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The map label for this gene is serA [H]

Identifier: 66048076

GI number: 66048076

Start: 5759127

End: 5760356

Strand: Direct

Name: serA [H]

Synonym: Psyr_4852

Alternate gene names: 66048076

Gene position: 5759127-5760356 (Clockwise)

Preceding gene: 66048071

Following gene: 66048079

Centisome position: 94.51

GC content: 59.67

Gene sequence:

>1230_bases
ATGAGCAAGACTTCCCTCGACAAGAGCAAGATCAAGTTCCTTCTTCTCGAAGGCGTCCACCAATCCGCTGTCGACGTCCT
CAAGGCAGCCGGTTACACCAGCATCGAGTACCACACCAAGTCTCTGCCGGAAGCCGAACTGAAAGAAAAGATCGCCGACG
CCCATTTCATCGGTATCCGCTCTCGTACTCAGTTGACCGAAGAGCTGTTCGATTGCGCCAAGAAACTGGTTGCGGTCGGC
TGCTTCTGCATCGGCACCAACCAGGTTGACCTCAACGCGGCGCGCGAGCGCGGTATCGCAGTGTTCAATGCGCCCTACTC
CAATACCCGTTCGGTCGCCGAACTGGTATTGGCCGAAGCCATCCTGCTGCTGCGCGGTATCCCCGAGAAGAACGCTTCCT
GCCACCGTGGCGGCTGGATCAAGAGTGCGGCCAACTCCTTCGAGATCCGTGGCAAGAAGCTGGGCATCATCGGTTATGGT
TCGATCGGTACGCAGCTGTCGGTGCTGGCCGAAGGTCTGGGCATGCAGGTGTACTTCTACGACACGCTGACCAAACTGCC
GCTGGGCAACGCCACTCAGGTGTCGAGCCTGAACGAGCTGCTGGGCATGTCCGATATCGTCACTCTGCACGTTCCGGAAA
CCTCGGAAACCCAGTGGATGATCGGCGAGAAAGAAATCCGCGCGATGAGGAAGGGCAGCATCCTGATCAACGCCGCGCGT
GGCACGGTGGTCGAACTGGACGCACTGGCTGACGCCATCAAGGACAAGCACCTGATCGGCGCCGCCATCGACGTGTTCCC
GGTCGAGCCGCGCTCGAACGACGACATCTTCGAAAGCCCGCTGCGCGGTCTGGACAACGTGATCCTGACGCCGCACATCG
GTGGCTCCACAGCCGAAGCGCAGGCCAACATCGGTCTGGAAGTGGCGGAAAAACTGGTCAAGTACAGCGACAACGGTACG
TCGGTGTCCTCGGTCAACTTCCCGGAAGTGGCGCTGCCTGCGCACCCTGGCAAGCACCGCCTGCTGCACATCCACGAAAA
CATCCCGGGCGTGCTCAGCGAGATCAACAAGGTCTTCGCCGAAAACGGTATCAACATCTCCGGTCAGTTCCTGCAGACCA
ACGAGAAAGTCGGCTACGTGGTCATCGACGTCGACGCCGAATACTCCGACCTCGCCCAGGCCAAGCTGCAACAGATCAAA
GGCACCATCCGCAGCCGCGTGCTGTTCTGA

Upstream 100 bases:

>100_bases
TTCGCGGGGCTCATATGCTAGCATACGCCCCCCGCGAGTCGTGCCCAGAGCCGATCCGGCCACCCCCTGCCAATTTTCTT
CGGGACACAGGTTTACGCAG

Downstream 100 bases:

>100_bases
TCTGATCGCCGTGCCCACCCCGTGTGGGCACGAGCGATGTTCTTGCGGGCACCTATCGTTCCTCACGCTCCAGCATGGGA
GTGCAGTTCACGACGCTCCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYHTKSLPEAELKEKIADAHFIGIRSRTQLTEELFDCAKKLVAVG
CFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIIGYG
SIGTQLSVLAEGLGMQVYFYDTLTKLPLGNATQVSSLNELLGMSDIVTLHVPETSETQWMIGEKEIRAMRKGSILINAAR
GTVVELDALADAIKDKHLIGAAIDVFPVEPRSNDDIFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGT
SVSSVNFPEVALPAHPGKHRLLHIHENIPGVLSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSDLAQAKLQQIK
GTIRSRVLF

Sequences:

>Translated_409_residues
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYHTKSLPEAELKEKIADAHFIGIRSRTQLTEELFDCAKKLVAVG
CFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIIGYG
SIGTQLSVLAEGLGMQVYFYDTLTKLPLGNATQVSSLNELLGMSDIVTLHVPETSETQWMIGEKEIRAMRKGSILINAAR
GTVVELDALADAIKDKHLIGAAIDVFPVEPRSNDDIFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGT
SVSSVNFPEVALPAHPGKHRLLHIHENIPGVLSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSDLAQAKLQQIK
GTIRSRVLF
>Mature_408_residues
SKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYHTKSLPEAELKEKIADAHFIGIRSRTQLTEELFDCAKKLVAVGC
FCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIIGYGS
IGTQLSVLAEGLGMQVYFYDTLTKLPLGNATQVSSLNELLGMSDIVTLHVPETSETQWMIGEKEIRAMRKGSILINAARG
TVVELDALADAIKDKHLIGAAIDVFPVEPRSNDDIFESPLRGLDNVILTPHIGGSTAEAQANIGLEVAEKLVKYSDNGTS
VSSVNFPEVALPAHPGKHRLLHIHENIPGVLSEINKVFAENGINISGQFLQTNEKVGYVVIDVDAEYSDLAQAKLQQIKG
TIRSRVLF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=31.2302839116719, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI61743967, Length=257, Percent_Identity=31.5175097276265, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557497, Length=257, Percent_Identity=31.5175097276265, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=32.9218106995885, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=32.9218106995885, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI145580575, Length=244, Percent_Identity=33.6065573770492, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI6912396, Length=281, Percent_Identity=25.6227758007117, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1789279, Length=412, Percent_Identity=66.2621359223301, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=29.4964028776978, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1787645, Length=234, Percent_Identity=29.9145299145299, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788660, Length=280, Percent_Identity=29.6428571428571, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=32.6086956521739, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=286, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=50, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322116, Length=415, Percent_Identity=48.9156626506024, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324964, Length=257, Percent_Identity=29.1828793774319, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=254, Percent_Identity=25.1968503937008, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=32.0987654320988, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=27, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=29.153605015674, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28571528, Length=297, Percent_Identity=30.6397306397306, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI62472511, Length=247, Percent_Identity=32.3886639676113, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=32.3886639676113, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=32.3886639676113, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=32.3886639676113, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=32.3886639676113, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=29.5880149812734, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24585514, Length=305, Percent_Identity=26.8852459016393, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574282, Length=305, Percent_Identity=26.8852459016393, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI28574284, Length=305, Percent_Identity=26.8852459016393, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45552429, Length=305, Percent_Identity=26.8852459016393, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI45551003, Length=305, Percent_Identity=26.8852459016393, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=24.5847176079734, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44340; Mature: 44209

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYHTKSLPEAELKEKIADAHFIGIR
CCCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCHHEEECC
SRTQLTEELFDCAKKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA
HHHHHHHHHHHHHHHHHHHHEEEEECCEEECHHHHHCCEEEEECCCCCHHHHHHHHHHHH
ILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIIGYGSIGTQLSVLAEGLGMQVYFY
HHHHHCCCCCCCCCCCCCCHHHCCCCEEECCEEEEEEEECCCHHHHHHHHHCCCCEEEEE
DTLTKLPLGNATQVSSLNELLGMSDIVTLHVPETSETQWMIGEKEIRAMRKGSILINAAR
EHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHHCCCEEEEECC
GTVVELDALADAIKDKHLIGAAIDVFPVEPRSNDDIFESPLRGLDNVILTPHIGGSTAEA
CCEEEHHHHHHHHHCCHHEEEEEEEEECCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCH
QANIGLEVAEKLVKYSDNGTSVSSVNFPEVALPAHPGKHRLLHIHENIPGVLSEINKVFA
HHCCCHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
ENGINISGQFLQTNEKVGYVVIDVDAEYSDLAQAKLQQIKGTIRSRVLF
HCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKTSLDKSKIKFLLLEGVHQSAVDVLKAAGYTSIEYHTKSLPEAELKEKIADAHFIGIR
CCCCCCHHHHHHHEECCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCHHEEECC
SRTQLTEELFDCAKKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA
HHHHHHHHHHHHHHHHHHHHEEEEECCEEECHHHHHCCEEEEECCCCCHHHHHHHHHHHH
ILLLRGIPEKNASCHRGGWIKSAANSFEIRGKKLGIIGYGSIGTQLSVLAEGLGMQVYFY
HHHHHCCCCCCCCCCCCCCHHHCCCCEEECCEEEEEEEECCCHHHHHHHHHCCCCEEEEE
DTLTKLPLGNATQVSSLNELLGMSDIVTLHVPETSETQWMIGEKEIRAMRKGSILINAAR
EHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECHHHHHHHHCCCEEEEECC
GTVVELDALADAIKDKHLIGAAIDVFPVEPRSNDDIFESPLRGLDNVILTPHIGGSTAEA
CCEEEHHHHHHHHHCCHHEEEEEEEEECCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCH
QANIGLEVAEKLVKYSDNGTSVSSVNFPEVALPAHPGKHRLLHIHENIPGVLSEINKVFA
HHCCCHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
ENGINISGQFLQTNEKVGYVVIDVDAEYSDLAQAKLQQIKGTIRSRVLF
HCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]