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The map label for this gene is nuoF [H]

Identifier: 66767918

GI number: 66767918

Start: 1912019

End: 1913353

Strand: Direct

Name: nuoF [H]

Synonym: XC_1594

Alternate gene names: 66767918

Gene position: 1912019-1913353 (Clockwise)

Preceding gene: 66767917

Following gene: 66767919

Centisome position: 37.14

GC content: 63.67

Gene sequence:

>1335_bases
ATGGCACATCATCACGCACCCTCAGGCCCGGTCGGTCCGGCGCCGCTGCCGCATCAGGTCGTCTACACGACCCTGCACTA
CGACACCCCGTGGTCGTACGAAAGCTATCTGAAGACCGGTGGCTACGCCGCGCTGCGCAAGATCCTCGAAGAGAAGATCC
CGCCGGGCGACGTCATCGAAATGGTGAAGGCTTCCAACCTGCGCGGCCGCGGTGGCGCGGGCTTCCCGACTGGTCTGAAG
TGGTCCTTCATGCCCAAGGGCACCATGCAGAAGTACATCCTGTGCAATTCGGACGAATCCGAGCCGGGGACCTGCAAGGA
CCGCGACATCCTGCGTTACAACCCGCACTCGGTGGTGGAGGGCATGGCAATCGCCTGCTACGCCACTGGCTCGACCGTGG
GCTACAACTATCTGCGTGGTGAGTTCCATCACGAGCCGTTCGAAAATTTCGAGCTGGCACTGGCCGATGCCTATGCCAAC
GGCTGGCTGGGCAAGAACATTCTCGGCAGCGGCGTGGATATCGATATCTATGGTGCGCTGGGCGCTGGCGCTTACATCTG
CGGCGAAGAAACCGCGCTGATGGAATCGCTGGAAGGCAAGAAGGGCCAGCCGCGCTACAAGCCGCCGTTCCCGGCGAACT
TCGGCCTGTACGGCAAGCCCACCACCATCAACAACACCGAGACCTACGCGTCGGTGCCAGCGATCATTCGCAATGGCCCG
GAGTGGTTCCTGGGGTTGAGCAAGACCAAGAACGGCGGCCCGAAGATCTTCTCGGTGTCCGGCTGCGTGCAGAAGGGCGG
CAATTTCGAAGTGCCGCTCGGCACCACCTTCGACGAACTGCTGGAAATGGCCGGTGGCCTGCGTCCGGGCCGCAAGCTCA
AGGGCGTGGTGCCCGGCGGCGTGTCGATGCCGGTGCTGAAGGCCGACCAGGTCGCTGGCCTGCAGATGGATTACGACACC
CTGCGCGCGCTTGGCACCGGTCTGGGTTCCGGCGCCATCGTGGTGCTGGATGACAGCGTGTGCTGCGTGCGGTTTGCCTG
CCGCATCTCGCAGTTCTTCCACAAGGAATCCTGCGGCCAGTGCACCCCGTGCCGCGAAGGCACCGGCTGGATGCATCGCG
TGCTGGAGCGCATCGTCGCCGGCAAGGCCACGATGGAAGACCTCCACCAGCTGCGCACCGTGGCCGGCCAGATCGAAGGT
CACACCATCTGCGCGTTCGGCGAAGCGGCGGCATGGCCGATCCAGGGCTTCCTGCGCCAGTTCTGGGACGAATTCGAGTA
CTACATCGTCAACGGTCGTTCGATCGTCGACACGCATGTCGGAGTGGCCGCATGA

Upstream 100 bases:

>100_bases
GGCCTGCTCTGCAGCGCCGATGATGGTCATCAACGGCCATTACCACGAGCACCTGACGAAAGAAAAGGTCGACGCGCTAC
TGGACGGGCTGGAGTAAGGA

Downstream 100 bases:

>100_bases
GCGCCCAACCAGTGAACCCGAACGTGCCACCGGACCATGTCACCGTCGAGATCGACGGGCAGTCGCTGGTGGTGCCGAAG
GGCTCGATGATCATCCAGGC

Product: NADH-ubiquinone oxidoreductase NQO1 subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MAHHHAPSGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPGDVIEMVKASNLRGRGGAGFPTGLK
WSFMPKGTMQKYILCNSDESEPGTCKDRDILRYNPHSVVEGMAIACYATGSTVGYNYLRGEFHHEPFENFELALADAYAN
GWLGKNILGSGVDIDIYGALGAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPTTINNTETYASVPAIIRNGP
EWFLGLSKTKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGVVPGGVSMPVLKADQVAGLQMDYDT
LRALGTGLGSGAIVVLDDSVCCVRFACRISQFFHKESCGQCTPCREGTGWMHRVLERIVAGKATMEDLHQLRTVAGQIEG
HTICAFGEAAAWPIQGFLRQFWDEFEYYIVNGRSIVDTHVGVAA

Sequences:

>Translated_444_residues
MAHHHAPSGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPGDVIEMVKASNLRGRGGAGFPTGLK
WSFMPKGTMQKYILCNSDESEPGTCKDRDILRYNPHSVVEGMAIACYATGSTVGYNYLRGEFHHEPFENFELALADAYAN
GWLGKNILGSGVDIDIYGALGAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPTTINNTETYASVPAIIRNGP
EWFLGLSKTKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGVVPGGVSMPVLKADQVAGLQMDYDT
LRALGTGLGSGAIVVLDDSVCCVRFACRISQFFHKESCGQCTPCREGTGWMHRVLERIVAGKATMEDLHQLRTVAGQIEG
HTICAFGEAAAWPIQGFLRQFWDEFEYYIVNGRSIVDTHVGVAA
>Mature_443_residues
AHHHAPSGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPGDVIEMVKASNLRGRGGAGFPTGLKW
SFMPKGTMQKYILCNSDESEPGTCKDRDILRYNPHSVVEGMAIACYATGSTVGYNYLRGEFHHEPFENFELALADAYANG
WLGKNILGSGVDIDIYGALGAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPTTINNTETYASVPAIIRNGPE
WFLGLSKTKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGVVPGGVSMPVLKADQVAGLQMDYDTL
RALGTGLGSGAIVVLDDSVCCVRFACRISQFFHKESCGQCTPCREGTGWMHRVLERIVAGKATMEDLHQLRTVAGQIEGH
TICAFGEAAAWPIQGFLRQFWDEFEYYIVNGRSIVDTHVGVAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=410, Percent_Identity=46.5853658536585, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI260656005, Length=410, Percent_Identity=46.5853658536585, Blast_Score=378, Evalue=1e-105,
Organism=Escherichia coli, GI1788620, Length=432, Percent_Identity=42.1296296296296, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17531727, Length=429, Percent_Identity=42.6573426573427, Blast_Score=356, Evalue=1e-98,
Organism=Drosophila melanogaster, GI19920794, Length=411, Percent_Identity=46.9586374695864, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI45550452, Length=415, Percent_Identity=44.578313253012, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24653819, Length=417, Percent_Identity=34.2925659472422, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24653817, Length=358, Percent_Identity=34.0782122905028, Blast_Score=227, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48143; Mature: 48012

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHHHAPSGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPGDVIE
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHH
MVKASNLRGRGGAGFPTGLKWSFMPKGTMQKYILCNSDESEPGTCKDRDILRYNPHSVVE
HHHHCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEECCHHHHC
GMAIACYATGSTVGYNYLRGEFHHEPFENFELALADAYANGWLGKNILGSGVDIDIYGAL
CCEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCEEEEECC
GAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPTTINNTETYASVPAIIRNGP
CCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
EWFLGLSKTKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGVVPGG
HHEEEECCCCCCCCEEEEEHHHHHCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VSMPVLKADQVAGLQMDYDTLRALGTGLGSGAIVVLDDSVCCVRFACRISQFFHKESCGQ
CCCCEECCCCCCCCEECHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCC
CTPCREGTGWMHRVLERIVAGKATMEDLHQLRTVAGQIEGHTICAFGEAAAWPIQGFLRQ
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
FWDEFEYYIVNGRSIVDTHVGVAA
HHHCCEEEEECCCEEEECCCCCCC
>Mature Secondary Structure 
AHHHAPSGPVGPAPLPHQVVYTTLHYDTPWSYESYLKTGGYAALRKILEEKIPPGDVIE
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHH
MVKASNLRGRGGAGFPTGLKWSFMPKGTMQKYILCNSDESEPGTCKDRDILRYNPHSVVE
HHHHCCCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEECCHHHHC
GMAIACYATGSTVGYNYLRGEFHHEPFENFELALADAYANGWLGKNILGSGVDIDIYGAL
CCEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCEEEEECC
GAGAYICGEETALMESLEGKKGQPRYKPPFPANFGLYGKPTTINNTETYASVPAIIRNGP
CCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
EWFLGLSKTKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGVVPGG
HHEEEECCCCCCCCEEEEEHHHHHCCCCEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCC
VSMPVLKADQVAGLQMDYDTLRALGTGLGSGAIVVLDDSVCCVRFACRISQFFHKESCGQ
CCCCEECCCCCCCCEECHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCC
CTPCREGTGWMHRVLERIVAGKATMEDLHQLRTVAGQIEGHTICAFGEAAAWPIQGFLRQ
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
FWDEFEYYIVNGRSIVDTHVGVAA
HHHCCEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA