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The map label for this gene is gltX [H]

Identifier: 66767755

GI number: 66767755

Start: 1723717

End: 1725120

Strand: Direct

Name: gltX [H]

Synonym: XC_1429

Alternate gene names: 66767755

Gene position: 1723717-1725120 (Clockwise)

Preceding gene: 66767754

Following gene: 66767756

Centisome position: 33.48

GC content: 65.74

Gene sequence:

>1404_bases
ATGACCTGCCGCACCCGTTTTGCCCCCAGCCCCACCGGTTACCTGCACATCGGCGGCGCACGCACCGCCCTGTACTGCTG
GCTGGAGGCACGTCACCGCGGCGGGCAGTTCGTGCTGCGCATCGAAGACACCGACCGTGAGCGCAGCACCCAGGTCGCCA
TCGACGCCATCCTGGAAGCCATGGAGTGGCTGGGCCTGGGCTACGACGAAGGCCCGATCTACCAGACCCAGCGCATCGCC
CGTTACCAGGAGGTGGCCGAGCAGCTGCTGGCGCAGGGCAAGGCCTATTACGCCTACGAGACCCGTGAGGAGCTCGACGC
GATGCGCGAGGCCGCGATGGCCAAGCAGGAAAAGCCGCGCTACAACGGCGCCGCGCGCGAGCAGCAGCTGCCGTATCGCG
ACGACCCGAACCGGGTGATCCGCTTCAAGAACCCGCTCGCGGGCACGGTGGTGTTCGACGACCTGATCAAGGGCCGCATC
GAGATCGCCAACAGCGAGCTCGACGACATGGTGATCTTCCGCCCGGATGGCTACCCCACCTACAACTTCGCGGTGGTGGT
GGACGACTGGGACATGGGCATCACCGAGGTGATCCGCGGCGACGACCACATCAACAACACCCCGCGCCAGATCAACATCT
ACGAAGCGCTGGGCGCACCGGTACCCAAGTTCGCGCACATGCCGATGATCCTGGACGAGCAGGGCGCCAAGCTCTCCAAG
CGCACTGGCGCGGCCGATGTCATGCAGTACAAGGACGCCGGCTACCTGCCGCATGCGCTGATCAATTACCTGGCCCGCCT
AGGTTGGTCGCATGGCGACCAGGAGCTGTTCAGCCAGCAGGAGTTGCTGGACCTGTTCGACGTCAAGGACGTCAATTCCA
AGGCCGCGCGCCTGGACATGGCCAAGCTCGGCTGGGTGAATCAGCATTACTTGAAGACCGACGACCCGGCCAGCATCGCG
CCGCAGCTGGAATACCAGCTCCGCAAGCTGGGCATTGATGTGGCCGCCGGCCCGGCCGCTGCCGATGTGGTGGTGGCGCT
GCGCGAGCGCGTGCAGACGCTCAAGGAAATGGCCGAAAAAGCCGTGGTCTGGTACCAGCCGCTGGAAACCTACGACGAAG
CCGCGGTGATCAAGCACCTGAAACTGGGCGCGGAAGTGCCGCTGGGCAAGGCGCGCGAGATGCTCGCTGCGCTGAACGAG
TGGAGCGTGGAGAACGTATCGGCGGCGCTGCATGCCGCTGCCGCGGCGCTGGAACTGGGCATGGGCAAGGTGGCCCAGCC
GCTGCGGGTGGCCATCACCGGCACCCAGGTCAGCCCGGACATTTCGCAGACGGTGTACCTGGCCGGGCGCGAGGGTGCCT
TGAAACGCATCGATGCGGCACTCATCAAGATTGGAGCGGCCTGA

Upstream 100 bases:

>100_bases
GGTTTACGGCGACCTGTTGCGCAACACCTGAGCGGGCGGGCCGGGCAGGGCACGGCTGCGCAAGGTAAAATCGGGCCACT
CCCGTTCCGCCGAGCGCTCC

Downstream 100 bases:

>100_bases
CGCCGGAGCCTGTATGACCAAGCACACGCACACCCAAACGCACGACCAGGAACACGCCTGCACGGCCCCGCACCACCACG
TGGACGATGCCAACAGCTTC

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEAMEWLGLGYDEGPIYQTQRIA
RYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPRYNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRI
EIANSELDDMVIFRPDGYPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSK
RTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDMAKLGWVNQHYLKTDDPASIA
PQLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEKAVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNE
WSVENVSAALHAAAAALELGMGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA

Sequences:

>Translated_467_residues
MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEAMEWLGLGYDEGPIYQTQRIA
RYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPRYNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRI
EIANSELDDMVIFRPDGYPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSK
RTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDMAKLGWVNQHYLKTDDPASIA
PQLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEKAVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNE
WSVENVSAALHAAAAALELGMGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA
>Mature_466_residues
TCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEAMEWLGLGYDEGPIYQTQRIAR
YQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPRYNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRIE
IANSELDDMVIFRPDGYPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSKR
TGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDMAKLGWVNQHYLKTDDPASIAP
QLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEKAVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNEW
SVENVSAALHAAAAALELGMGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=326, Percent_Identity=37.4233128834356, Blast_Score=215, Evalue=7e-56,
Organism=Escherichia coli, GI1788743, Length=461, Percent_Identity=54.6637744034707, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI226510925, Length=242, Percent_Identity=39.6694214876033, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71993394, Length=473, Percent_Identity=29.8097251585624, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324540, Length=495, Percent_Identity=30.7070707070707, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6321192, Length=210, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24665321, Length=498, Percent_Identity=32.1285140562249, Blast_Score=235, Evalue=5e-62,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 51984; Mature: 51853

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEA
CCCCCCCCCCCCCEEEECCCCEEHEEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
MEWLGLGYDEGPIYQTQRIARYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCC
YNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRIEIANSELDDMVIFRPDGYPT
CCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCHHEECCCCCCCEEEECCCCCCC
YNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSK
EEEEEEEECCCCCHHHHHCCCCCCCCCCCEEEEHHHHCCCCCCHHCCCEEECCCCCCHHH
RTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDM
HCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AKLGWVNQHYLKTDDPASIAPQLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEK
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNEWSVENVSAALHAAAAALELG
HEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
MGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA
CCHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEA
CCCCCCCCCCCCEEEECCCCEEHEEEHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHH
MEWLGLGYDEGPIYQTQRIARYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPR
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCC
YNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRIEIANSELDDMVIFRPDGYPT
CCCCCHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCHHEECCCCCCCEEEECCCCCCC
YNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSK
EEEEEEEECCCCCHHHHHCCCCCCCCCCCEEEEHHHHCCCCCCHHCCCEEECCCCCCHHH
RTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDM
HCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AKLGWVNQHYLKTDDPASIAPQLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEK
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNEWSVENVSAALHAAAAALELG
HEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
MGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA
CCHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]