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The map label for this gene is fruK

Identifier: 66768066

GI number: 66768066

Start: 2109155

End: 2110111

Strand: Reverse

Name: fruK

Synonym: XC_1743

Alternate gene names: 66768066

Gene position: 2110111-2109155 (Counterclockwise)

Preceding gene: 66768067

Following gene: 66768065

Centisome position: 40.98

GC content: 71.37

Gene sequence:

>957_bases
ATGAGCCTGCAGGCCATCACCGTCACGCTGAATCCGGCGATCGACCAGACCATCCAGCTCGATCGCCTGCAACCTGGCGC
CGTGCACCGCGCCAGCAGCGTGCGCAACGATGCCGGCGGCAAGGGCATCAACGTGGCCGCCTGTCTGGCCGACTGGGGCA
GCCAGGTCGCCGCGCTCGGCGTGCTTGGCGTCGGTAACGCAGGGGTGTTCGAAGCGCTGTTTCGCGAGCGCGGCATTACC
GATCACTGCCACCGCGTGGCCGGCGACACCCGCACCAACCTCAAGCTGGTCGAAGCGCAGGTCAACGAGACCACCGACAT
CAATCTGCCCGGGCTGCAGCTGGGCCAGGCGCATCTGCAAGGCGTGGCCGACCATCTGGCCCCGCTGCTGCGCGCCGGCT
TGCCGGTGGTGCTCTCCGGCAGCCTGCCGGCCGGCCTGCCCGAGGACAGCTGGGCGCAGCTGCAGGCGCAGGCCAGCGCG
GCGGGCGCACGCGTCCTGCTCGACACCAGCGGTGCGCCGCTGGTGGCCGCACTCGCTGCCGCTCCCGTCGCAATGCCGTA
TGCAGTGAAGCCGAACCGCCACGAACTGGAAGCCTGGACCGGCCACCCGCTCGGCGACCACGCCGCACTCACCGCCGCCG
CGCATGCGCTGATCGCCCGCGGCATCCAGTTGGTGGTGATTTCCATGGGCACCGAGGGCGCGCTGTTCGTGCAGCGCGAC
CAACAGCTCATTGCGCGCCCGCCACGGCTGGCGCAAGGCAGCAGCGTGGGCGCCGGCGATGCCATGGTGGCCGGCCTGGC
GGCCGCGTTGCTGGACGACGCCACCGAGCTGGAACAGTGCGCGCGGCTGGCCACGGCGTTTTCGATGTGCCGGCTGGAAA
GCGGCGATGCACGCCGGATTACGCCCGAAGGCGTGCGCGACGCTGCCGCCGCCGTCGTCATCGGGGCGGTGCCGTGA

Upstream 100 bases:

>100_bases
GCAGGGCGCTGAGCGCCTTGCAGCAGCTGGCCGAGCAGGCGCTGCAGTGCGAAACCGCAGAGCAGGTGCGTGCGCTTGAA
GCACAGCGCGAGGGCCAGGC

Downstream 100 bases:

>100_bases
GCGCAGCCGTACACCGGCCGCAGCGCGCTGCGCTGTACGCGCCATCGCGGGCCGCACCGCCTTGCTGCGCTGCTATCTGG
CAGCCGCGCGCCTAGCCCTT

Product: 1-phosphofructokinase

Products: NA

Alternate protein names: Fructose 1-phosphate kinase

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALGVLGVGNAGVFEALFRERGIT
DHCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQGVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASA
AGARVLLDTSGAPLVAALAAAPVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRD
QQLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRITPEGVRDAAAAVVIGAVP

Sequences:

>Translated_318_residues
MSLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALGVLGVGNAGVFEALFRERGIT
DHCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQGVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASA
AGARVLLDTSGAPLVAALAAAPVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRD
QQLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRITPEGVRDAAAAVVIGAVP
>Mature_317_residues
SLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALGVLGVGNAGVFEALFRERGITD
HCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQGVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASAA
GARVLLDTSGAPLVAALAAAPVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRDQ
QLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRITPEGVRDAAAAVVIGAVP

Specific function: Unknown

COG id: COG1105

COG function: function code G; Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Escherichia coli, GI1788493, Length=272, Percent_Identity=40.8088235294118, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1788017, Length=281, Percent_Identity=29.5373665480427, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): K1PF_XANCP (P23354)

Other databases:

- EMBL:   M69242
- EMBL:   AE008922
- PIR:   A40944
- RefSeq:   NP_637725.1
- ProteinModelPortal:   P23354
- SMR:   P23354
- GeneID:   1002147
- GenomeReviews:   AE008922_GR
- KEGG:   xcc:XCC2371
- HOGENOM:   HBG670529
- OMA:   LIKPNTE
- ProtClustDB:   CLSK903530
- BioCyc:   XCAM190485:XCC2371-MONOMER
- BRENDA:   2.7.1.56
- InterPro:   IPR022463
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR017583
- TIGRFAMs:   TIGR03168
- TIGRFAMs:   TIGR03828

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.56

Molecular weight: Translated: 32593; Mature: 32461

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALG
CCCEEEEEEECCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VLGVGNAGVFEALFRERGITDHCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQ
EEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
GVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASAAGARVLLDTSGAPLVAALAA
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
APVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRD
HHHCCCEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECC
QQLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TPEGVRDAAAAVVIGAVP
CHHHHHHHHHEEEEECCC
>Mature Secondary Structure 
SLQAITVTLNPAIDQTIQLDRLQPGAVHRASSVRNDAGGKGINVAACLADWGSQVAALG
CCEEEEEEECCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VLGVGNAGVFEALFRERGITDHCHRVAGDTRTNLKLVEAQVNETTDINLPGLQLGQAHLQ
EEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
GVADHLAPLLRAGLPVVLSGSLPAGLPEDSWAQLQAQASAAGARVLLDTSGAPLVAALAA
HHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
APVAMPYAVKPNRHELEAWTGHPLGDHAALTAAAHALIARGIQLVVISMGTEGALFVQRD
HHHCCCEEECCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECC
QQLIARPPRLAQGSSVGAGDAMVAGLAAALLDDATELEQCARLATAFSMCRLESGDARRI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TPEGVRDAAAAVVIGAVP
CHHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655739; 12024217