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The map label for this gene is hsrA [H]

Identifier: 66768075

GI number: 66768075

Start: 2127183

End: 2128613

Strand: Reverse

Name: hsrA [H]

Synonym: XC_1754

Alternate gene names: 66768075

Gene position: 2128613-2127183 (Counterclockwise)

Preceding gene: 66768076

Following gene: 66768073

Centisome position: 41.34

GC content: 67.37

Gene sequence:

>1431_bases
ATGTCCTCCAGCGTGTCCGAGGCCGGCGCGGCGCCGGCGCCGCGTTATCCCGATTACCGCATCATCTCGCTGATCCTGGC
CTGCGCCATTTTCATGGAGCAGATGGATGCGACCGTGCTGGCGACGGCACTGCCGACCCTGGCGCGCGATTTCGGCGTGG
CCGCGCCGGCGATGAGCATCGCCATGACCAGCTACCTGCTGGCGCTGGCGGTGCTGATCCCGGCCAGCGGCGCGATCGCT
GACCGCTTCGGGCTGCGTCGCGTGTTCAGCGCCTCCATCTGGGTATTCATTGGCGGCTCCATCCTGTGCTCGCTGGCCGA
CAGCCTGCCGACCATGGTGGCCGCGCGGGTGCTGCAGGGCGCCGGCGGCGCGATGATGGCCCCGCTCGGGCGGCTGATCC
TACTGCGCACCGTGGAGCGCCGCCACCTGGTGTCCGCAATGGCCTGGACGCTGGTGCCGGCCTTCATCGGCCCGATGCTT
GGGCCGCCGCTGGGCGGGTTCTTCGTGTCCTACCTGGACTGGCGCTGGATCTTCTACATCAACGTGCCAATCGGCATCAC
CGGCTTTTTGCTGGTGCGGCGCTTCATTCCGGACATTCCCAGCGAATCTGCACCCGCGCGCTTTGATCTGCGCGGCTTCG
TGCTGTGCGGCACCGCCCTGGGCTGCCTGCTGTTCGGGCTGGAAATGGTCAGCCAGGAAGATGGCATCCCGCGCGCCAGC
TGGCTGCTGGCCATCGGTGGTGCCACGGCGCTGGGCTATCTGTGGCATGCGCGCCAGCATCCGGCACCGTTGCTGGATCT
GAGCCTGCTGCGGATCGACTCGTTCCGGCTGTCGGTGATCGGTGGCGCGCTGATGCGCATTACCCAGGGCGCGCATCCGT
TCCTGCTGCCGCTGCTGTTCCAGATCAGCTTCGGCTTCAGCGCCGCGCGCAGCGGGCGGCTGATCCTGGCCACCGCGCTG
GGCGCGCTGCTGATGCGCAGCATCACCCCGCAATTGCTGCGCCGCTTCGGCTACCGCAACAGCCTGATCGGCAACGGCGT
ACTGGCCAGCCTGGGCTACATGGTGTGCGCGCTGTTCAGGCCAGACTGGCCGCCGGCGCTGATGTTCGGTTTGCTGCTGT
GCTGCGGGGCGTTCATGTCGTTCCAGTTTGCCGCCTACAACACCATCGCCTACGAAAACGTGCCGGCCGCGCGCATGGGC
CGCGCCAGCAGCCTGTACACCACGCTGCAGCAATTGATGCTGTCGGTCGGTGTGTGTGCCGGCGCGATGATCCTCAAGCT
GGCGATGCTGGCGGGCGATCACCCGCAGCCGCAGCAACGCGATTTTTCGCTGGCGTTCTGCGTGGTCAGCCTGATCTCGC
TCAGCGCCACGTGGTGGCACGTGCGCTTCGACAAGCATGCCGGGCAGGAAATGAGCGGGCATCGCGCCTGA

Upstream 100 bases:

>100_bases
AGGCGGACAATGCCCATGTTGCGCCGCACAACACCGTGCGACGCGGGCCGCTCCAGCCGTCGCACCGTGCTGTTGCAGCG
GCCCCGCAACCGAGACTCCG

Downstream 100 bases:

>100_bases
GCCTGCGTCGCCGTGGCGACGCACTGCACTTGGCTGAGCGCGCGCCTGTCATCGCGTGATGGCTGATCAGGCGCGCGACG
CTGCGGTGGTTGCGCGCCTG

Product: drug resistance translocase

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSSSVSEAGAAPAPRYPDYRIISLILACAIFMEQMDATVLATALPTLARDFGVAAPAMSIAMTSYLLALAVLIPASGAIA
DRFGLRRVFSASIWVFIGGSILCSLADSLPTMVAARVLQGAGGAMMAPLGRLILLRTVERRHLVSAMAWTLVPAFIGPML
GPPLGGFFVSYLDWRWIFYINVPIGITGFLLVRRFIPDIPSESAPARFDLRGFVLCGTALGCLLFGLEMVSQEDGIPRAS
WLLAIGGATALGYLWHARQHPAPLLDLSLLRIDSFRLSVIGGALMRITQGAHPFLLPLLFQISFGFSAARSGRLILATAL
GALLMRSITPQLLRRFGYRNSLIGNGVLASLGYMVCALFRPDWPPALMFGLLLCCGAFMSFQFAAYNTIAYENVPAARMG
RASSLYTTLQQLMLSVGVCAGAMILKLAMLAGDHPQPQQRDFSLAFCVVSLISLSATWWHVRFDKHAGQEMSGHRA

Sequences:

>Translated_476_residues
MSSSVSEAGAAPAPRYPDYRIISLILACAIFMEQMDATVLATALPTLARDFGVAAPAMSIAMTSYLLALAVLIPASGAIA
DRFGLRRVFSASIWVFIGGSILCSLADSLPTMVAARVLQGAGGAMMAPLGRLILLRTVERRHLVSAMAWTLVPAFIGPML
GPPLGGFFVSYLDWRWIFYINVPIGITGFLLVRRFIPDIPSESAPARFDLRGFVLCGTALGCLLFGLEMVSQEDGIPRAS
WLLAIGGATALGYLWHARQHPAPLLDLSLLRIDSFRLSVIGGALMRITQGAHPFLLPLLFQISFGFSAARSGRLILATAL
GALLMRSITPQLLRRFGYRNSLIGNGVLASLGYMVCALFRPDWPPALMFGLLLCCGAFMSFQFAAYNTIAYENVPAARMG
RASSLYTTLQQLMLSVGVCAGAMILKLAMLAGDHPQPQQRDFSLAFCVVSLISLSATWWHVRFDKHAGQEMSGHRA
>Mature_475_residues
SSSVSEAGAAPAPRYPDYRIISLILACAIFMEQMDATVLATALPTLARDFGVAAPAMSIAMTSYLLALAVLIPASGAIAD
RFGLRRVFSASIWVFIGGSILCSLADSLPTMVAARVLQGAGGAMMAPLGRLILLRTVERRHLVSAMAWTLVPAFIGPMLG
PPLGGFFVSYLDWRWIFYINVPIGITGFLLVRRFIPDIPSESAPARFDLRGFVLCGTALGCLLFGLEMVSQEDGIPRASW
LLAIGGATALGYLWHARQHPAPLLDLSLLRIDSFRLSVIGGALMRITQGAHPFLLPLLFQISFGFSAARSGRLILATALG
ALLMRSITPQLLRRFGYRNSLIGNGVLASLGYMVCALFRPDWPPALMFGLLLCCGAFMSFQFAAYNTIAYENVPAARMGR
ASSLYTTLQQLMLSVGVCAGAMILKLAMLAGDHPQPQQRDFSLAFCVVSLISLSATWWHVRFDKHAGQEMSGHRA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=451, Percent_Identity=36.5853658536585, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1788392, Length=408, Percent_Identity=36.0294117647059, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI87081983, Length=420, Percent_Identity=28.8095238095238, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788710, Length=406, Percent_Identity=28.3251231527094, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1789042, Length=405, Percent_Identity=26.9135802469136, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6325455, Length=163, Percent_Identity=31.2883435582822, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=153, Percent_Identity=31.3725490196078, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=250, Percent_Identity=27.2, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51367; Mature: 51235

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSVSEAGAAPAPRYPDYRIISLILACAIFMEQMDATVLATALPTLARDFGVAAPAMSI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AMTSYLLALAVLIPASGAIADRFGLRRVFSASIWVFIGGSILCSLADSLPTMVAARVLQG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
AGGAMMAPLGRLILLRTVERRHLVSAMAWTLVPAFIGPMLGPPLGGFFVSYLDWRWIFYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEE
NVPIGITGFLLVRRFIPDIPSESAPARFDLRGFVLCGTALGCLLFGLEMVSQEDGIPRAS
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WLLAIGGATALGYLWHARQHPAPLLDLSLLRIDSFRLSVIGGALMRITQGAHPFLLPLLF
HHEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QISFGFSAARSGRLILATALGALLMRSITPQLLRRFGYRNSLIGNGVLASLGYMVCALFR
HHHCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
PDWPPALMFGLLLCCGAFMSFQFAAYNTIAYENVPAARMGRASSLYTTLQQLMLSVGVCA
CCCCHHHHHHHHHHHHHHHHHHHHHHHEHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
GAMILKLAMLAGDHPQPQQRDFSLAFCVVSLISLSATWWHVRFDKHAGQEMSGHRA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SSSVSEAGAAPAPRYPDYRIISLILACAIFMEQMDATVLATALPTLARDFGVAAPAMSI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AMTSYLLALAVLIPASGAIADRFGLRRVFSASIWVFIGGSILCSLADSLPTMVAARVLQG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
AGGAMMAPLGRLILLRTVERRHLVSAMAWTLVPAFIGPMLGPPLGGFFVSYLDWRWIFYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEE
NVPIGITGFLLVRRFIPDIPSESAPARFDLRGFVLCGTALGCLLFGLEMVSQEDGIPRAS
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
WLLAIGGATALGYLWHARQHPAPLLDLSLLRIDSFRLSVIGGALMRITQGAHPFLLPLLF
HHEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QISFGFSAARSGRLILATALGALLMRSITPQLLRRFGYRNSLIGNGVLASLGYMVCALFR
HHHCCCHHHCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
PDWPPALMFGLLLCCGAFMSFQFAAYNTIAYENVPAARMGRASSLYTTLQQLMLSVGVCA
CCCCHHHHHHHHHHHHHHHHHHHHHHHEHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
GAMILKLAMLAGDHPQPQQRDFSLAFCVVSLISLSATWWHVRFDKHAGQEMSGHRA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]