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The map label for this gene is tdcB [H]

Identifier: 66767171

GI number: 66767171

Start: 1008799

End: 1009974

Strand: Reverse

Name: tdcB [H]

Synonym: XC_0838

Alternate gene names: 66767171

Gene position: 1009974-1008799 (Counterclockwise)

Preceding gene: 66767172

Following gene: 66767170

Centisome position: 19.62

GC content: 67.01

Gene sequence:

>1176_bases
ATGACCAGATGGCTGTTCGGAGGTGTCTTCTTCCGGATCGGCCGCGCGCGTGCCGCAATGCCTGATTCCGGCCGCCCGAC
CACGCAGGAGCCAGACGTAGGCGAGGTCGCCGTCAGCGTGGCCGACGTGCTGGCCGCGCAGGCACGCCTGCGCAAGTACC
TATCGCCCACACCACTGCATTACGCCGAACGCTTCGGCGTGTGGCTGAAGCTGGAAAATCTGCAGCGCACCGGCTCCTAC
AAGGTACGTGGCGCATTGAATGCGCTGCTGGCCGGACTGGAGCGCGGCGATGAGCGCCCGGTCATCTGCGCCTCGGCCGG
CAACCATGCTCAGGGCGTGGCGTGGTCGGCGTATCGGTTGGGCGTGCAGGCCATCACGGTGATGCCGCACGGTGCGCCGC
AGACCAAGATCGCCGGCGTGGCCCACTGGGGCGCCACGGTGCGCCAGCACGGCAACAGTTACGACGAAGCCTTCGCCTTT
GCGCGCGAGCTGGCCGACCAGAACGGCTATCGCTTTCTGTCTGCGTTCGACGACCCGGATGTGATCGCCGGACAAGGCAC
GGTGGGTATCGAGTTGGCCGCGCATGCACCGGATGTGGTGATCGTGCCGATCGGCGGCGGTGGCCTGGCCTCCGGCGTGG
CGTTGGCGCTGAAGTCGCAGGGCGTACGCATCGTCGGCGCGCAGGTGGAAGGCGTGGACTCCATGGCCCGCGCCGTGCGC
GGCGACCTGCGCGAAATCACCCCGGTCGCCACCCTGGCCGATGGCGTGAAGGTCAAGATTCCCGGCTTCCTGACCCGTCG
TCTGTGCTCGAGCCTGCTCGACGACGTGGTGATCGTGCGCGAGGCCGAATTGCGCGAGACGCTGGTGCGTCTGGCACTGG
AAGAGCACGTCATTGCCGAAGGCGCCGGCGCACTCGCGCTGGCCGCCGGTCGCCGTGTTTCCGGCAAACGTAAATGTGCG
GTGGTCTCTGGCGGTAATATCGACGCGACTGTCCTGGCCACCCTGTTATCCGAGGTGCGGCCGCGTCCGCCACGCAAGCC
GCGCCGTCGCAATACCGAGCGGCTCCGCAACGAACGCAGCACCAAAGCATCACCGCCATCCATTGCTATTCCCCGCCCAT
CCGCAGTCGCATCAACGCCTGTCACCGCCATCGCAGTAGAGGAGTCTTCCTGGTGA

Upstream 100 bases:

>100_bases
GCTGCGCCTGCAGTTGGAAAAAGTGTACGACTGCGAGTCGGTGGCGATCACGGCCTTGGACTCGGTGGAGGCCGCCGCAT
GAGCCTGCAGACCTCGCGGG

Downstream 100 bases:

>100_bases
ACACGACCGTATCCAACCAGACCCCGCATATCCGAATTTTCGACACCACCCTGCGCGACGGCGAGCAATCCCCCGGCTGC
AGCATGACGCCCCAACAAAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTRWLFGGVFFRIGRARAAMPDSGRPTTQEPDVGEVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSY
KVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAFAF
ARELADQNGYRFLSAFDDPDVIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRIVGAQVEGVDSMARAVR
GDLREITPVATLADGVKVKIPGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAAGRRVSGKRKCA
VVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERSTKASPPSIAIPRPSAVASTPVTAIAVEESSW

Sequences:

>Translated_391_residues
MTRWLFGGVFFRIGRARAAMPDSGRPTTQEPDVGEVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSY
KVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAFAF
ARELADQNGYRFLSAFDDPDVIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRIVGAQVEGVDSMARAVR
GDLREITPVATLADGVKVKIPGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAAGRRVSGKRKCA
VVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERSTKASPPSIAIPRPSAVASTPVTAIAVEESSW
>Mature_390_residues
TRWLFGGVFFRIGRARAAMPDSGRPTTQEPDVGEVAVSVADVLAAQARLRKYLSPTPLHYAERFGVWLKLENLQRTGSYK
VRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRLGVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAFAFA
RELADQNGYRFLSAFDDPDVIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRIVGAQVEGVDSMARAVRG
DLREITPVATLADGVKVKIPGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAEGAGALALAAGRRVSGKRKCAV
VSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERSTKASPPSIAIPRPSAVASTPVTAIAVEESSW

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=320, Percent_Identity=30.3125, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI33469958, Length=127, Percent_Identity=36.2204724409449, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=40.5144694533762, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1790207, Length=291, Percent_Identity=40.5498281786942, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=27.0547945205479, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=35.6913183279743, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=27.5316455696203, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17537387, Length=278, Percent_Identity=34.8920863309352, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=35.6687898089172, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320930, Length=255, Percent_Identity=35.6862745098039, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=36.3057324840764, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24645328, Length=220, Percent_Identity=36.3636363636364, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 41554; Mature: 41423

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRWLFGGVFFRIGRARAAMPDSGRPTTQEPDVGEVAVSVADVLAAQARLRKYLSPTPLH
CCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YAERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRL
HHHHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHH
GVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDPD
CEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
VIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRIVGAQVEGVDSMARAVR
EEECCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
GDLREITPVATLADGVKVKIPGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAE
HHHHHHCHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGALALAAGRRVSGKRKCAVVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERS
CCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHCC
TKASPPSIAIPRPSAVASTPVTAIAVEESSW
CCCCCCCEECCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
TRWLFGGVFFRIGRARAAMPDSGRPTTQEPDVGEVAVSVADVLAAQARLRKYLSPTPLH
CCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YAERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDERPVICASAGNHAQGVAWSAYRL
HHHHCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHH
GVQAITVMPHGAPQTKIAGVAHWGATVRQHGNSYDEAFAFARELADQNGYRFLSAFDDPD
CEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
VIAGQGTVGIELAAHAPDVVIVPIGGGGLASGVALALKSQGVRIVGAQVEGVDSMARAVR
EEECCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
GDLREITPVATLADGVKVKIPGFLTRRLCSSLLDDVVIVREAELRETLVRLALEEHVIAE
HHHHHHCHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGALALAAGRRVSGKRKCAVVSGGNIDATVLATLLSEVRPRPPRKPRRRNTERLRNERS
CCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHCC
TKASPPSIAIPRPSAVASTPVTAIAVEESSW
CCCCCCCEECCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]