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The map label for this gene is apt [H]

Identifier: 66768153

GI number: 66768153

Start: 2225408

End: 2225968

Strand: Direct

Name: apt [H]

Synonym: XC_1832

Alternate gene names: 66768153

Gene position: 2225408-2225968 (Clockwise)

Preceding gene: 66768152

Following gene: 66768155

Centisome position: 43.22

GC content: 66.84

Gene sequence:

>561_bases
ATGAACGACTGCAGCCGCTGCGCCGGTTCCACCTCTTCCGGACCGGCCCACTGGTCGGGCCGGATCCGCGACATCGCCGA
TTTTCCCAAGCCGGGTATCGTGTTCAAGGACATCACACCGCTGCTGTCCGATGGCCCGGATTTCGCTTCTGCGCTGGATG
AAATGGCGCAGCCCTGGCGCACCACGCCGCTGGATGCGGTGCTGGGCATCGAGGCGCGGGGCTTCATTCTGGGCGCGGCG
TTGGCGCGCGAGCTGCGCACTGGCTTCGTGCCGGTGCGCAAACCGGGCAAATTACCCGGGCGCACGTTGATCCAGGAATA
CGCGCTGGAATACGGCACCGATCGCATCGAGATGCATGAGGATGCGCTGCCGCGTGGTGCACGGGTCTTGATTGTCGACG
ACGTGCTCGCCACCGGCGGCACCCTGCGTGCGGCCTTGGGCCTGGCCGCGCAGCTGGAGCTGGAAATCGTCGGCGCGGCG
GTGCTGGTCGAGCTGCTGGCCCTGCAGGGCCGCAGCAAATGGCTCAACGACGTGCCGTTGCTGGCGACGCTGAGCTACTG
A

Upstream 100 bases:

>100_bases
GTCCTGCAGTTCCTGACGCGCTCATGTCGGCAGCGGTCGTCGGCGCCGCACAGTCGGCCCGCTCGCCTAGAATAGAGCGC
TCCCACTGGCCACGACCGCC

Downstream 100 bases:

>100_bases
GCAAGGGATCGCTGTACCTGTGCAGCGGCCAAGCCGCTGCGCCGTCGAGCCCACCTGCGTGGGCTCCCTGATTCGGCTAG
ACGCGCTGCCTAGAGCTTGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MNDCSRCAGSTSSGPAHWSGRIRDIADFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEIVGAA
VLVELLALQGRSKWLNDVPLLATLSY

Sequences:

>Translated_186_residues
MNDCSRCAGSTSSGPAHWSGRIRDIADFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEIVGAA
VLVELLALQGRSKWLNDVPLLATLSY
>Mature_186_residues
MNDCSRCAGSTSSGPAHWSGRIRDIADFPKPGIVFKDITPLLSDGPDFASALDEMAQPWRTTPLDAVLGIEARGFILGAA
LARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHEDALPRGARVLIVDDVLATGGTLRAALGLAAQLELEIVGAA
VLVELLALQGRSKWLNDVPLLATLSY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=46.7455621301775, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI71773201, Length=122, Percent_Identity=48.3606557377049, Blast_Score=115, Evalue=3e-26,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=44.5121951219512, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=169, Percent_Identity=47.3372781065089, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=180, Percent_Identity=36.6666666666667, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=168, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=37.1069182389937, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19931; Mature: 19931

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDCSRCAGSTSSGPAHWSGRIRDIADFPKPGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEIVGAAVLVELLALQGRSKWLNDVPL
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
LATLSY
EEEECC
>Mature Secondary Structure
MNDCSRCAGSTSSGPAHWSGRIRDIADFPKPGIVFKDITPLLSDGPDFASALDEMAQPWR
CCCHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEEHHHCCHHHCCCCHHHHHHHHHHCCCC
TTPLDAVLGIEARGFILGAALARELRTGFVPVRKPGKLPGRTLIQEYALEYGTDRIEMHE
CCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DALPRGARVLIVDDVLATGGTLRAALGLAAQLELEIVGAAVLVELLALQGRSKWLNDVPL
CCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCC
LATLSY
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]