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The map label for this gene is fruA

Identifier: 66768065

GI number: 66768065

Start: 2107259

End: 2109001

Strand: Reverse

Name: fruA

Synonym: XC_1742

Alternate gene names: 66768065

Gene position: 2109001-2107259 (Counterclockwise)

Preceding gene: 66768066

Following gene: 66768064

Centisome position: 40.96

GC content: 69.42

Gene sequence:

>1743_bases
ATGTCCTCTTCCATCGTGGTCATCGCCGCCGGCGAACGCAGTACCGAAGCCGTTCTGGCGGCCGAAGCGCTGCGCCGCGC
GGCCACCGCCGCCGGGCGCAGCGTGACGATCGAAATCCGCAGCGACCAGGGCGTGCTCGGCGCACTGCCGACCGAGCTGA
CCAACGGCGCCGCGCACGTCCTGATCGTCGGCGATGCCGATGCCGACACCGCGCGCTTCGGCGACGCGCAACTGCTGCAT
CTGAGCCTGGGCGCGGTACTGGACGACCCGGCCGCCGCCGTCAGCCAGCTCGCTGCCACCACCGCACCAGCCAGTACATC
GGCAACGACCGACGCATCCGGCGCAGGCGGCAAGCGCATCGTTGCGATCACCTCCTGCCCCACCGGCATCGCGCACACTT
TCATGGCCGCCGAAGGCCTGCAGCAGGCCGCAAAGAAGCTCGGCTACCAGATGCGCGTGGAAACGCAGGGGTCGGTGGGC
GCGCAGGACGCATTGACCGACGAGGAAATCCGCGCGGCCGACGTGGTCATCATCGCTGCCGACCGCGAAGTGGACCTGGC
CCGTTTCGGTGGCAAGCGACTGTTCAAGAGCGGCACCAAGCCGGCGATCAACGATGGCCCGGCGCTCATCCAGAAAGCCC
TGGCCGAGGCCGGCGTGCACGGTGGCGCAGCTCCGGTTGCGGGCGCCAACGCCACATCGGACGCCAAGGGCAATGCGCGC
ACCGGCGCCTACAAGCACCTGATGACCGGTGTGTCGTTCATGCTGCCCTTCGTCACCGCTGGCGGCCTGTTGATCGCGCT
GGCCTTCGCGCTCGGCGGCATCTATGCCGGCGACGACGCGCACCAGGGCACGCTGGCCTGGTCGCTGTTCCAGATCGGCG
CCAAGGCCGGCTTCACCTTGATGGTGCCCGCGCTGGCCGGTTACATCGCCTATTCCATCGCCGACCGCCCCGGCATCGCG
CCGGGCATGATCGGCGGGCTGGTCGCGGCCAATCTCAATGCCGGTTTCCTCGGCGGCATCATTGCCGGCTTCATCGCCGG
CTACGGCGTGGCCGCGCTCAACCGCTACATCAAGCTGCCGCGCAACCTGGAAGGGCTCAAGCCGGTGCTGATCCTGCCGG
TGCTGGGCACACTGCTGGTCGGCCTGGCGATGATGTATGTGTTCGGCCAACCGGTGGCCGACCTGCTGGCCTGGCTCACC
GCCTGGCTGCGCGGCATGCAGGGCAGCAGCGCGCTGCTGCTGGGCCTGTTGCTCGGCGGCATGATGGCCTTCGACATGGG
CGGGCCGGTCAACAAGGCCGCCTACGCGTTCTCCACCGGCCTGATCGCCAGCCAGGTCTATACCCCGATGGCTGCGGCCA
TGGTGGCCGGCATGACCCCGCCGCTGGGCATCGCGCTGGCCACCTGGGTGTTCCGCAACCGCTTCACCGTCGAAGAACGC
GGCTCGGCCACCGCTGCCGGCGTGCTCGGGCTGGCCTTCGTCACCGAAGGCGCCATCCCGTATGCCGCCCGCGACCCGTT
GCGCACCATCCCGGCGCTGGTGATCGGCTCGGCCGTGGCCGGCGCGATCTCGATGACCGCCGGTGCCGAACTGAAGGCGC
CGCATGGCGGCATCTTCGTGCTGCTGATCCCCAATGCCGTGACCCACCTGCTCAATTACGTGCTGGCCCTGGTGGTCGGC
GTGGTGGTCACCGCGGTGGCGCTGCGCCTGCTCAAGAAGCCGGTGGCCGACGTGATCGCCTGA

Upstream 100 bases:

>100_bases
GCACCGCCTTGCTGCGCTGCTATCTGGCAGCCGCGCGCCTAGCCCTTCGAATCCCCCCCGCCGGCTGCGCCGGCGACCGC
AATACAGCAGGAGTTTTGCC

Downstream 100 bases:

>100_bases
CGTTCGGCTGCCCCGCCCCGACCGATTCCACACCGCGCATCCGGCGCATCTGATCGCTGATCTGCGTCACCCCTGACTGG
TTTCACCGCTGCGCTGCGCA

Product: PTS system fructose-specific II BC component

Products: NA

Alternate protein names: EIIBC-Fru; EII-Fru; Fructose-specific phosphotransferase enzyme IIB component; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRSVTIEIRSDQGVLGALPTELTNGAAHVLIVGDADADTARFGDAQLLH
LSLGAVLDDPAAAVSQLAATTAPASTSATTDASGAGGKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVG
AQDALTDEEIRAADVVIIAADREVDLARFGGKRLFKSGTKPAINDGPALIQKALAEAGVHGGAAPVAGANATSDAKGNAR
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIA
PGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYIKLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLT
AWLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTVEER
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALVVG
VVVTAVALRLLKKPVADVIA

Sequences:

>Translated_580_residues
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRSVTIEIRSDQGVLGALPTELTNGAAHVLIVGDADADTARFGDAQLLH
LSLGAVLDDPAAAVSQLAATTAPASTSATTDASGAGGKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVG
AQDALTDEEIRAADVVIIAADREVDLARFGGKRLFKSGTKPAINDGPALIQKALAEAGVHGGAAPVAGANATSDAKGNAR
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIA
PGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYIKLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLT
AWLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTVEER
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALVVG
VVVTAVALRLLKKPVADVIA
>Mature_579_residues
SSSIVVIAAGERSTEAVLAAEALRRAATAAGRSVTIEIRSDQGVLGALPTELTNGAAHVLIVGDADADTARFGDAQLLHL
SLGAVLDDPAAAVSQLAATTAPASTSATTDASGAGGKRIVAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGA
QDALTDEEIRAADVVIIAADREVDLARFGGKRLFKSGTKPAINDGPALIQKALAEAGVHGGAAPVAGANATSDAKGNART
GAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTLMVPALAGYIAYSIADRPGIAP
GMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYIKLPRNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTA
WLRGMQGSSALLLGLLLGGMMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTVEERG
SATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFVLLIPNAVTHLLNYVLALVVGV
VVTAVALRLLKKPVADVIA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain

Homologues:

Organism=Escherichia coli, GI1788492, Length=466, Percent_Identity=53.862660944206, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1786951, Length=487, Percent_Identity=38.8090349075975, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87082348, Length=474, Percent_Identity=36.0759493670886, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1790386, Length=297, Percent_Identity=47.8114478114478, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1788729, Length=378, Percent_Identity=27.2486772486773, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790387, Length=95, Percent_Identity=42.1052631578947, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788730, Length=97, Percent_Identity=37.1134020618557, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=43.0769230769231, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTFBC_XANCP (P23355)

Other databases:

- EMBL:   M69242
- EMBL:   AE008922
- PIR:   B40944
- RefSeq:   NP_637726.1
- ProteinModelPortal:   P23355
- SMR:   P23355
- GeneID:   998895
- GenomeReviews:   AE008922_GR
- KEGG:   xcc:XCC2372
- HOGENOM:   HBG704192
- OMA:   ARRKFAQ
- ProtClustDB:   CLSK813154
- BioCyc:   XCAM190485:XCC2372-MONOMER
- BRENDA:   2.7.1.69
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327
- TIGRFAMs:   TIGR00829
- TIGRFAMs:   TIGR01427

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB

EC number: =2.7.1.69

Molecular weight: Translated: 58648; Mature: 58517

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS51099 PTS_EIIB_TYPE_2; PS51104 PTS_EIIC_TYPE_2

Important sites: ACT_SITE 126-126

Signals:

None

Transmembrane regions:

HASH(0x147df650)-; HASH(0x15a546c4)-; HASH(0x14e53214)-; HASH(0x15a1e83c)-; HASH(0x15a86670)-; HASH(0x138f8870)-; HASH(0x158ad8d8)-; HASH(0x154deef4)-; HASH(0x15a83b94)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSIVVIAAGERSTEAVLAAEALRRAATAAGRSVTIEIRSDQGVLGALPTELTNGAAHV
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCHHHCCCCEEE
LIVGDADADTARFGDAQLLHLSLGAVLDDPAAAVSQLAATTAPASTSATTDASGAGGKRI
EEEECCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
VAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGAQDALTDEEIRAADVVIIAA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCEEEEEEEEC
DREVDLARFGGKRLFKSGTKPAINDGPALIQKALAEAGVHGGAAPVAGANATSDAKGNAR
CCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCEE
MVPALAGYIAYSIADRPGIAPGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYIKLP
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTAWLRGMQGSSALLLGLLLGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTVEER
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHC
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFV
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEE
LLIPNAVTHLLNYVLALVVGVVVTAVALRLLKKPVADVIA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SSSIVVIAAGERSTEAVLAAEALRRAATAAGRSVTIEIRSDQGVLGALPTELTNGAAHV
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCHHHCCCCEEE
LIVGDADADTARFGDAQLLHLSLGAVLDDPAAAVSQLAATTAPASTSATTDASGAGGKRI
EEEECCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
VAITSCPTGIAHTFMAAEGLQQAAKKLGYQMRVETQGSVGAQDALTDEEIRAADVVIIAA
EEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHCEEEEEEEEC
DREVDLARFGGKRLFKSGTKPAINDGPALIQKALAEAGVHGGAAPVAGANATSDAKGNAR
CCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TGAYKHLMTGVSFMLPFVTAGGLLIALAFALGGIYAGDDAHQGTLAWSLFQIGAKAGFTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCEE
MVPALAGYIAYSIADRPGIAPGMIGGLVAANLNAGFLGGIIAGFIAGYGVAALNRYIKLP
EHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
RNLEGLKPVLILPVLGTLLVGLAMMYVFGQPVADLLAWLTAWLRGMQGSSALLLGLLLGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMAFDMGGPVNKAAYAFSTGLIASQVYTPMAAAMVAGMTPPLGIALATWVFRNRFTVEER
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHC
GSATAAGVLGLAFVTEGAIPYAARDPLRTIPALVIGSAVAGAISMTAGAELKAPHGGIFV
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEE
LLIPNAVTHLLNYVLALVVGVVVTAVALRLLKKPVADVIA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217; 1650911