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The map label for this gene is purK [H]

Identifier: 66767938

GI number: 66767938

Start: 1936505

End: 1937647

Strand: Direct

Name: purK [H]

Synonym: XC_1614

Alternate gene names: 66767938

Gene position: 1936505-1937647 (Clockwise)

Preceding gene: 66767937

Following gene: 66767940

Centisome position: 37.61

GC content: 67.02

Gene sequence:

>1143_bases
ATGACTACGGTCGGCATCCTGGGCGGCGGCCAATTGGCGCGCATGCTGGTGTTGGCCGGTGCGCCGCTGGGGCTGCGGTT
TGCCGTGTTCGATCCGGCAGCCGACGCCTGCGCAGGGCAGGTGGCGCCGTTGCAGGTGGGCGCATTCGACGACGCAGCCG
CACTAGCTGGCTTCGCCGCGCAGGTGGACGTGCTCACCTTCGATTTCGAGAACGTACCGGCCGCCAGCGCGCAGCAGTTG
GCGACGCAGGTGCCGGTGTTCCCCAACCCTGCCGCACTGGCTATCGCGCAAGACCGGCTCAGCGAAAAAACCTTGTTCCG
CGAACTGGGTATCCCGGTGCCCGAATTTGCCGCCATCGATGACCGTGCCGGCCTGGATGCCGCACTGGCGCGCATTGGGG
CGCCATGCGTGCTCAAGACGCGACGCTTCGGCTACGACGGCAAGGGGCAGTTCCGGATCAAGACGCTTGCCGACGCCGAT
GCTGCGTGGGATGCCTTGGGTGCGCAGGCGGCCACGGCTGGCCTGATCGTGGAAGCCTTCGTGCCGTTCGAGCGCGAAGT
CAGCGTGGTCGCTGTGCGTGGCCGCGATGGCGGGTTTCGTGCCTGGCCATTGACCGAAAACTGGCATGTGGATGGCGTGC
TCTCGGCCAGCCTGGCGCCTGCCAGCGTGGACGCCGGGTTGCAAGAGGCGGCTGAAGCGCATGCGCGTGCGCTTGCCGAA
CGCCTGGACTATGTCGGCGTGTTTGCATTGGAGCTGTTCGTGCGCGAAGGCACCCTGCTGGCCAACGAAATGGCCCCGCG
CGTGCACAATTCCGGGCACTGGACGATCGAAGGCGCAGAAACTTCGCAGTTCGAAAACCACGTGCGGGCCGTGCTGGGCT
TGCCGCTCGGCAGCACTGCCATGCGTGGCCATGCCTGCATGCTGAACTGGCTGGGCGCCATGCCCGATGCAGCGGCCTTC
CTGGCAGTGCCTGGTGGGCATTGGCACGATTACGGCAAGCAGGCGCGTGATGGGCGCAAGGTGGGGCATTCGACGGTGCG
CGCGGATACGCCGGCGCTATTGGCGCAACTGCTTGGCGACGTTGGTCAGGCCTTGCAGCGCGATGCGCAGACGGCGCCGG
TTGTGGCGCGGTTGGCGCCTTAG

Upstream 100 bases:

>100_bases
CAGCGATGCTGTCGCCGGAGCAGCCGCAGATCGGTCAGGCATTGGCGCAGTTCCGCGCCAAGCAGACCGACGATGTGATG
GCCAGCGACGATCCCCGCCA

Downstream 100 bases:

>100_bases
CGTGCGCGTGGCGCTGCAAGCGGGGCAGTGCCGCTAAGTGCTGAGTGAGTGTTTCAACTGCGTGCTGCGTCCTTGAAGCG
TGAATGCAAATTCAAGGGCG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTTVGILGGGQLARMLVLAGAPLGLRFAVFDPAADACAGQVAPLQVGAFDDAAALAGFAAQVDVLTFDFENVPAASAQQL
ATQVPVFPNPAALAIAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGAPCVLKTRRFGYDGKGQFRIKTLADAD
AAWDALGAQAATAGLIVEAFVPFEREVSVVAVRGRDGGFRAWPLTENWHVDGVLSASLAPASVDAGLQEAAEAHARALAE
RLDYVGVFALELFVREGTLLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDAAAF
LAVPGGHWHDYGKQARDGRKVGHSTVRADTPALLAQLLGDVGQALQRDAQTAPVVARLAP

Sequences:

>Translated_380_residues
MTTVGILGGGQLARMLVLAGAPLGLRFAVFDPAADACAGQVAPLQVGAFDDAAALAGFAAQVDVLTFDFENVPAASAQQL
ATQVPVFPNPAALAIAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGAPCVLKTRRFGYDGKGQFRIKTLADAD
AAWDALGAQAATAGLIVEAFVPFEREVSVVAVRGRDGGFRAWPLTENWHVDGVLSASLAPASVDAGLQEAAEAHARALAE
RLDYVGVFALELFVREGTLLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDAAAF
LAVPGGHWHDYGKQARDGRKVGHSTVRADTPALLAQLLGDVGQALQRDAQTAPVVARLAP
>Mature_379_residues
TTVGILGGGQLARMLVLAGAPLGLRFAVFDPAADACAGQVAPLQVGAFDDAAALAGFAAQVDVLTFDFENVPAASAQQLA
TQVPVFPNPAALAIAQDRLSEKTLFRELGIPVPEFAAIDDRAGLDAALARIGAPCVLKTRRFGYDGKGQFRIKTLADADA
AWDALGAQAATAGLIVEAFVPFEREVSVVAVRGRDGGFRAWPLTENWHVDGVLSASLAPASVDAGLQEAAEAHARALAER
LDYVGVFALELFVREGTLLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTAMRGHACMLNWLGAMPDAAAFL
AVPGGHWHDYGKQARDGRKVGHSTVRADTPALLAQLLGDVGQALQRDAQTAPVVARLAP

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=358, Percent_Identity=37.7094972067039, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788155, Length=311, Percent_Identity=28.9389067524116, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=408, Percent_Identity=32.3529411764706, Blast_Score=202, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39788; Mature: 39656

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVGILGGGQLARMLVLAGAPLGLRFAVFDPAADACAGQVAPLQVGAFDDAAALAGFAA
CCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCEEEECCCCCHHHHHHHHH
QVDVLTFDFENVPAASAQQLATQVPVFPNPAALAIAQDRLSEKTLFRELGIPVPEFAAID
EEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
DRAGLDAALARIGAPCVLKTRRFGYDGKGQFRIKTLADADAAWDALGAQAATAGLIVEAF
CCCCHHHHHHHHCCCEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEC
VPFEREVSVVAVRGRDGGFRAWPLTENWHVDGVLSASLAPASVDAGLQEAAEAHARALAE
CCCCCCEEEEEEECCCCCEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
RLDYVGVFALELFVREGTLLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTA
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHH
MRGHACMLNWLGAMPDAAAFLAVPGGHWHDYGKQARDGRKVGHSTVRADTPALLAQLLGD
HCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHH
VGQALQRDAQTAPVVARLAP
HHHHHHHCCCCCCEEEECCC
>Mature Secondary Structure 
TTVGILGGGQLARMLVLAGAPLGLRFAVFDPAADACAGQVAPLQVGAFDDAAALAGFAA
CEEEEECCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCEEEECCCCCHHHHHHHHH
QVDVLTFDFENVPAASAQQLATQVPVFPNPAALAIAQDRLSEKTLFRELGIPVPEFAAID
EEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
DRAGLDAALARIGAPCVLKTRRFGYDGKGQFRIKTLADADAAWDALGAQAATAGLIVEAF
CCCCHHHHHHHHCCCEEEEHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEEC
VPFEREVSVVAVRGRDGGFRAWPLTENWHVDGVLSASLAPASVDAGLQEAAEAHARALAE
CCCCCCEEEEEEECCCCCEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
RLDYVGVFALELFVREGTLLANEMAPRVHNSGHWTIEGAETSQFENHVRAVLGLPLGSTA
HHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCHH
MRGHACMLNWLGAMPDAAAFLAVPGGHWHDYGKQARDGRKVGHSTVRADTPALLAQLLGD
HCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHH
VGQALQRDAQTAPVVARLAP
HHHHHHHCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]