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The map label for this gene is polC [H]

Identifier: 66047927

GI number: 66047927

Start: 5573947

End: 5574660

Strand: Direct

Name: polC [H]

Synonym: Psyr_4703

Alternate gene names: 66047927

Gene position: 5573947-5574660 (Clockwise)

Preceding gene: 66047926

Following gene: 66047930

Centisome position: 91.47

GC content: 61.2

Gene sequence:

>714_bases
ATGAACCTGTTCGAATGGCTCAAACCACGGCCGAAAAAGACACCCTTGCACGCGCACCAACTGGAGCGCCTTAAACGACT
GCCGGTGTGCGCGAACCTCAGTGACACGTCACTGCGTGAACAGCGCTGGGTCGTGCTGGACCTGGAAACCAGTGGCCTGA
ACATGAACCGCGATCAGGTGCTGTCCATTGGTGCTGTGGTGATTGAAGACGGCGCCATCGATCTGGGCCAGCAGTTCGAG
CGCACGCTGTTGCGCGTCGACCACAAGATCAGTCCGGCCGTTCTGATTCATGGGCTGGCGCCCAGTGCGATTGCCGCTGG
CAGTGAGCCGGTCGAGGCCTTGCTGGACTTCATGGAGTTCGTCGGAGACAGCCCGATTCTCGGCTTTCATGCGCCATTCG
ATCAGCACATGCTGTCGCGCGCCTTGAAGGAAAGCCTGGGCTATCGCTTGCAGCACGCGTTTTTCGACGCCGCCGAAATC
GCCCCGATGCTCTGCGAGCACGCCAACCTGCGTCATGCCGGGCTGGATGACTGGACCCGTTTCTTTGGTCTGCATGCCGA
ACAGCGTCACCATGCCAGCGCCGATGCGCTGGTTACCGCAGAACTGGCGCTGATCCTGTTCAGCCACGCCCGTCGTCAGC
AGATCGACAGCCCCTTGCGGCTGGAGGAAGCACTCGGGCAGTGGCGCAGGCGCAGACAGTCGCATTCGTTCTGA

Upstream 100 bases:

>100_bases
TCGACCCCGACACACTCAACCATCTGGACCGGCGCATTCTGCGCGAATCGTTTCGCCAGGCGCAGCGATTGCAAACCAGC
CTGACCCTGCGTTATCAGCT

Downstream 100 bases:

>100_bases
CTGCGACTTCGTCAGCGCCTCCCGTTCAGTTCGGGGCGATGGTCTTGGCGATCACATCCACCGTCGCTTCAACCTGCTCC
CGGTAGCGCTTGAGCTCGAC

Product: exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNLFEWLKPRPKKTPLHAHQLERLKRLPVCANLSDTSLREQRWVVLDLETSGLNMNRDQVLSIGAVVIEDGAIDLGQQFE
RTLLRVDHKISPAVLIHGLAPSAIAAGSEPVEALLDFMEFVGDSPILGFHAPFDQHMLSRALKESLGYRLQHAFFDAAEI
APMLCEHANLRHAGLDDWTRFFGLHAEQRHHASADALVTAELALILFSHARRQQIDSPLRLEEALGQWRRRRQSHSF

Sequences:

>Translated_237_residues
MNLFEWLKPRPKKTPLHAHQLERLKRLPVCANLSDTSLREQRWVVLDLETSGLNMNRDQVLSIGAVVIEDGAIDLGQQFE
RTLLRVDHKISPAVLIHGLAPSAIAAGSEPVEALLDFMEFVGDSPILGFHAPFDQHMLSRALKESLGYRLQHAFFDAAEI
APMLCEHANLRHAGLDDWTRFFGLHAEQRHHASADALVTAELALILFSHARRQQIDSPLRLEEALGQWRRRRQSHSF
>Mature_237_residues
MNLFEWLKPRPKKTPLHAHQLERLKRLPVCANLSDTSLREQRWVVLDLETSGLNMNRDQVLSIGAVVIEDGAIDLGQQFE
RTLLRVDHKISPAVLIHGLAPSAIAAGSEPVEALLDFMEFVGDSPILGFHAPFDQHMLSRALKESLGYRLQHAFFDAAEI
APMLCEHANLRHAGLDDWTRFFGLHAEQRHHASADALVTAELALILFSHARRQQIDSPLRLEEALGQWRRRRQSHSF

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 26849; Mature: 26849

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFEWLKPRPKKTPLHAHQLERLKRLPVCANLSDTSLREQRWVVLDLETSGLNMNRDQV
CCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHH
LSIGAVVIEDGAIDLGQQFERTLLRVDHKISPAVLIHGLAPSAIAAGSEPVEALLDFMEF
HHHHHHEEECCCCHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHCCCHHHHHHHHHHHH
VGDSPILGFHAPFDQHMLSRALKESLGYRLQHAFFDAAEIAPMLCEHANLRHAGLDDWTR
HCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FFGLHAEQRHHASADALVTAELALILFSHARRQQIDSPLRLEEALGQWRRRRQSHSF
HHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLFEWLKPRPKKTPLHAHQLERLKRLPVCANLSDTSLREQRWVVLDLETSGLNMNRDQV
CCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHCCEEEEEEECCCCCCCHHHH
LSIGAVVIEDGAIDLGQQFERTLLRVDHKISPAVLIHGLAPSAIAAGSEPVEALLDFMEF
HHHHHHEEECCCCHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHCCCHHHHHHHHHHHH
VGDSPILGFHAPFDQHMLSRALKESLGYRLQHAFFDAAEIAPMLCEHANLRHAGLDDWTR
HCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FFGLHAEQRHHASADALVTAELALILFSHARRQQIDSPLRLEEALGQWRRRRQSHSF
HHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]