Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 66767552

GI number: 66767552

Start: 1499366

End: 1500784

Strand: Reverse

Name: bioA [H]

Synonym: XC_1225

Alternate gene names: 66767552

Gene position: 1500784-1499366 (Counterclockwise)

Preceding gene: 66767562

Following gene: 66767551

Centisome position: 29.15

GC content: 67.37

Gene sequence:

>1419_bases
ATGCATCGACATGTTCATGAGCCCGAAATCCTAGCAGACCCGGCAGCCTTCGAAGCTGCCGAACATTGGCGGCAACGCGA
TCTTGCGGTGGTGTGGCACCCCTGCACCCAGATGCGCGAGCACCCGCACACACTACCCCTGGTGCCGATCGCACGTGGCG
ACGGCGCCTGGCTGATCGGCCACGATGGCCGCCACTATCTGGATGCGGTCAGCAGCTGGTGGACCAACCTGTTTGGACAC
GCCGAACCGCGCATCGGCGCGGCCATCGCGCAGCAGGCCGGCAGGTTGGAACAGGTGATGCTGGCCGGCTTCACGCATGC
GCCCGCCGTGCAACTGGCCGAGCGGCTGTTGGCCATCGCGCCGCGCCAGCCCGACCGCGCGCCACTGGCCAAGGTGTTCT
ACGCCGACAATGGCTCGGCCGGGGTGGAAGTCGCCTTGAAGATGGCCTTCCACTATTTCCACAACCGTGACGAGCACCGC
CGCACGCGTTTCATCGCGCTGGAGAACGGTTACCACGGCGAGACCATCGGTGCGCTGTCGGTGGGCGACATTCCGCTGTA
CCGCCGCGTGTACGCGCCGCTGTTGCTGGAATCGATCTTCGCGCCTTCGCCCGATGCGTACCTGGCCGAGCCGGGACAGA
GCGCCGAGGACTACGCGTTGCAGGCGGCCGATGCACTGCAGCATCTGCTGGAGCAATCCCCGGGCGAAATCTGCGCCTTG
ATCCTGGAGCCGCGGGTGCAGTGCGCCGGCGGCATGCGCATGTATCACCCGGCCTACCTGCGCCGCGCGCGCGAACTGTG
CGATGCGCATGGCGTGTTCCTGATCGCCGACGAGATCGCCACCGGCTTTGGCCGCACCGGCACCTTGTTCGCCTGCGAAC
AGGCCGGCGTGATGCCGGATCTGTTGTGCCTGTCGAAAGGACTCACCGGTGGCTTCCTGCCCCTGTCGGCGGTACTGGCC
ACGCAGCAGCTGTATGACGCGTTTCTGGATGACTCGCGCGAGCGCGCCTTCCTGCATTCGCACAGCTACACCGGCAACCC
GCTGGCGTGTGCGGCGGCGCTGGCGACGCTGCAGATCTTCGCCGACGACGACATCATTGCGCGTAACCAACGTACCGCTG
CACACATGACCCAGCTCGCTGCGCAGATCGGCGAGCACAGCGCGGTGGCCGACGTGCGCCAGGCCGGCATGATCGTGGCC
TTCGAGCTCACCCAGGGCGGCGACAAGCGCACGCCCTTCCCCGCCGCCGCGCGCGTGGGCCTGCAGGCCTACCGCGCTGC
ATTGGCACGTGGCGTGGTGCTGCGCCCGTTGGGCGACGTGCTGTACTGGATGCCGCCGTATTGCGTGGACGACGCACAGC
TTGCGCTGCTTGCCGACACCACCCGCCACGCCATCGCCAAGGCCGTTGCATGCGCCTGA

Upstream 100 bases:

>100_bases
CGGAACGGCCCTTCGCCCAGATCGGTGATCTTGTGGATGGTCGGCAGACGCGTGCTCATGCGCAGCACGCAGCGGCGGAG
CCGGCCGATAGAATAGGCAG

Downstream 100 bases:

>100_bases
CCCGTTCGTATGTTGCATTGCCGCTGCACAGCGGCGGCGATGTCACGCTGCCGGAGGAATCGGCCAACCACCTGCTGCGT
GTGCTGCGGCTGCGCGAAGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MHRHVHEPEILADPAAFEAAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIARGDGAWLIGHDGRHYLDAVSSWWTNLFGH
AEPRIGAAIAQQAGRLEQVMLAGFTHAPAVQLAERLLAIAPRQPDRAPLAKVFYADNGSAGVEVALKMAFHYFHNRDEHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLESIFAPSPDAYLAEPGQSAEDYALQAADALQHLLEQSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGVFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLQIFADDDIIARNQRTAAHMTQLAAQIGEHSAVADVRQAGMIVA
FELTQGGDKRTPFPAAARVGLQAYRAALARGVVLRPLGDVLYWMPPYCVDDAQLALLADTTRHAIAKAVACA

Sequences:

>Translated_472_residues
MHRHVHEPEILADPAAFEAAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIARGDGAWLIGHDGRHYLDAVSSWWTNLFGH
AEPRIGAAIAQQAGRLEQVMLAGFTHAPAVQLAERLLAIAPRQPDRAPLAKVFYADNGSAGVEVALKMAFHYFHNRDEHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLESIFAPSPDAYLAEPGQSAEDYALQAADALQHLLEQSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGVFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLQIFADDDIIARNQRTAAHMTQLAAQIGEHSAVADVRQAGMIVA
FELTQGGDKRTPFPAAARVGLQAYRAALARGVVLRPLGDVLYWMPPYCVDDAQLALLADTTRHAIAKAVACA
>Mature_472_residues
MHRHVHEPEILADPAAFEAAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIARGDGAWLIGHDGRHYLDAVSSWWTNLFGH
AEPRIGAAIAQQAGRLEQVMLAGFTHAPAVQLAERLLAIAPRQPDRAPLAKVFYADNGSAGVEVALKMAFHYFHNRDEHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLESIFAPSPDAYLAEPGQSAEDYALQAADALQHLLEQSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGVFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLQIFADDDIIARNQRTAAHMTQLAAQIGEHSAVADVRQAGMIVA
FELTQGGDKRTPFPAAARVGLQAYRAALARGVVLRPLGDVLYWMPPYCVDDAQLALLADTTRHAIAKAVACA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=386, Percent_Identity=28.4974093264249, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=26.1282660332542, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=25.8293838862559, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=26.5984654731458, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557809, Length=427, Percent_Identity=26.463700234192, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI24119277, Length=429, Percent_Identity=24.9417249417249, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=25.5384615384615, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=41.7233560090703, Blast_Score=292, Evalue=4e-80,
Organism=Escherichia coli, GI1789759, Length=429, Percent_Identity=30.3030303030303, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI145693181, Length=355, Percent_Identity=30.4225352112676, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=30.9756097560976, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=29.4964028776978, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=29.9019607843137, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1786349, Length=311, Percent_Identity=29.5819935691318, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=27.7027027027027, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=423, Percent_Identity=23.8770685579196, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=23.943661971831, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=301, Percent_Identity=26.578073089701, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=463, Percent_Identity=31.7494600431965, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323470, Length=432, Percent_Identity=27.3148148148148, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=361, Percent_Identity=25.7617728531856, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=28.3482142857143, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI161085790, Length=437, Percent_Identity=29.2906178489703, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21357415, Length=428, Percent_Identity=26.8691588785047, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356575, Length=420, Percent_Identity=26.1904761904762, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 51509; Mature: 51509

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRHVHEPEILADPAAFEAAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIARGDGAWLIG
CCCCCCCCCHHCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCCEEEEECCCCEEEEE
HDGRHYLDAVSSWWTNLFGHAEPRIGAAIAQQAGRLEQVMLAGFTHAPAVQLAERLLAIA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PRQPDRAPLAKVFYADNGSAGVEVALKMAFHYFHNRDEHRRTRFIALENGYHGETIGALS
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEECEEE
VGDIPLYRRVYAPLLLESIFAPSPDAYLAEPGQSAEDYALQAADALQHLLEQSPGEICAL
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEE
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGVFLIADEIATGFGRTGTLFACEQAGVMPD
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCCCHH
LLCLSKGLTGGFLPLSAVLATQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLQIF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHEE
ADDDIIARNQRTAAHMTQLAAQIGEHSAVADVRQAGMIVAFELTQGGDKRTPFPAAARVG
ECCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHH
LQAYRAALARGVVLRPLGDVLYWMPPYCVDDAQLALLADTTRHAIAKAVACA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHRHVHEPEILADPAAFEAAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIARGDGAWLIG
CCCCCCCCCHHCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCCEEEEECCCCEEEEE
HDGRHYLDAVSSWWTNLFGHAEPRIGAAIAQQAGRLEQVMLAGFTHAPAVQLAERLLAIA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PRQPDRAPLAKVFYADNGSAGVEVALKMAFHYFHNRDEHRRTRFIALENGYHGETIGALS
CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEECEEE
VGDIPLYRRVYAPLLLESIFAPSPDAYLAEPGQSAEDYALQAADALQHLLEQSPGEICAL
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEE
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGVFLIADEIATGFGRTGTLFACEQAGVMPD
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCCCHH
LLCLSKGLTGGFLPLSAVLATQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLQIF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHEE
ADDDIIARNQRTAAHMTQLAAQIGEHSAVADVRQAGMIVAFELTQGGDKRTPFPAAARVG
ECCCEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHH
LQAYRAALARGVVLRPLGDVLYWMPPYCVDDAQLALLADTTRHAIAKAVACA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]