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The map label for this gene is qacE [H]

Identifier: 66768014

GI number: 66768014

Start: 2029722

End: 2030054

Strand: Direct

Name: qacE [H]

Synonym: XC_1690

Alternate gene names: 66768014

Gene position: 2029722-2030054 (Clockwise)

Preceding gene: 66768012

Following gene: 66768015

Centisome position: 39.42

GC content: 66.07

Gene sequence:

>333_bases
ATGAAGCACTGGGTGTTTCTGGCGGTGGCAATCGTTGCGGAGGTGATGGCGACGGCGGCGCTCACATCCAGCGAAGGCTT
CACCCGGCGATGGCCGTCGCCGCTGACCGTGCTCGGCTATGCCGTGGCGTTCTATTGCCTGGCGGCGACGTTGCGGGTGA
TCCCGGTCGGCATCGCGTACGCGCTCTGTTCCGGAGCCGGCATCGTGCTGATCTCGCTGGTGGCCTGGCTGGTGCATGGC
CAGCGGCTGGATCTGCCGGCCATGCTGGGCAGGGCGCTGATCGTGGCCGGTGCGGTGGTGATCAATGTGTTCTCGAAGAT
GGCGCCGCAGTAA

Upstream 100 bases:

>100_bases
AGCGCGCGCGGTGCGTGCCGGCAATGGCGCGCAGCCCGGTGCTTGCATGCAAGCCGGTGGCTGCCGTCATGGTCGCGGCA
TTGAACGCGTGGAGACGAGG

Downstream 100 bases:

>100_bases
CGGCGCACGGCGGGGACACGTCTCCCGCGCGCCGAGCAAGACCGGCAATCGTCTGCATCGCGGCTGTCCACACGCTCCGC
AGCGAGGGTGCCGGGCAGTC

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MKHWVFLAVAIVAEVMATAALTSSEGFTRRWPSPLTVLGYAVAFYCLAATLRVIPVGIAYALCSGAGIVLISLVAWLVHG
QRLDLPAMLGRALIVAGAVVINVFSKMAPQ

Sequences:

>Translated_110_residues
MKHWVFLAVAIVAEVMATAALTSSEGFTRRWPSPLTVLGYAVAFYCLAATLRVIPVGIAYALCSGAGIVLISLVAWLVHG
QRLDLPAMLGRALIVAGAVVINVFSKMAPQ
>Mature_110_residues
MKHWVFLAVAIVAEVMATAALTSSEGFTRRWPSPLTVLGYAVAFYCLAATLRVIPVGIAYALCSGAGIVLISLVAWLVHG
QRLDLPAMLGRALIVAGAVVINVFSKMAPQ

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=52.7272727272727, Blast_Score=114, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11625; Mature: 11625

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHWVFLAVAIVAEVMATAALTSSEGFTRRWPSPLTVLGYAVAFYCLAATLRVIPVGIAY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALCSGAGIVLISLVAWLVHGQRLDLPAMLGRALIVAGAVVINVFSKMAPQ
HHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHWVFLAVAIVAEVMATAALTSSEGFTRRWPSPLTVLGYAVAFYCLAATLRVIPVGIAY
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALCSGAGIVLISLVAWLVHGQRLDLPAMLGRALIVAGAVVINVFSKMAPQ
HHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]