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The map label for this gene is ywrD [H]

Identifier: 66766645

GI number: 66766645

Start: 356337

End: 357917

Strand: Reverse

Name: ywrD [H]

Synonym: XC_0301

Alternate gene names: 66766645

Gene position: 357917-356337 (Counterclockwise)

Preceding gene: 66766646

Following gene: 66766641

Centisome position: 6.95

GC content: 69.89

Gene sequence:

>1581_bases
ATGCTGCACACCTTGCGCGCACGCCGCGGCATGGTGGTCGCGCCTCACCATCTGGCCGCGCAGGCCGGGCGCGACATCCT
GCGCGCCGGCGGCAACGCCATCGAAGCAGCGGTGGCCACCGCCGCCTGTCTGGCCGTGGTGTATCCGCACATGACCGGCA
TCGGCGGCGATGGCTTCTGGCTGATCCACGAACCCGATGGCCGCGTACACGCCATCGACGCCTGCGGCCGTGCCGCACAG
GCGGCCACGCTGGACTTCTATCGCGGCCACACCCACATCCCCTGGCGCGGCCCGGGCGCCGCCAATACCGTGGCCGGCAC
CGTCTCCGGCTGGGCGCTTGCGCTCCAGCACGGTGGTGGCACGCTCCCGCTGCAGCAGCTGCTGGAAGAGGCCATCCACC
ATGCCGAGGTGGGCGTGCCGATCACGCTCGGCGGTGCGCACATCGCCGCCAGCAAGGGCGATGAACTGCGTTGCCTGCCG
GGCGCCTATGCGCGCATCTTCGAGCCGCGCGGCGCGCCCCTGCACGAGGGCGCCGTGCTGCAGCAACCCCAGCTCGCGCG
CACCCTGCAACGGCTGGCGCACGATGGCCTGGACAGTTTCTACCGCGGCGCGCTCGCCGATGACATCGCCGCCGACCTAC
GCGTACTCGGCAGCCCGTTGCATGCGGATGACCTGGCCACACACACCGCCGAGGCCAGCGTGCCGCTCTCAGTCGCCATC
GCCGGTGCACGTTTGTATAACCACGCACCGCCCACGCAAGGGCTGGCCTCGCTGTTGATCCTGGCGCTGTTCGACCGCCT
GCCGGCCACGCAGGCAGACAGTTTCGCGCACCTGCATGGCCTGATCGAAGCCACCAAACAGGCCTTCCTGATTCGCGACG
CCCACATCGGCGACAGCGCCTGGATGACGCTCGACGCACAAGCCCTGCTCGACGACAGCGCTGCGCTGGACGCACTGGCC
GCCCGCATCGACCTGCACGCGGCCCTGCCCTGGCCGCAGCCCTCGCAGGCCGGCGACACCGTCTGGTTCGGCGCCATCGA
CGCGCAGGGCCGCGCGGTGAGCTGCATCCAGTCCACCTATTTCGAATTCGGCTCCGGCCTGGTGCTGCCGCATACCGGCA
TCACCTGGCAGAATCGCGGCTGCAGCTTTCGCCTCGCCACCGACGGCTGGAATGCACTCGCCCCAGGGCGTAAACCGTTC
CACACCCTCAACCCCGCCCTGGCCACCTTCGACGATGGCCGCGTCATGGCCTACGGCACCATGGGCGGCGAAGGCCAACC
GCAGACCCAGGCCGCGCTGTTCTCGCGCTACGCCCACTTCGGCATGCCGTTGCAACAGGCCATCACCGCACCGCGCTGGC
TGCTCGGCCGCACCTGGGGCGACGACAGCACCACGTTGAAGCTGGAAGACCGCTTCGACCCGGCCGTGGTGCAAGCACTG
CGCGACGCCGGCCACGCCGTCGAACTGTTACCGGCCTATAGCTCGGTGATGGGGCATGCTGGCGCCCTGGTGCGTGAGGT
CACCGGCGTGGTGAGTGGTGCGAGCGACCCAAGATCGGATGGTGCGGTGGCTGGGTGGTGA

Upstream 100 bases:

>100_bases
TGATTGCCGCGCCAGGCCGCGAAGACCGCCTGTTCGCTCTGGCCGCGCAACTCGAACGCGATGGGCTGCTCGCGTTCAGC
GCACCGGCGGAGACACGCTG

Downstream 100 bases:

>100_bases
GGGTTGGGTGCGACCTCTCGTGCCTGCGTCATCAAACGTTACAAGCGCTCACGCAAGACCTCTGCGAAGGCATGGTTGCG
TACCAGCACGTTCGCCTCCA

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MLHTLRARRGMVVAPHHLAAQAGRDILRAGGNAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHTHIPWRGPGAANTVAGTVSGWALALQHGGGTLPLQQLLEEAIHHAEVGVPITLGGAHIAASKGDELRCLP
GAYARIFEPRGAPLHEGAVLQQPQLARTLQRLAHDGLDSFYRGALADDIAADLRVLGSPLHADDLATHTAEASVPLSVAI
AGARLYNHAPPTQGLASLLILALFDRLPATQADSFAHLHGLIEATKQAFLIRDAHIGDSAWMTLDAQALLDDSAALDALA
ARIDLHAALPWPQPSQAGDTVWFGAIDAQGRAVSCIQSTYFEFGSGLVLPHTGITWQNRGCSFRLATDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAALFSRYAHFGMPLQQAITAPRWLLGRTWGDDSTTLKLEDRFDPAVVQAL
RDAGHAVELLPAYSSVMGHAGALVREVTGVVSGASDPRSDGAVAGW

Sequences:

>Translated_526_residues
MLHTLRARRGMVVAPHHLAAQAGRDILRAGGNAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHTHIPWRGPGAANTVAGTVSGWALALQHGGGTLPLQQLLEEAIHHAEVGVPITLGGAHIAASKGDELRCLP
GAYARIFEPRGAPLHEGAVLQQPQLARTLQRLAHDGLDSFYRGALADDIAADLRVLGSPLHADDLATHTAEASVPLSVAI
AGARLYNHAPPTQGLASLLILALFDRLPATQADSFAHLHGLIEATKQAFLIRDAHIGDSAWMTLDAQALLDDSAALDALA
ARIDLHAALPWPQPSQAGDTVWFGAIDAQGRAVSCIQSTYFEFGSGLVLPHTGITWQNRGCSFRLATDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAALFSRYAHFGMPLQQAITAPRWLLGRTWGDDSTTLKLEDRFDPAVVQAL
RDAGHAVELLPAYSSVMGHAGALVREVTGVVSGASDPRSDGAVAGW
>Mature_526_residues
MLHTLRARRGMVVAPHHLAAQAGRDILRAGGNAIEAAVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHTHIPWRGPGAANTVAGTVSGWALALQHGGGTLPLQQLLEEAIHHAEVGVPITLGGAHIAASKGDELRCLP
GAYARIFEPRGAPLHEGAVLQQPQLARTLQRLAHDGLDSFYRGALADDIAADLRVLGSPLHADDLATHTAEASVPLSVAI
AGARLYNHAPPTQGLASLLILALFDRLPATQADSFAHLHGLIEATKQAFLIRDAHIGDSAWMTLDAQALLDDSAALDALA
ARIDLHAALPWPQPSQAGDTVWFGAIDAQGRAVSCIQSTYFEFGSGLVLPHTGITWQNRGCSFRLATDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAALFSRYAHFGMPLQQAITAPRWLLGRTWGDDSTTLKLEDRFDPAVVQAL
RDAGHAVELLPAYSSVMGHAGALVREVTGVVSGASDPRSDGAVAGW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=547, Percent_Identity=28.3363802559415, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915090, Length=547, Percent_Identity=28.3363802559415, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915096, Length=547, Percent_Identity=28.3363802559415, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI73915094, Length=547, Percent_Identity=28.3363802559415, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI113429324, Length=532, Percent_Identity=28.3834586466165, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI113429326, Length=540, Percent_Identity=28.1481481481481, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI109148539, Length=545, Percent_Identity=25.6880733944954, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI153266901, Length=572, Percent_Identity=23.7762237762238, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI153266885, Length=571, Percent_Identity=23.9929947460595, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789856, Length=552, Percent_Identity=29.8913043478261, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI212646519, Length=502, Percent_Identity=24.5019920318725, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI72000294, Length=502, Percent_Identity=24.5019920318725, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=486, Percent_Identity=25.9259259259259, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193208245, Length=486, Percent_Identity=25.9259259259259, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=522, Percent_Identity=24.5210727969349, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17542894, Length=479, Percent_Identity=24.8434237995825, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24642670, Length=560, Percent_Identity=26.7857142857143, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642666, Length=560, Percent_Identity=26.7857142857143, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161077878, Length=560, Percent_Identity=26.7857142857143, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=26.4478764478764, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551474, Length=560, Percent_Identity=26.7857142857143, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161077880, Length=560, Percent_Identity=26.7857142857143, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18859741, Length=550, Percent_Identity=23.4545454545455, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077496, Length=459, Percent_Identity=21.7864923747277, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55454; Mature: 55454

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTLRARRGMVVAPHHLAAQAGRDILRAGGNAIEAAVATAACLAVVYPHMTGIGGDGFW
CCCCCHHCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHTHIPWRGPGAANTVAGTVSGWALALQHGGG
EEECCCCCEEEEHHHCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHCCCCEEEEEECCCC
TLPLQQLLEEAIHHAEVGVPITLGGAHIAASKGDELRCLPGAYARIFEPRGAPLHEGAVL
CCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCCCEEECCCHHHHHCCCCCCCCCCCCCC
QQPQLARTLQRLAHDGLDSFYRGALADDIAADLRVLGSPLHADDLATHTAEASVPLSVAI
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEE
AGARLYNHAPPTQGLASLLILALFDRLPATQADSFAHLHGLIEATKQAFLIRDAHIGDSA
EHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCE
WMTLDAQALLDDSAALDALAARIDLHAALPWPQPSQAGDTVWFGAIDAQGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
FEFGSGLVLPHTGITWQNRGCSFRLATDGWNALAPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCEECCCCCEEEEECCCCCCCCCCCCCCHHCCCCCEEECCCEEEEEEC
MGGEGQPQTQAALFSRYAHFGMPLQQAITAPRWLLGRTWGDDSTTLKLEDRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RDAGHAVELLPAYSSVMGHAGALVREVTGVVSGASDPRSDGAVAGW
HHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLHTLRARRGMVVAPHHLAAQAGRDILRAGGNAIEAAVATAACLAVVYPHMTGIGGDGFW
CCCCCHHCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHTHIPWRGPGAANTVAGTVSGWALALQHGGG
EEECCCCCEEEEHHHCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHCCCCEEEEEECCCC
TLPLQQLLEEAIHHAEVGVPITLGGAHIAASKGDELRCLPGAYARIFEPRGAPLHEGAVL
CCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCCCEEECCCHHHHHCCCCCCCCCCCCCC
QQPQLARTLQRLAHDGLDSFYRGALADDIAADLRVLGSPLHADDLATHTAEASVPLSVAI
CCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEE
AGARLYNHAPPTQGLASLLILALFDRLPATQADSFAHLHGLIEATKQAFLIRDAHIGDSA
EHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCE
WMTLDAQALLDDSAALDALAARIDLHAALPWPQPSQAGDTVWFGAIDAQGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHH
FEFGSGLVLPHTGITWQNRGCSFRLATDGWNALAPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCEECCCCCEEEEECCCCCCCCCCCCCCHHCCCCCEEECCCEEEEEEC
MGGEGQPQTQAALFSRYAHFGMPLQQAITAPRWLLGRTWGDDSTTLKLEDRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RDAGHAVELLPAYSSVMGHAGALVREVTGVVSGASDPRSDGAVAGW
HHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]