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The map label for this gene is tktA [H]

Identifier: 66767261

GI number: 66767261

Start: 1113412

End: 1115412

Strand: Reverse

Name: tktA [H]

Synonym: XC_0929

Alternate gene names: 66767261

Gene position: 1115412-1113412 (Counterclockwise)

Preceding gene: 66767262

Following gene: 66767257

Centisome position: 21.66

GC content: 65.12

Gene sequence:

>2001_bases
ATGACCCAGCCCACCCGCCGCCAGCTGGCCAACGCCATCCGTTTCCTCGCCGCCGATGCGGTCGAAGCCGCAAAGTCCGG
CCACCCCGGCATGCCCATGGGCATGGCCGATATCGCCGAAGTGCTGTGGAACGATTTCTTCCGGCACAACCCGAACAATC
CGCAGTGGTTCAATCGCGACCGTTTCGTGCTGTCCAACGGGCACGGGTCGATGCTGCAGTACGCGCTGCTGCACCTGTCC
GGCTACGACCTGCCGATCGAGCAGCTCAAGCAGTTCCGTCAGTTGCACAGCAAGACCGCCGGCCACCCCGAGCGCAGCGA
AACGCCTGGGGTGGAAACCACCACCGGGCCGCTTGGGCAGGGCTTTGCCAATGCAGTCGGGTTCGCGCTGGCCGAGAAGT
TGCTGGCACAGCGTTATAACCGGCCCGAGCTGGAAATCGTCGACCACCGCACCTGGGTGTTCATGGGCGACGGTTGCATG
ATGGAGGGCATCTCGCACGAGGCGGCCTCGCTGGCCGGTACCTGGGGCCTGGGTAAGCTGGTCGCGTTCTGGGACAACAA
CCAGATCTCCATCGACGGCAACACTGCCGGCTGGTTCAGTGACAACACCCCGGCACGCTTCGAAGCCTATGGCTGGCATG
TGATCCGTGATGTGGACGGGCACGACGCCGACAAGATCAAGGCGGCCATCGAGGCGGCGCTGGAAAACAGCGACAAGCCC
ACGCTGATCTGCTGCCGCACCAAGATCGGCTTCGGTGCACCCACCAAGTCGGGCAAAGAATCCTCGCACGGCGCACCGTT
GGGCAAGGAAGAGCTGGAAGGCGCGCGCAAGGCGCTGGAATGGCCGTACGGCCCGTTCGAGATTCCCGAAGAGATCTATG
CCGGCTGGCGCGCAGGTGGCACCGGCACGCTGCGTCAGGCCGAGTGGGAGCAGCTGTTCGACAAGTACGCCAAGCAGTAC
GGCGAACAGGCCGACGAGCTGACCCGCCGTTCGCGTGGCGAGTTGCCGGCCGACTTCATCGTCCAGGCCGATGCCTACAT
CGCCAAGGCGCAGGAAGACGGCCAGACCATCGCCTCGCGCAAGGCATCGCAGCTGGCGATCGAAGCGTTCGCACCGCTGC
TGCCGGAACTGGTCGGCGGCTCGGCCGACCTGGCGCATTCCAACCTCACCTTGTGGAAGGCCAGCAAGTCGGTCGCCACC
GACGACCCGAACGCCAACTACGTGTATTACGGCGTGCGCGAATTCGGCATGACCGCCATTGCCAACGGCTTGGCGCTGCA
TGGTGGCTTCATCCCGTTCGACGCCACCTTCCTGGTGTTCAGCGACTACGCGCGTAACGGCGTGCGCATGAGCGCGTTGA
ATCCGGCGCATGCCATCCATGTGTACACGCACGACTCGATCGGCCTGGGCGAAGACGGCCCGACCCATCAGCCGGTCGAA
CACCTGGCCTCGCTGCGCTACATCCCCAACAACGATGTGTGGCGCCCGGGCGATGCGGTGGAGTCGGCGGTGAGCTGGAA
GGCCGCGATCACTCGCAAGGACGGCCCGAGCTGCCTGGTGTTCAGTCGCCAGAATCTGCAGCACCAGCCGCGCAGCGCCG
AGCAGATCAAACTGATCGAACGCGGCGGTTACGTGTTGGCCGATGCCGAAGGCGGCACGCCCGACGTGATCCTGATCGGC
ACCGGCTCGGAAGTGGGCCTGGCAGTGGAAGCGAAGAAGACGCTGGATGCGGCCGGGCTGAAGACACGCGTGGTGTCGAT
GCCGTCCACCGACGTGTTCGATCGCCAGGATGCCGCGTACCGCGAGCAGGTGCTGCCCAATGCCGTGCGCAAGCGCGTGG
CGGTGGAAGCGGGCGTGACCGGCTTCTGGCGCAAGTATGTCGGCCTAGATGGCGATGTGGTCGGTATCGACACCTTCGGT
GCCTCGGCGCCGGCGGATCAGCTGTATGCGTACTTCAAGATCACCGCCGAGCACGTGGTCGAGGCCGCCAAGGCGCTGTA
A

Upstream 100 bases:

>100_bases
CCGTTTCTCCATTCCCGGCTGCTGATTCCCCTAACACGCTCTGTGGGAGAATACGGGTCTCCGCTTCCAGCGGTGTTCCC
CTCCGCTTCCATAGACGCCC

Downstream 100 bases:

>100_bases
TGCGTTGTGGTGTTGATTGAAAAAAGCCGGCGAAAGCCGGCTTTTTTCTTGGGAGGTCTGCGCGATGGGTGATGCTGCGG
GCAGGCAGCATGCACCGCCG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCM
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDNTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENSDKP
TLICCRTKIGFGAPTKSGKESSHGAPLGKEELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
GEQADELTRRSRGELPADFIVQADAYIAKAQEDGQTIASRKASQLAIEAFAPLLPELVGGSADLAHSNLTLWKASKSVAT
DDPNANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLVFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIG
TGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYREQVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFG
ASAPADQLYAYFKITAEHVVEAAKAL

Sequences:

>Translated_666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
GYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCM
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDNTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENSDKP
TLICCRTKIGFGAPTKSGKESSHGAPLGKEELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQY
GEQADELTRRSRGELPADFIVQADAYIAKAQEDGQTIASRKASQLAIEAFAPLLPELVGGSADLAHSNLTLWKASKSVAT
DDPNANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLVFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIG
TGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYREQVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFG
ASAPADQLYAYFKITAEHVVEAAKAL
>Mature_665_residues
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLSG
YDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCMM
EGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDNTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENSDKPT
LICCRTKIGFGAPTKSGKESSHGAPLGKEELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYAKQYG
EQADELTRRSRGELPADFIVQADAYIAKAQEDGQTIASRKASQLAIEAFAPLLPELVGGSADLAHSNLTLWKASKSVATD
DPNANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVEH
LASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLVFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIGT
GSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAYREQVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGA
SAPADQLYAYFKITAEHVVEAAKAL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=598, Percent_Identity=26.5886287625418, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI4507521, Length=598, Percent_Identity=26.5886287625418, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI133778974, Length=584, Percent_Identity=26.541095890411, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI225637459, Length=677, Percent_Identity=22.1565731166913, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=573, Percent_Identity=22.8621291448517, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=573, Percent_Identity=22.8621291448517, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=64.1993957703928, Blast_Score=886, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=61.3050075872534, Blast_Score=842, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=26.1515601783061, Blast_Score=171, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325331, Length=676, Percent_Identity=46.5976331360947, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=43.2634730538922, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=680, Percent_Identity=26.0294117647059, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI45550715, Length=680, Percent_Identity=26.0294117647059, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24666278, Length=585, Percent_Identity=25.1282051282051, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=25.5417956656347, Blast_Score=140, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72635; Mature: 72504

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCMMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHCCCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDNTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENSDKP
EEEECCCEEEECCCCCCCCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
TLICCRTKIGFGAPTKSGKESSHGAPLGKEELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYGEQADELTRRSRGELPADFIVQADAYIAKAQEDGQTIASR
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHEEECCHHHHHCHHCCHHHHHH
KASQLAIEAFAPLLPELVGGSADLAHSNLTLWKASKSVATDDPNANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCCEEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLVFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAEGGTPDVILIGTGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCEEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
REQVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGASAPADQLYAYFKITAEHVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHEEEEHHHHH
EAAKAL
HHHHCC
>Mature Secondary Structure 
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSGYDLPIEQLKQFRQLHSKTAGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCMMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHCCCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDNTPARFEAYGWHVIRDVDGHDADKIKAAIEAALENSDKP
EEEECCCEEEECCCCCCCCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCC
TLICCRTKIGFGAPTKSGKESSHGAPLGKEELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYAKQYGEQADELTRRSRGELPADFIVQADAYIAKAQEDGQTIASR
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHEEECCHHHHHCHHCCHHHHHH
KASQLAIEAFAPLLPELVGGSADLAHSNLTLWKASKSVATDDPNANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPAHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCCEEEEEEHHHCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRKDGPSCLVFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAEGGTPDVILIGTGSEVGLAVEAKKTLDAAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCEEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
REQVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGASAPADQLYAYFKITAEHVV
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHEEEEHHHHH
EAAKAL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]