Click here to switch to the map view.

The map label for this gene is lgrD [H]

Identifier: 66048235

GI number: 66048235

Start: 5943655

End: 5947101

Strand: Direct

Name: lgrD [H]

Synonym: Psyr_5011

Alternate gene names: 66048235

Gene position: 5943655-5947101 (Clockwise)

Preceding gene: 66048234

Following gene: 66048236

Centisome position: 97.54

GC content: 59.85

Gene sequence:

>3447_bases
ATGAAGCGCCTGGAGATTGTGCTCATCGGTCACAGCCTGACCTTGAGTGAACTGAATAGCGAGCTGCTGGACCACGGGCA
TGGCGTGCGGCATCTGTCTGATCAGCAGGCGCTGGACGCGTTGACGGTGCCTGATGGCGGCGTGCTGATCGAAGACGGCA
GCCTGGACCTGTCCGAGGAACAACTGAATGCGTTCGGCCACTGCACGCAACTGCGACTGCGGGTCGGTTTCAGCAAGGCG
CTGGATCACGGATTACCCCGGCTGGAATTGCTGTGCTGGCATGGCGCAGCCGAGGCTCGACGTTTGATCGTTCATAAGTG
GCTTGCGGTCGAGGAATCAGGCAACGGGCGGGTACTGCGTGATGCCGCTGTCGCAGCCATGGTGGATCTGGCGACATTGC
AGATCAGCCGGTTATCCAGAGATGAAGACTGTCTCAACGGTATGACAAGCGTCACACCCGCCCGGAGCGATCGGCAGCAC
GGCTTGCAGGCGGTTGATCAATTGCTGTTCGAGCATCGTTTCAATCAGACAGATCAACCGCATCTGCTGAAACTGTCCGA
AACACCCATCACCGAGCGGCTGGAGCAGGCGCTGCTGACGTTTGCCGAACGCCCGGCACTGTCCGTTCGCAACCGGACGC
TCAGCTATCGGCAACTGCACGCGCACAGTCTCGCCATCCAAAGCTTGCTGCAGCCGTTGCTGGCGCACGCGAAAGCCGGC
ACACCTGCCGTGATCGGTATCTGCCTGCACAAGTCAGCCGAGCTGTATGCGGGCATTCTCGCGGTTCTGGGTTGCGGTGC
GGTTTACCTGCCACTTGATCCCGGCCAGCCCGTGCAGCGTCAGCAGTACATTCTGGAAAACTCGGGAGCGATGCTGTTGC
TGCACGATGGCTCGCACCCGCTGGCGGCTGCGGAGTTTCCGGCGCTGGATATCGCTACGGTTCCTGTGGGAGATGGAGCT
CCAACCCATGTACGCGTTGCTACCGATCAGGATGCGCCCTGCATGGCGCTGTACACGTCGGGCACCACGGGACAGCCGAA
AGGCGTATTGCTCAGCCAGCGCAATCTCAGCCACTTCACCGCCTGGTATGCCGAGCATGTGAGCCTGAGTGAACACAGCC
GGGTGCTGCAATTCTCTACGCTGAGTTTCGACTCATCGATTATCGACATTTTCCCCACCTGGCTCAGTGGCGCCGAGCTG
GTGGTCCCCGATGAAGACCAGCGACGTGATCCGTTGCAGTTGGTCAGCGCGCTGCAACAAGGCATCACCCATGCATTCCT
GCCGCCGGCGCTGTTGAGCATCCTGCCGCTGGATCAACCGCTGGGGCTTGAGCATGTCATGACCGGAGGCGACGTCTGTG
AGCCGCACGTGATTGCGCAACTCACCAGGCAATGTCATTTCCACAACCTGTACGGCCCCACCGAGGCCACGGTGTTGGTC
ACCGCCTGCGAGTTCGGGCCGTCCAGCAGCAACCGACATCTGGGCCGACCGATCGCCAACAGCCAGGCGTGGATTCTGGA
CGAGCAATTGCAGCCCGTGGCCGAACAGACTCAGGGTGAGCTGTACATCATCGGTCCCGGCGTCTGTCTGGGCTATGTAA
ACAATCCCGCGCTTACCGCCGAGCGCTATGTGTGGCTGACGAAGCCGGATGGCCAGCTTATGCGTGCCTATCGCACCGGC
GACATCGCCAAGTGGACGGCTGACGGCATCGTCCTCAGCGGTCGTCGTGATAATCAGGTGAAGATTCGCGGCTTTCGGGT
CGAGCCGGAAGAGATCGAGCATTGCCTGCGTGACAGCGGACTGTATCGACAGGTTGCCGTGGTGATCGACAGACAGCGGC
GAATTCTGGCGTTTCTCGCTCAACCGTACCTTGAGCATGACGAACAGGCACTGAAAGCGCATGTACAGCGCCTGCTGCCT
GATTACATGCATCCCGCTGTCTACACGCTGTTGCCCGGCATGCCATTCGCCAGTAACGGCAAGGTCGATCGCAAAGCGCT
TCTGGAAATCCCGCTGAGCTTTACCGGGCAGCACACTCGTCGGCTGCCCGAGACTGAGCAGCAACAGGCGCTGCTGGGGC
TATGGAGCGAGCTGCTGGAGCTGCCGCCAGACGATATCTCGACTGATGACAGCTTTTTCAATCTCGGTGGTCACTCGATC
CTGCTGTCGCGGCTGTTGCTGGGGGTTCGCGAACGCTTTGGGCGCAGCATTCCGATCAATCGCTTTATCGAAGCACCGAC
GGTGCTGACACTGGCCAGCCTGATCGACAGCGACGGCACCTCGGCGGGCGTCCTCAGTGCTCAGGCCCTGCGGGATGCCA
ACCCGGACTTTCAGCTGGCTACATTGCCCGTCAGCAGGCTGGGTGATGTTCATAAAGTGATTGTCACGGGTGCCAATGGC
TTTCTGGGTGTGCATATCGTCGAAGCGCTGCTCAACCGGGGGGCGACCGAGATCGCCTGCCTGGTGCGCGAGGCTGCTGG
ACAAAGCGCGCAGCAGCGTTTCGAGGATGCCCTGCGGGAAAACCGTCTGGACCACCTGGACCTGAGTCGCGTGCAGGTCT
ACCCCGCTGACCTGACAAAGCCTCGGTTGGGGCTCAGTGAAGCGGTGTATGAGCGGCTGGATCTCGAGTTTGGTGCGTTG
GTGCACAACGCTGCCAATGTGAACCATGTTCAGGACTATGAAAGCCTGGTCAAAGACAATGTCGCCCCGGTCTTTGAATG
CCTCAAGCTGTGTGAAGGGCGCAGTAAAAAGATCTTCAATTTCGTGTCGACGTTGTCTGCCTGCAGTGCCATCGATGCCG
CCGGTAATGTGCTTGAACAGCCCGCTGCCACGACCCCGCCGATCTACATCAAGAATGGCTACAACCTCTCCAAATGGGTG
GCTGAGCGCATCCTGCAATGTGCCCGGGACCAAGGTGTGTGGGTGAACATCTATCGCCCCGGCAACATCGCCTTCAACAG
CGTTACCGGCGTGTGTCAGCCACAGAAAAACCGCTTGATGCTGATGCTCAAGGGTTCGCTGCAACTGGGTCAGGTTCCGG
CATTCGCCATTAACTTCGACCTGATGCCGGTGGACTTTCTGGCGCGTTTCATCGGCTTCCATGCCAGCCGTTACCAGCCA
GAACACGCGGTGTTCAACCTGCATAACCCCGAGCCCTTGAGCTGGGGCGACTACGTGCACGCCTTCCGCGAGGCAGGGCG
TCAGTTCGAGCTGGTCAGCGTCGAGCAATGGCAGATGCAACTCAGGCGCGTCGACAGCCAGAACGCGCTGTTTGGCGTGC
TGGGGTTCTATCTGGACGGGTTTGAAGAAGACATCGGCGATATCTCGATGATCGAGCACCGCAACACCCTGAACGGCATT
CGTCGCATGGGCGAGCAATACCCGCAAAAGACTCCGGCGTTGCTGCGCAGGGGCTGCGAATACCTGAAAGAAATCGACTT
CATCTGA

Upstream 100 bases:

>100_bases
TGGCCAACATCGTGCGTTTCTTCAAGAACAGCTCGATGCTGGACGATCCTTGTGTGCAGCGGGCGCTGACGGACTATCTG
CCTGCGCAGAGGGCGCTGCA

Downstream 100 bases:

>100_bases
GCCACTACCCCCTGAGATAAATGGAGAACGACATGAACACACTTCACAGCAATCTGAAACCCGACACCCTTATCAAGAAC
CCGGTGGCGTGCCGAGTGGT

Product: amino acid adenylation:thioester reductase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1148; Mature: 1148

Protein sequence:

>1148_residues
MKRLEIVLIGHSLTLSELNSELLDHGHGVRHLSDQQALDALTVPDGGVLIEDGSLDLSEEQLNAFGHCTQLRLRVGFSKA
LDHGLPRLELLCWHGAAEARRLIVHKWLAVEESGNGRVLRDAAVAAMVDLATLQISRLSRDEDCLNGMTSVTPARSDRQH
GLQAVDQLLFEHRFNQTDQPHLLKLSETPITERLEQALLTFAERPALSVRNRTLSYRQLHAHSLAIQSLLQPLLAHAKAG
TPAVIGICLHKSAELYAGILAVLGCGAVYLPLDPGQPVQRQQYILENSGAMLLLHDGSHPLAAAEFPALDIATVPVGDGA
PTHVRVATDQDAPCMALYTSGTTGQPKGVLLSQRNLSHFTAWYAEHVSLSEHSRVLQFSTLSFDSSIIDIFPTWLSGAEL
VVPDEDQRRDPLQLVSALQQGITHAFLPPALLSILPLDQPLGLEHVMTGGDVCEPHVIAQLTRQCHFHNLYGPTEATVLV
TACEFGPSSSNRHLGRPIANSQAWILDEQLQPVAEQTQGELYIIGPGVCLGYVNNPALTAERYVWLTKPDGQLMRAYRTG
DIAKWTADGIVLSGRRDNQVKIRGFRVEPEEIEHCLRDSGLYRQVAVVIDRQRRILAFLAQPYLEHDEQALKAHVQRLLP
DYMHPAVYTLLPGMPFASNGKVDRKALLEIPLSFTGQHTRRLPETEQQQALLGLWSELLELPPDDISTDDSFFNLGGHSI
LLSRLLLGVRERFGRSIPINRFIEAPTVLTLASLIDSDGTSAGVLSAQALRDANPDFQLATLPVSRLGDVHKVIVTGANG
FLGVHIVEALLNRGATEIACLVREAAGQSAQQRFEDALRENRLDHLDLSRVQVYPADLTKPRLGLSEAVYERLDLEFGAL
VHNAANVNHVQDYESLVKDNVAPVFECLKLCEGRSKKIFNFVSTLSACSAIDAAGNVLEQPAATTPPIYIKNGYNLSKWV
AERILQCARDQGVWVNIYRPGNIAFNSVTGVCQPQKNRLMLMLKGSLQLGQVPAFAINFDLMPVDFLARFIGFHASRYQP
EHAVFNLHNPEPLSWGDYVHAFREAGRQFELVSVEQWQMQLRRVDSQNALFGVLGFYLDGFEEDIGDISMIEHRNTLNGI
RRMGEQYPQKTPALLRRGCEYLKEIDFI

Sequences:

>Translated_1148_residues
MKRLEIVLIGHSLTLSELNSELLDHGHGVRHLSDQQALDALTVPDGGVLIEDGSLDLSEEQLNAFGHCTQLRLRVGFSKA
LDHGLPRLELLCWHGAAEARRLIVHKWLAVEESGNGRVLRDAAVAAMVDLATLQISRLSRDEDCLNGMTSVTPARSDRQH
GLQAVDQLLFEHRFNQTDQPHLLKLSETPITERLEQALLTFAERPALSVRNRTLSYRQLHAHSLAIQSLLQPLLAHAKAG
TPAVIGICLHKSAELYAGILAVLGCGAVYLPLDPGQPVQRQQYILENSGAMLLLHDGSHPLAAAEFPALDIATVPVGDGA
PTHVRVATDQDAPCMALYTSGTTGQPKGVLLSQRNLSHFTAWYAEHVSLSEHSRVLQFSTLSFDSSIIDIFPTWLSGAEL
VVPDEDQRRDPLQLVSALQQGITHAFLPPALLSILPLDQPLGLEHVMTGGDVCEPHVIAQLTRQCHFHNLYGPTEATVLV
TACEFGPSSSNRHLGRPIANSQAWILDEQLQPVAEQTQGELYIIGPGVCLGYVNNPALTAERYVWLTKPDGQLMRAYRTG
DIAKWTADGIVLSGRRDNQVKIRGFRVEPEEIEHCLRDSGLYRQVAVVIDRQRRILAFLAQPYLEHDEQALKAHVQRLLP
DYMHPAVYTLLPGMPFASNGKVDRKALLEIPLSFTGQHTRRLPETEQQQALLGLWSELLELPPDDISTDDSFFNLGGHSI
LLSRLLLGVRERFGRSIPINRFIEAPTVLTLASLIDSDGTSAGVLSAQALRDANPDFQLATLPVSRLGDVHKVIVTGANG
FLGVHIVEALLNRGATEIACLVREAAGQSAQQRFEDALRENRLDHLDLSRVQVYPADLTKPRLGLSEAVYERLDLEFGAL
VHNAANVNHVQDYESLVKDNVAPVFECLKLCEGRSKKIFNFVSTLSACSAIDAAGNVLEQPAATTPPIYIKNGYNLSKWV
AERILQCARDQGVWVNIYRPGNIAFNSVTGVCQPQKNRLMLMLKGSLQLGQVPAFAINFDLMPVDFLARFIGFHASRYQP
EHAVFNLHNPEPLSWGDYVHAFREAGRQFELVSVEQWQMQLRRVDSQNALFGVLGFYLDGFEEDIGDISMIEHRNTLNGI
RRMGEQYPQKTPALLRRGCEYLKEIDFI
>Mature_1148_residues
MKRLEIVLIGHSLTLSELNSELLDHGHGVRHLSDQQALDALTVPDGGVLIEDGSLDLSEEQLNAFGHCTQLRLRVGFSKA
LDHGLPRLELLCWHGAAEARRLIVHKWLAVEESGNGRVLRDAAVAAMVDLATLQISRLSRDEDCLNGMTSVTPARSDRQH
GLQAVDQLLFEHRFNQTDQPHLLKLSETPITERLEQALLTFAERPALSVRNRTLSYRQLHAHSLAIQSLLQPLLAHAKAG
TPAVIGICLHKSAELYAGILAVLGCGAVYLPLDPGQPVQRQQYILENSGAMLLLHDGSHPLAAAEFPALDIATVPVGDGA
PTHVRVATDQDAPCMALYTSGTTGQPKGVLLSQRNLSHFTAWYAEHVSLSEHSRVLQFSTLSFDSSIIDIFPTWLSGAEL
VVPDEDQRRDPLQLVSALQQGITHAFLPPALLSILPLDQPLGLEHVMTGGDVCEPHVIAQLTRQCHFHNLYGPTEATVLV
TACEFGPSSSNRHLGRPIANSQAWILDEQLQPVAEQTQGELYIIGPGVCLGYVNNPALTAERYVWLTKPDGQLMRAYRTG
DIAKWTADGIVLSGRRDNQVKIRGFRVEPEEIEHCLRDSGLYRQVAVVIDRQRRILAFLAQPYLEHDEQALKAHVQRLLP
DYMHPAVYTLLPGMPFASNGKVDRKALLEIPLSFTGQHTRRLPETEQQQALLGLWSELLELPPDDISTDDSFFNLGGHSI
LLSRLLLGVRERFGRSIPINRFIEAPTVLTLASLIDSDGTSAGVLSAQALRDANPDFQLATLPVSRLGDVHKVIVTGANG
FLGVHIVEALLNRGATEIACLVREAAGQSAQQRFEDALRENRLDHLDLSRVQVYPADLTKPRLGLSEAVYERLDLEFGAL
VHNAANVNHVQDYESLVKDNVAPVFECLKLCEGRSKKIFNFVSTLSACSAIDAAGNVLEQPAATTPPIYIKNGYNLSKWV
AERILQCARDQGVWVNIYRPGNIAFNSVTGVCQPQKNRLMLMLKGSLQLGQVPAFAINFDLMPVDFLARFIGFHASRYQP
EHAVFNLHNPEPLSWGDYVHAFREAGRQFELVSVEQWQMQLRRVDSQNALFGVLGFYLDGFEEDIGDISMIEHRNTLNGI
RRMGEQYPQKTPALLRRGCEYLKEIDFI

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=438, Percent_Identity=26.4840182648402, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI38505220, Length=370, Percent_Identity=26.2162162162162, Blast_Score=79, Evalue=3e-14,
Organism=Homo sapiens, GI122937307, Length=373, Percent_Identity=26.2734584450402, Blast_Score=77, Evalue=1e-13,
Organism=Homo sapiens, GI115511026, Length=384, Percent_Identity=25, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786801, Length=634, Percent_Identity=30.1261829652997, Blast_Score=212, Evalue=1e-55,
Organism=Escherichia coli, GI1788107, Length=356, Percent_Identity=26.9662921348315, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17556356, Length=537, Percent_Identity=25.3258845437616, Blast_Score=140, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550940, Length=539, Percent_Identity=24.6753246753247, Blast_Score=120, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32564422, Length=410, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32564420, Length=410, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319591, Length=1076, Percent_Identity=24.3494423791822, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI24648676, Length=743, Percent_Identity=25.9757738896366, Blast_Score=151, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 127127; Mature: 127127

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50075 ACP_DOMAIN ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLEIVLIGHSLTLSELNSELLDHGHGVRHLSDQQALDALTVPDGGVLIEDGSLDLSEE
CCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCEEECCCCCEEEECCCCCCCHH
QLNAFGHCTQLRLRVGFSKALDHGLPRLELLCWHGAAEARRLIVHKWLAVEESGNGRVLR
HHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHEEEECCCCCEEH
DAAVAAMVDLATLQISRLSRDEDCLNGMTSVTPARSDRQHGLQAVDQLLFEHRFNQTDQP
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
HLLKLSETPITERLEQALLTFAERPALSVRNRTLSYRQLHAHSLAIQSLLQPLLAHAKAG
CEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPAVIGICLHKSAELYAGILAVLGCGAVYLPLDPGQPVQRQQYILENSGAMLLLHDGSHP
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCC
LAAAEFPALDIATVPVGDGAPTHVRVATDQDAPCMALYTSGTTGQPKGVLLSQRNLSHFT
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCHHHH
AWYAEHVSLSEHSRVLQFSTLSFDSSIIDIFPTWLSGAELVVPDEDQRRDPLQLVSALQQ
HHHHHHCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
GITHAFLPPALLSILPLDQPLGLEHVMTGGDVCEPHVIAQLTRQCHFHNLYGPTEATVLV
CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
TACEFGPSSSNRHLGRPIANSQAWILDEQLQPVAEQTQGELYIIGPGVCLGYVNNPALTA
EEECCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEE
ERYVWLTKPDGQLMRAYRTGDIAKWTADGIVLSGRRDNQVKIRGFRVEPEEIEHCLRDSG
EEEEEEECCCHHHHHHHHCCCCEEEECCCEEEECCCCCEEEEEEEECCHHHHHHHHHCCC
LYRQVAVVIDRQRRILAFLAQPYLEHDEQALKAHVQRLLPDYMHPAVYTLLPGMPFASNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC
KVDRKALLEIPLSFTGQHTRRLPETEQQQALLGLWSELLELPPDDISTDDSFFNLGGHSI
CCCHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHH
LLSRLLLGVRERFGRSIPINRFIEAPTVLTLASLIDSDGTSAGVLSAQALRDANPDFQLA
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
TLPVSRLGDVHKVIVTGANGFLGVHIVEALLNRGATEIACLVREAAGQSAQQRFEDALRE
ECCHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHH
NRLDHLDLSRVQVYPADLTKPRLGLSEAVYERLDLEFGALVHNAANVNHVQDYESLVKDN
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCC
VAPVFECLKLCEGRSKKIFNFVSTLSACSAIDAAGNVLEQPAATTPPIYIKNGYNLSKWV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHH
AERILQCARDQGVWVNIYRPGNIAFNSVTGVCQPQKNRLMLMLKGSLQLGQVPAFAINFD
HHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEC
LMPVDFLARFIGFHASRYQPEHAVFNLHNPEPLSWGDYVHAFREAGRQFELVSVEQWQMQ
CCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHH
LRRVDSQNALFGVLGFYLDGFEEDIGDISMIEHRNTLNGIRRMGEQYPQKTPALLRRGCE
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
YLKEIDFI
HHHHCCCC
>Mature Secondary Structure
MKRLEIVLIGHSLTLSELNSELLDHGHGVRHLSDQQALDALTVPDGGVLIEDGSLDLSEE
CCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCEEECCCCCEEEECCCCCCCHH
QLNAFGHCTQLRLRVGFSKALDHGLPRLELLCWHGAAEARRLIVHKWLAVEESGNGRVLR
HHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHEEEECCCCCEEH
DAAVAAMVDLATLQISRLSRDEDCLNGMTSVTPARSDRQHGLQAVDQLLFEHRFNQTDQP
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
HLLKLSETPITERLEQALLTFAERPALSVRNRTLSYRQLHAHSLAIQSLLQPLLAHAKAG
CEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPAVIGICLHKSAELYAGILAVLGCGAVYLPLDPGQPVQRQQYILENSGAMLLLHDGSHP
CCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCC
LAAAEFPALDIATVPVGDGAPTHVRVATDQDAPCMALYTSGTTGQPKGVLLSQRNLSHFT
CCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCHHHH
AWYAEHVSLSEHSRVLQFSTLSFDSSIIDIFPTWLSGAELVVPDEDQRRDPLQLVSALQQ
HHHHHHCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
GITHAFLPPALLSILPLDQPLGLEHVMTGGDVCEPHVIAQLTRQCHFHNLYGPTEATVLV
CCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE
TACEFGPSSSNRHLGRPIANSQAWILDEQLQPVAEQTQGELYIIGPGVCLGYVNNPALTA
EEECCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHCCCCEEEEECCEEEEECCCCCEEE
ERYVWLTKPDGQLMRAYRTGDIAKWTADGIVLSGRRDNQVKIRGFRVEPEEIEHCLRDSG
EEEEEEECCCHHHHHHHHCCCCEEEECCCEEEECCCCCEEEEEEEECCHHHHHHHHHCCC
LYRQVAVVIDRQRRILAFLAQPYLEHDEQALKAHVQRLLPDYMHPAVYTLLPGMPFASNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC
KVDRKALLEIPLSFTGQHTRRLPETEQQQALLGLWSELLELPPDDISTDDSFFNLGGHSI
CCCHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHH
LLSRLLLGVRERFGRSIPINRFIEAPTVLTLASLIDSDGTSAGVLSAQALRDANPDFQLA
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
TLPVSRLGDVHKVIVTGANGFLGVHIVEALLNRGATEIACLVREAAGQSAQQRFEDALRE
ECCHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHH
NRLDHLDLSRVQVYPADLTKPRLGLSEAVYERLDLEFGALVHNAANVNHVQDYESLVKDN
CCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCC
VAPVFECLKLCEGRSKKIFNFVSTLSACSAIDAAGNVLEQPAATTPPIYIKNGYNLSKWV
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHH
AERILQCARDQGVWVNIYRPGNIAFNSVTGVCQPQKNRLMLMLKGSLQLGQVPAFAINFD
HHHHHHHHCCCCEEEEEEECCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEC
LMPVDFLARFIGFHASRYQPEHAVFNLHNPEPLSWGDYVHAFREAGRQFELVSVEQWQMQ
CCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHHH
LRRVDSQNALFGVLGFYLDGFEEDIGDISMIEHRNTLNGIRRMGEQYPQKTPALLRRGCE
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
YLKEIDFI
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA