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The map label for this gene is gltP [H]

Identifier: 66767262

GI number: 66767262

Start: 1115651

End: 1116955

Strand: Reverse

Name: gltP [H]

Synonym: XC_0930

Alternate gene names: 66767262

Gene position: 1116955-1115651 (Counterclockwise)

Preceding gene: 66767263

Following gene: 66767261

Centisome position: 21.69

GC content: 64.06

Gene sequence:

>1305_bases
GTGTCCAGACCAAGGCCTGTCCCGATGACCGCATCCCCAGCCGCGCGCCGCCCAGGCCTGCCCCTGCATTGGAAGATGGG
CATTGGCTTCGCCATCGGCCTGGTGCTGGGTCTGGCCGTGTACTACCTGGCCGGGAGCGACGCCGAATGGGTGCGGCTGG
TGACCAAGTACGTCACCACGCCGTTCTCGCAGATCTTCCTCAATCTGATCTTCATGCTGATCGTGCCGCTGCTGTTTTCG
GCGCTGGTGGTCGGCATTGCGGAAATGGGCGACATCCGCGCGTTGGGCCGGGTGGGCTGGCGCACGCTGGGCTACACGGT
GGTGTTGTCGGGCATTGCGGTGTTGCTGGGCTTGGTCCTGGTCAATGTGCTCAAGCCCGGTGCAGGCGTGGACCCGCAAC
TGGCCAACCAGTTGATCCAGGAAAATGCCGACCGCACCCGCGAGATCATCTCCAGCTCCGGCAATCAGCCGCAGGGCATG
GACATGCTGCTTTCCATCGTGCCGAACAACGTGATTGCGGCGGCCTCGAGCAATGGCGCGATCCTGTCGTTGATGTTCTT
CGCGGTGATGTTCGGCGTGGGCATGGTGCTCACGGCCGACGAAAAAGTGGCCACGCTCAAGCGCGGCATTGAAGGCATCT
TCGAGATCTCGATGACCCTGATCGGGCTGGTGATCCGCCTGGCGCCGTACGCGGTGGCCTGTTTCATGTTCAATCTGGCC
GCGTTGTTCGGCTTCGATCTGCTGATTCGCCTGGGCGCCTACGTCGGCGTCGTGGTGCTGGCGCTGGGCCTGCACATGGT
GGTCAGCTACGGGCTGGCGGTGAAGTTCGCCGGGCGTTCGCCGATCGGCTTCTTCCGGCAGACGCAGGAGGCCACGCTGA
TGGCGTTCTCCACCGCCTCCAGCAACGCGACCCTGCCAACCGCCTTGCGCGTGGCCGACGAGATGGGCCTGCCACCGCGG
GTCTCGCGCTTCGTGCTCACCGTGGGCGCCACCGCCAACCAGAACGGCACCGCGCTGTTCGAAGGCGTGACGGTGATCTT
CCTGGCGCAGTTCTTCAATGTGGACCTGAGAATCGGCCAGCAATTCATGGTGATGATCGTCTGCATCCTGGGTGGCATCG
GCACCGCCGGTGTGCCCTCCGGCTCGCTGCCGGTAGTAGCGCTGATCTGCGCGATGGTTGGGGTCAACCCGGTCGGCATC
GGCATGATCCTGGGCGTCAATCACTTCCTGGACATGTGCCGTACCGCGCTGAATGTCACCGGCGATCTGGCGTTGACGAC
GCTGGTGGCTAAGGGGGAGAAGTAG

Upstream 100 bases:

>100_bases
CAGCACATGGTGTCGAGAGGCGGGCCTACCCTAAGGATGCGCGCATGGGGCGCCTTGGGTAGGTGGCCGCGCCGGTGGTG
TTTGTTAAGCTCCGGCCTTT

Downstream 100 bases:

>100_bases
GGAATCGGGAATCAGGAATCGTTAGAGCGGGCTGTTGCGATCGGGGCGCGTACTGCGAAGTCCTGCGCATCGCAGCGGTA
GCGGTGGTGTGAGTGGCGTT

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSRPRPVPMTASPAARRPGLPLHWKMGIGFAIGLVLGLAVYYLAGSDAEWVRLVTKYVTTPFSQIFLNLIFMLIVPLLFS
ALVVGIAEMGDIRALGRVGWRTLGYTVVLSGIAVLLGLVLVNVLKPGAGVDPQLANQLIQENADRTREIISSSGNQPQGM
DMLLSIVPNNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLKRGIEGIFEISMTLIGLVIRLAPYAVACFMFNLA
ALFGFDLLIRLGAYVGVVVLALGLHMVVSYGLAVKFAGRSPIGFFRQTQEATLMAFSTASSNATLPTALRVADEMGLPPR
VSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLRIGQQFMVMIVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGI
GMILGVNHFLDMCRTALNVTGDLALTTLVAKGEK

Sequences:

>Translated_434_residues
MSRPRPVPMTASPAARRPGLPLHWKMGIGFAIGLVLGLAVYYLAGSDAEWVRLVTKYVTTPFSQIFLNLIFMLIVPLLFS
ALVVGIAEMGDIRALGRVGWRTLGYTVVLSGIAVLLGLVLVNVLKPGAGVDPQLANQLIQENADRTREIISSSGNQPQGM
DMLLSIVPNNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLKRGIEGIFEISMTLIGLVIRLAPYAVACFMFNLA
ALFGFDLLIRLGAYVGVVVLALGLHMVVSYGLAVKFAGRSPIGFFRQTQEATLMAFSTASSNATLPTALRVADEMGLPPR
VSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLRIGQQFMVMIVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGI
GMILGVNHFLDMCRTALNVTGDLALTTLVAKGEK
>Mature_433_residues
SRPRPVPMTASPAARRPGLPLHWKMGIGFAIGLVLGLAVYYLAGSDAEWVRLVTKYVTTPFSQIFLNLIFMLIVPLLFSA
LVVGIAEMGDIRALGRVGWRTLGYTVVLSGIAVLLGLVLVNVLKPGAGVDPQLANQLIQENADRTREIISSSGNQPQGMD
MLLSIVPNNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLKRGIEGIFEISMTLIGLVIRLAPYAVACFMFNLAA
LFGFDLLIRLGAYVGVVVLALGLHMVVSYGLAVKFAGRSPIGFFRQTQEATLMAFSTASSNATLPTALRVADEMGLPPRV
SRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLRIGQQFMVMIVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIG
MILGVNHFLDMCRTALNVTGDLALTTLVAKGEK

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=438, Percent_Identity=29.6803652968037, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=29.2565947242206, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI66773030, Length=447, Percent_Identity=27.7404921700224, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21314632, Length=409, Percent_Identity=27.6283618581907, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI194239697, Length=415, Percent_Identity=26.7469879518072, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI169790839, Length=413, Percent_Identity=27.8450363196126, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=28.7206266318538, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=36.986301369863, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=30.2788844621514, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=30.2788844621514, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI262359914, Length=351, Percent_Identity=26.7806267806268, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790514, Length=418, Percent_Identity=34.688995215311, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789947, Length=379, Percent_Identity=31.6622691292876, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788024, Length=412, Percent_Identity=25.2427184466019, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17537407, Length=401, Percent_Identity=29.925187032419, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=28.5077951002227, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=399, Percent_Identity=31.077694235589, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=412, Percent_Identity=28.1553398058252, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983106, Length=412, Percent_Identity=28.1553398058252, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=28.7841191066998, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=25.3101736972705, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=431, Percent_Identity=30.3944315545244, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI17137668, Length=431, Percent_Identity=30.3944315545244, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24583023, Length=431, Percent_Identity=30.3944315545244, Blast_Score=152, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281360481, Length=426, Percent_Identity=23.7089201877934, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360483, Length=426, Percent_Identity=23.7089201877934, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137666, Length=426, Percent_Identity=23.7089201877934, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45878; Mature: 45747

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHCCCC
>Mature Secondary Structure 
SRPRPVPMTASPAARRPGLPLHWKMGIGFAIGLVLGLAVYYLAGSDAEWVRLVTKYVTT
CCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
PFSQIFLNLIFMLIVPLLFSALVVGIAEMGDIRALGRVGWRTLGYTVVLSGIAVLLGLVL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNVLKPGAGVDPQLANQLIQENADRTREIISSSGNQPQGMDMLLSIVPNNVIAAASSNGA
HHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCH
ILSLMFFAVMFGVGMVLTADEKVATLKRGIEGIFEISMTLIGLVIRLAPYAVACFMFNLA
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFGFDLLIRLGAYVGVVVLALGLHMVVSYGLAVKFAGRSPIGFFRQTQEATLMAFSTAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCHHHEEEEEECC
SNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLRIGQ
CCCCCHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
QFMVMIVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDMCRTALNVT
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
GDLALTTLVAKGEK
CHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]