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The map label for this gene is hutH [H]

Identifier: 66048056

GI number: 66048056

Start: 5734563

End: 5736104

Strand: Direct

Name: hutH [H]

Synonym: Psyr_4832

Alternate gene names: 66048056

Gene position: 5734563-5736104 (Clockwise)

Preceding gene: 66048055

Following gene: 66048057

Centisome position: 94.11

GC content: 64.53

Gene sequence:

>1542_bases
ATGTCGCGAGCAGAACAGATCGTCATCGGTGAAGCACCTGCGGGCTGGCAGGACGTGGTCGCCGTGGCTCGACATGGCGC
AAGACTGGTCCTGTCGGACGCCGCCTGGGCACGGATCGACAACGCTCAGGCCATCGTGCAGCGCATCGTCGTCAGCGGCG
AGCGCGCCTATGGCGTGAACACCGGGCTCGGCGCGCTGTGCAATGTGTCACTGCAAGGCGAACAGCTCAGTCGCCTGTCG
CGCAATACCCTGCTCAGCCATGCCTGCGGCGTCGGTACGCCACTGGCCGACGAGCAGACCCGCGCAATCATCTGCGCCGC
GATTCTCAACTACAGCCAGGGCAAGTCCGGCATTCACCGGCAAGTGGTCGAAGCGCTGCTGGCCTTGCTCAACCGCGGCA
TCACGCCGCAAGTACCGGCGCAGGGCTCGGTGGGTTATCTGACGCACATGGCGCACGTCGGTGTTGCGTTGCTGGGCATC
GGTCAGGTCAGCTATCGCGGGCAGATCGTCCCGGCTGAGCAGGCCTTGAACGAAGAGGGTCTGGTTCCGGTCATCCTCGG
AGCCAAGGACGGTTTGTGTCTGGTCAACGGCACACCGTGCATGACCGGCCTGAGCTGTCTGGCCATCGCTGATGCCGAGC
GCCTGAGCCAATGGGCCGACGTGATCGGCGCGATGAGCTTCGAAGCCCTGCGCGGCCAGCTGGACGCATTCGATGCAAGC
ATTCTCGCCCTCAAGCCGCATCCGGGCATGCAGCAGGTGGGCAAGAACCTGCGCATGTTGTTGGCAGGCAGCGACGTGCT
CGCCAGCAGTGAAGGCATTCGCACTCAAGATGCGCTGAGTATCCGTTCGATTCCCCAGGTGCATGGTGCCACCCGCGACC
AGTTGGCTCACGCCACTCGGCAGGTCGAGATCGAGCTCAATTCAGTCACCGATAACCCGCTGCTGCTCGGCACGCCCGAG
GCTTTCCGCGTGGTGTCCCAGGCCAATCCACACGGCCAGTCGGTGGCCATGGCGGCAGACCTGCTGTGCATGGCGATGGC
CGAGCTGGGCTCGATCGCCGAACGACGCCTCGACCGCCTGATCAACCCGATGGTCAGCGGCCTGCCGGCGTTTCTGGTCA
CCCAGCCGGGCGTCAACTCGGGAATGATGATCGTCCAGTACGTCGCCGCTTCGCTGTGCGCGGAAAACCGCCAGATGGCG
CAACCGGCCGTGGTCGACAACTACGTGACCTCCGGTCTGCAGGAGGATCACCTGAGCCTGGGCACCAGCGCCGCGCTCAA
GCTGCACAAGGTGCTGGGCAATACCACGCAGATTCTGGCCATCGAGTATCTGCTCGCGGCCCAGGCGTTCGAATTTCTCA
AGACACAGGGTTTTGGCGTGGGCACCGGTGCCGCGTGGCGACTGCTGCGCGAGCGCATTCCGGCCTACGACGAAGACCGC
TGGCTGGCCCCGGACATCGCCAGCAGCGCGGCCCTGCTCAAAGACGAAACGTCGCTGGAAAGGGTTTTCCAGCACTGCCG
TGACAACGCGGCAGGCCTATAA

Upstream 100 bases:

>100_bases
TCAGGTCGGTACGCCGAAAGAAATCCTTCATTCGCCCGCCGACGATTACGTGGATCGTTTCGTTCAGCGCCGCGTAGCCA
CCCTTTAAGGACCGTTGCAG

Downstream 100 bases:

>100_bases
AAGCAGCGTACGGCCACACGCCGTCGCTGACACTTATCAAGGAGTAGCAGCATCGTGACCACCTTATCTGCCAAGACGCT
GAACCTGATCCCCAGCCAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSRAEQIVIGEAPAGWQDVVAVARHGARLVLSDAAWARIDNAQAIVQRIVVSGERAYGVNTGLGALCNVSLQGEQLSRLS
RNTLLSHACGVGTPLADEQTRAIICAAILNYSQGKSGIHRQVVEALLALLNRGITPQVPAQGSVGYLTHMAHVGVALLGI
GQVSYRGQIVPAEQALNEEGLVPVILGAKDGLCLVNGTPCMTGLSCLAIADAERLSQWADVIGAMSFEALRGQLDAFDAS
ILALKPHPGMQQVGKNLRMLLAGSDVLASSEGIRTQDALSIRSIPQVHGATRDQLAHATRQVEIELNSVTDNPLLLGTPE
AFRVVSQANPHGQSVAMAADLLCMAMAELGSIAERRLDRLINPMVSGLPAFLVTQPGVNSGMMIVQYVAASLCAENRQMA
QPAVVDNYVTSGLQEDHLSLGTSAALKLHKVLGNTTQILAIEYLLAAQAFEFLKTQGFGVGTGAAWRLLRERIPAYDEDR
WLAPDIASSAALLKDETSLERVFQHCRDNAAGL

Sequences:

>Translated_513_residues
MSRAEQIVIGEAPAGWQDVVAVARHGARLVLSDAAWARIDNAQAIVQRIVVSGERAYGVNTGLGALCNVSLQGEQLSRLS
RNTLLSHACGVGTPLADEQTRAIICAAILNYSQGKSGIHRQVVEALLALLNRGITPQVPAQGSVGYLTHMAHVGVALLGI
GQVSYRGQIVPAEQALNEEGLVPVILGAKDGLCLVNGTPCMTGLSCLAIADAERLSQWADVIGAMSFEALRGQLDAFDAS
ILALKPHPGMQQVGKNLRMLLAGSDVLASSEGIRTQDALSIRSIPQVHGATRDQLAHATRQVEIELNSVTDNPLLLGTPE
AFRVVSQANPHGQSVAMAADLLCMAMAELGSIAERRLDRLINPMVSGLPAFLVTQPGVNSGMMIVQYVAASLCAENRQMA
QPAVVDNYVTSGLQEDHLSLGTSAALKLHKVLGNTTQILAIEYLLAAQAFEFLKTQGFGVGTGAAWRLLRERIPAYDEDR
WLAPDIASSAALLKDETSLERVFQHCRDNAAGL
>Mature_512_residues
SRAEQIVIGEAPAGWQDVVAVARHGARLVLSDAAWARIDNAQAIVQRIVVSGERAYGVNTGLGALCNVSLQGEQLSRLSR
NTLLSHACGVGTPLADEQTRAIICAAILNYSQGKSGIHRQVVEALLALLNRGITPQVPAQGSVGYLTHMAHVGVALLGIG
QVSYRGQIVPAEQALNEEGLVPVILGAKDGLCLVNGTPCMTGLSCLAIADAERLSQWADVIGAMSFEALRGQLDAFDASI
LALKPHPGMQQVGKNLRMLLAGSDVLASSEGIRTQDALSIRSIPQVHGATRDQLAHATRQVEIELNSVTDNPLLLGTPEA
FRVVSQANPHGQSVAMAADLLCMAMAELGSIAERRLDRLINPMVSGLPAFLVTQPGVNSGMMIVQYVAASLCAENRQMAQ
PAVVDNYVTSGLQEDHLSLGTSAALKLHKVLGNTTQILAIEYLLAAQAFEFLKTQGFGVGTGAAWRLLRERIPAYDEDRW
LAPDIASSAALLKDETSLERVFQHCRDNAAGL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=493, Percent_Identity=35.4969574036511, Blast_Score=302, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17567831, Length=498, Percent_Identity=36.3453815261044, Blast_Score=278, Evalue=7e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54424; Mature: 54293

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAEQIVIGEAPAGWQDVVAVARHGARLVLSDAAWARIDNAQAIVQRIVVSGERAYGVN
CCCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCC
TGLGALCNVSLQGEQLSRLSRNTLLSHACGVGTPLADEQTRAIICAAILNYSQGKSGIHR
CCCHHHEECEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
QVVEALLALLNRGITPQVPAQGSVGYLTHMAHVGVALLGIGQVSYRGQIVPAEQALNEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHCCCCC
LVPVILGAKDGLCLVNGTPCMTGLSCLAIADAERLSQWADVIGAMSFEALRGQLDAFDAS
CEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ILALKPHPGMQQVGKNLRMLLAGSDVLASSEGIRTQDALSIRSIPQVHGATRDQLAHATR
EEEECCCCCHHHHCCHHEEEEECCHHHCCCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHE
QVEIELNSVTDNPLLLGTPEAFRVVSQANPHGQSVAMAADLLCMAMAELGSIAERRLDRL
EEEEEEECCCCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INPMVSGLPAFLVTQPGVNSGMMIVQYVAASLCAENRQMAQPAVVDNYVTSGLQEDHLSL
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHC
GTSAALKLHKVLGNTTQILAIEYLLAAQAFEFLKTQGFGVGTGAAWRLLRERIPAYDEDR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
WLAPDIASSAALLKDETSLERVFQHCRDNAAGL
CCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRAEQIVIGEAPAGWQDVVAVARHGARLVLSDAAWARIDNAQAIVQRIVVSGERAYGVN
CCCCEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCC
TGLGALCNVSLQGEQLSRLSRNTLLSHACGVGTPLADEQTRAIICAAILNYSQGKSGIHR
CCCHHHEECEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
QVVEALLALLNRGITPQVPAQGSVGYLTHMAHVGVALLGIGQVSYRGQIVPAEQALNEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECHHHHCCCCC
LVPVILGAKDGLCLVNGTPCMTGLSCLAIADAERLSQWADVIGAMSFEALRGQLDAFDAS
CEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ILALKPHPGMQQVGKNLRMLLAGSDVLASSEGIRTQDALSIRSIPQVHGATRDQLAHATR
EEEECCCCCHHHHCCHHEEEEECCHHHCCCCCCCCHHHHHHHCCHHHCCCCHHHHHHHHE
QVEIELNSVTDNPLLLGTPEAFRVVSQANPHGQSVAMAADLLCMAMAELGSIAERRLDRL
EEEEEEECCCCCCEEEECHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INPMVSGLPAFLVTQPGVNSGMMIVQYVAASLCAENRQMAQPAVVDNYVTSGLQEDHLSL
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHC
GTSAALKLHKVLGNTTQILAIEYLLAAQAFEFLKTQGFGVGTGAAWRLLRERIPAYDEDR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCC
WLAPDIASSAALLKDETSLERVFQHCRDNAAGL
CCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA