCGCTGGACCCCAAGACCGCACCCGGCATCAAGGTGTTCATGGGCGCCTCCACTGGCAACATGCTGGTGGACAAC
CCCGAGACGCTGGATGCGATCTTCCGCGACGCCCCCACGCCGATCATCACCCACTGCGAAGACACCCCCACCATCGATGC
CACGATGGCCGCCTACAAGGAAAAGTACGGCGACGCATTGACTGCCGAGATGCATCCGGACATCCGCTCGCGCGAAGCCT
GCCTGAAGTCCTCGCAGCTGGCGGTGTCGCTGGCGCGCAAGCACAACACCCGCCTGCACGTGCTGCACATCTCCACCGCC
GATGAATTGATGCTGTTCGAAGCCGGCCCGCTGGTGGATGCCGATGGCAAGGTGCGCAAGCGCATCACCGCCGAGACCTG
CATCCATTTCCTGCGCTTTGACCGCAGCGATTACGCGCGCCTGGGCAACCTGATCAAATGCAATCCCGCGATCAAGGATC
CCGAGGACCGCCTGGCATTGATCGAGGCCTTGGCCGAAGACGTCATCGACGTGCTCGCCACCGATCATGCCCCGCATACC
TGGGACGAAAAGCAGAAGCCGTATGCGCAGGCACCCTCGGGCTTGCCGCTGGTGCAATACGCGCTGGTCGCCGCGCTGGA
GCTCGTGCATGAAGGCAAGCTGCCGATCACCCGCGTCGTGCAGAAGTTTGCGCATGCGCCGGCGCAGTTGTTCGACGTGG
AGCAACGCGGCTTCCTGCGCGAAGGCTACTTCGCCGACCTGGTGCTGATCGACAACAGGCCGTTCACCGTCAAGCGCGAA
CAGGTGTTGTCCAAGTGCGGCTGGTCGCCGTTCGAAGGCACCACCTTCCGCTCACGCATCGCTGCAACCTGGGTCAACGG
CCAGCAGGTGTGGGATGGCGAACAGCTGGTGGGCAGTGCCGCCGGCCAGCGCCTGACCTTCGACCGCTGA

Upstream 100 bases:

>100_bases
GCTTGGGCCGCTGCCATCCGTTCCATCCGGGCGGGTTCGACCCCGTTCCCGATGCGCCCACATCTTCCCCCTCTTCCTGC
CGCTGCAAAGGACCCCATCC

Downstream 100 bases:

>100_bases
TGCGTGCACTGCTGATGGGCGCGGCGCTTGCGCTGGCGCCGTGCACATTGCTCACGGTGCCGGTGTCTGCGCAGGAGCCC
GCCGCTGCAGACGGGCGCGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
DELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLALIEALAEDVIDVLATDHAPHT
WDEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVVQKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKRE
QVLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR

Sequences:

>Translated_449_residues
MSRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQVHFREPGLTHKGDIATESGA
AVAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDN
PETLDAIFRDAPTPIITHCEDTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
DELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLALIEALAEDVIDVLATDHAPHT
WDEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVVQKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKRE
QVLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR
>Mature_448_residues
SRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQVHFREPGLTHKGDIATESGAA
VAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANYGFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNP
ETLDAIFRDAPTPIITHCEDTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTAD
ELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLALIEALAEDVIDVLATDHAPHTW
DEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVVQKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKREQ
VLSKCGWSPFEGTTFRSRIAATWVNGQQVWDGEQLVGSAAGQRLTFDR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=396, Percent_Identity=28.7878787878788, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI19923821, Length=414, Percent_Identity=22.463768115942, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4503375, Length=456, Percent_Identity=23.4649122807018, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786722, Length=452, Percent_Identity=26.9911504424779, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=25.4347826086956, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193204318, Length=385, Percent_Identity=29.8701298701299, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71989490, Length=458, Percent_Identity=25.3275109170306, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539558, Length=467, Percent_Identity=25.0535331905782, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=459, Percent_Identity=25.7080610021786, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=30.1507537688442, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI18859883, Length=467, Percent_Identity=25.6959314775161, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221377917, Length=467, Percent_Identity=26.338329764454, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 49147; Mature: 49016

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQ
CCCEEEEEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLAL
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHHHHH
IEALAEDVIDVLATDHAPHTWDEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVV
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGQQVWDGEQLVGSAAGQRLTFDR
EEEEECCCEECCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRTVIVNARLVNEGKEFDADLLIEGGRIARIDSHIAPAAGDTVVDAAGRWLLPGMIDDQ
CCEEEEEEEEECCCCCCCCEEEEECCEEEEECCCCCCCCCCHHHHCCCCEECCCCCCCC
VHFREPGLTHKGDIATESGAAVAGGLTSFMDMPNTNPPTLNADALQAKYDAAAGRAWANY
EEECCCCCCCCCCCCCCCCCCHHCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHCC
GFYMGASNDNLAHIQSLDPKTAPGIKVFMGASTGNMLVDNPETLDAIFRDAPTPIITHCE
CEEEECCCCCCEEEECCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEECCC
DTPTIDATMAAYKEKYGDALTAEMHPDIRSREACLKSSQLAVSLARKHNTRLHVLHISTA
CCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
DELMLFEAGPLVDADGKVRKRITAETCIHFLRFDRSDYARLGNLIKCNPAIKDPEDRLAL
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCEEEECCCCCCHHHHHHH
IEALAEDVIDVLATDHAPHTWDEKQKPYAQAPSGLPLVQYALVAALELVHEGKLPITRVV
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
QKFAHAPAQLFDVEQRGFLREGYFADLVLIDNRPFTVKREQVLSKCGWSPFEGTTFRSRI
HHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEHHHHHHHCCCCCCCCCHHHHHH
AATWVNGQQVWDGEQLVGSAAGQRLTFDR
EEEEECCCEECCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 7929010 [H]