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The map label for this gene is purE [H]

Identifier: 66767937

GI number: 66767937

Start: 1936005

End: 1936508

Strand: Direct

Name: purE [H]

Synonym: XC_1613

Alternate gene names: 66767937

Gene position: 1936005-1936508 (Clockwise)

Preceding gene: 66767933

Following gene: 66767938

Centisome position: 37.6

GC content: 66.67

Gene sequence:

>504_bases
ATGACCTCCAACCACTCCGCGCCGCTGGTCGGCATCGTGATGGGTTCCCGTTCGGACTGGGACACCATGCAACACGCAGC
TCAGAAGCTCGATGCACTGGGCGTGCCGTACGAGGTCAAGGTGGTCTCGGCCCACCGCACACCGGATGTGTTGTTCACCT
ACGCCGAACAGGCAGGCGAGCGCGGCCTGCGCGCGATCATCGCCGGCGCTGGCGGTGCCGCGCATCTGCCCGGCATGCTG
GCGGCCAAGACCGCAGTGCCCGTGCTGGGCGTGCCGGTGCAGTCCAAGGCGCTCAACGGCATGGATTCGCTGCTGTCGAT
CGTGCAGATGCCAGCCGGTATTCCGGTGGCCACCTTCGCGATCGGCAATGCGGGCGCTGCCAATGCGGCCCTGTTTGCAG
CAGCGATGCTGTCGCCGGAGCAGCCGCAGATCGGTCAGGCATTGGCGCAGTTCCGCGCCAAGCAGACCGACGATGTGATG
GCCAGCGACGATCCCCGCCAATGA

Upstream 100 bases:

>100_bases
GGTGTCGGGGGAGCACAGCAGGTCGAGCAGTTTGCGATCCATCGAAGTCTTGTCTTGCGTGGAAGATGGCTAGAATACGT
CTTTACAGCAGGGCAGGGCC

Downstream 100 bases:

>100_bases
CTACGGTCGGCATCCTGGGCGGCGGCCAATTGGCGCGCATGCTGGTGTTGGCCGGTGCGCCGCTGGGGCTGCGGTTTGCC
GTGTTCGATCCGGCAGCCGA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTSNHSAPLVGIVMGSRSDWDTMQHAAQKLDALGVPYEVKVVSAHRTPDVLFTYAEQAGERGLRAIIAGAGGAAHLPGML
AAKTAVPVLGVPVQSKALNGMDSLLSIVQMPAGIPVATFAIGNAGAANAALFAAAMLSPEQPQIGQALAQFRAKQTDDVM
ASDDPRQ

Sequences:

>Translated_167_residues
MTSNHSAPLVGIVMGSRSDWDTMQHAAQKLDALGVPYEVKVVSAHRTPDVLFTYAEQAGERGLRAIIAGAGGAAHLPGML
AAKTAVPVLGVPVQSKALNGMDSLLSIVQMPAGIPVATFAIGNAGAANAALFAAAMLSPEQPQIGQALAQFRAKQTDDVM
ASDDPRQ
>Mature_166_residues
TSNHSAPLVGIVMGSRSDWDTMQHAAQKLDALGVPYEVKVVSAHRTPDVLFTYAEQAGERGLRAIIAGAGGAAHLPGMLA
AKTAVPVLGVPVQSKALNGMDSLLSIVQMPAGIPVATFAIGNAGAANAALFAAAMLSPEQPQIGQALAQFRAKQTDDVMA
SDDPRQ

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=166, Percent_Identity=63.2530120481928, Blast_Score=177, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324702, Length=153, Percent_Identity=54.2483660130719, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17184; Mature: 17053

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSNHSAPLVGIVMGSRSDWDTMQHAAQKLDALGVPYEVKVVSAHRTPDVLFTYAEQAGE
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
RGLRAIIAGAGGAAHLPGMLAAKTAVPVLGVPVQSKALNGMDSLLSIVQMPAGIPVATFA
CCCEEEEECCCCHHHCCCHHHHHHCCCEECCCCHHHHHCCHHHHHHHHHCCCCCCEEEEE
IGNAGAANAALFAAAMLSPEQPQIGQALAQFRAKQTDDVMASDDPRQ
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSNHSAPLVGIVMGSRSDWDTMQHAAQKLDALGVPYEVKVVSAHRTPDVLFTYAEQAGE
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
RGLRAIIAGAGGAAHLPGMLAAKTAVPVLGVPVQSKALNGMDSLLSIVQMPAGIPVATFA
CCCEEEEECCCCHHHCCCHHHHHHCCCEECCCCHHHHHCCHHHHHHHHHCCCCCCEEEEE
IGNAGAANAALFAAAMLSPEQPQIGQALAQFRAKQTDDVMASDDPRQ
CCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]