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The map label for this gene is holA [H]

Identifier: 66047581

GI number: 66047581

Start: 5208672

End: 5209709

Strand: Direct

Name: holA [H]

Synonym: Psyr_4354

Alternate gene names: 66047581

Gene position: 5208672-5209709 (Clockwise)

Preceding gene: 66047580

Following gene: 66047582

Centisome position: 85.48

GC content: 63.68

Gene sequence:

>1038_bases
ATGAAACTCGCCCCCGCCCAACTCGGCAAGCACTTGCAAGGCACACTGGCGCCCGTCTATGTGATCAGCGGTGACGATCC
GCTGCTCTGCCAGGAAGCAGCTGACGCCATTCGCGCAGCCGCACGCCAGCAAGGCTTCGATGAGCGGCAGGTATTCAGCG
CCGACGCCAGCTTCGACTGGGGCACATTGCTCCAGGCGGGTGCCAGCATGTCGCTGTTTGCCGAACGCCGTCTCCTGGAG
TTACGTCTGCCCTCCGGCAAGCCCGGCGACAAGGGTGCTGCGGCACTCATGGAATACTGCGCCAGACCTGCCGAAGACAC
CCTGCTGCTGATCAGCCTGCCCAAGCTCGATGGCAGTGCGCAGAAAACCAAATGGGGCAAGGCCCTGGTCGAGGGCGCGC
AAACCCAGTTCGTGCAAATCTGGCCGGTGGACATCGGCCAGCTGCCGCAATGGATTCGCCAGCGCCTGTCGCAGGCAGGT
CTGGCAGCCACTCAGGACGCTGTCGAACTGATCGCTGCCCGGGTCGAAGGCAACCTGTTGGCCGCCGCGCAGGAAATCGA
AAAGCTCAAATTGATGGCCGAAGAAGGCCAGATCACCGTCGAGACCGTGCAGGCGGCCGTAGCCGACAGTGCGCGCTTCG
ACGTATTTGGCCTGACCGATGCAGTGCTCAATGGCGAAGCTGCCCACGCGCTGCGCATGCTCGAAGGACTGCGTGGCGAA
GGGGTCGAAACGCCGGTGATTCTCTGGGCATTGACCCGCGAACTGCGCGCCCTGGCCAACATGTCGCAACAGTTCAGCCA
GGGCGTACCGCTGGACAAGGTGTTCAGCTCGGCACGCCCGCCGATCTGGGACAAGCGCAAGCCACTGATGAGCAAAGCCC
TGCAACGTCACTCGGCCAAACGCTGGAGCCAGCTGCTCATGGATGCGCAACGCGTCGATGCGCAGATCAAAGGCCAGGCA
GCAGGCTCGCCCTGGAGCAGCCTGAGCCGGCTGGCACTGCTGATGGCGGGGCAACGATTGGCATTGCCTGCGGAGTAG

Upstream 100 bases:

>100_bases
CCCAGCGAATCCGCGACGAGACGCCTCAGCAGTCGCCTGTCGAAGTTCCAGCCAGATAAGTGTCTGGGGCCGGTTCTCCG
GCCCCGACATGCTCTGACTC

Downstream 100 bases:

>100_bases
GCCTCATGTGCGACATACCTACTGGCCTGTTTGAGGTCGTTGCTCGTGCCATTTTCTATCCGGTCGGATGGCCTGTCGTA
AAACTCCTGACGCTTGGCAA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKLAPAQLGKHLQGTLAPVYVISGDDPLLCQEAADAIRAAARQQGFDERQVFSADASFDWGTLLQAGASMSLFAERRLLE
LRLPSGKPGDKGAAALMEYCARPAEDTLLLISLPKLDGSAQKTKWGKALVEGAQTQFVQIWPVDIGQLPQWIRQRLSQAG
LAATQDAVELIAARVEGNLLAAAQEIEKLKLMAEEGQITVETVQAAVADSARFDVFGLTDAVLNGEAAHALRMLEGLRGE
GVETPVILWALTRELRALANMSQQFSQGVPLDKVFSSARPPIWDKRKPLMSKALQRHSAKRWSQLLMDAQRVDAQIKGQA
AGSPWSSLSRLALLMAGQRLALPAE

Sequences:

>Translated_345_residues
MKLAPAQLGKHLQGTLAPVYVISGDDPLLCQEAADAIRAAARQQGFDERQVFSADASFDWGTLLQAGASMSLFAERRLLE
LRLPSGKPGDKGAAALMEYCARPAEDTLLLISLPKLDGSAQKTKWGKALVEGAQTQFVQIWPVDIGQLPQWIRQRLSQAG
LAATQDAVELIAARVEGNLLAAAQEIEKLKLMAEEGQITVETVQAAVADSARFDVFGLTDAVLNGEAAHALRMLEGLRGE
GVETPVILWALTRELRALANMSQQFSQGVPLDKVFSSARPPIWDKRKPLMSKALQRHSAKRWSQLLMDAQRVDAQIKGQA
AGSPWSSLSRLALLMAGQRLALPAE
>Mature_345_residues
MKLAPAQLGKHLQGTLAPVYVISGDDPLLCQEAADAIRAAARQQGFDERQVFSADASFDWGTLLQAGASMSLFAERRLLE
LRLPSGKPGDKGAAALMEYCARPAEDTLLLISLPKLDGSAQKTKWGKALVEGAQTQFVQIWPVDIGQLPQWIRQRLSQAG
LAATQDAVELIAARVEGNLLAAAQEIEKLKLMAEEGQITVETVQAAVADSARFDVFGLTDAVLNGEAAHALRMLEGLRGE
GVETPVILWALTRELRALANMSQQFSQGVPLDKVFSSARPPIWDKRKPLMSKALQRHSAKRWSQLLMDAQRVDAQIKGQA
AGSPWSSLSRLALLMAGQRLALPAE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=341, Percent_Identity=34.8973607038123, Blast_Score=166, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37361; Mature: 37361

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAPAQLGKHLQGTLAPVYVISGDDPLLCQEAADAIRAAARQQGFDERQVFSADASFDW
CCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCH
GTLLQAGASMSLFAERRLLELRLPSGKPGDKGAAALMEYCARPAEDTLLLISLPKLDGSA
HHHHHCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
QKTKWGKALVEGAQTQFVQIWPVDIGQLPQWIRQRLSQAGLAATQDAVELIAARVEGNLL
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHH
AAAQEIEKLKLMAEEGQITVETVQAAVADSARFDVFGLTDAVLNGEAAHALRMLEGLRGE
HHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHCCCCC
GVETPVILWALTRELRALANMSQQFSQGVPLDKVFSSARPPIWDKRKPLMSKALQRHSAK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RWSQLLMDAQRVDAQIKGQAAGSPWSSLSRLALLMAGQRLALPAE
HHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLAPAQLGKHLQGTLAPVYVISGDDPLLCQEAADAIRAAARQQGFDERQVFSADASFDW
CCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHEECCCCCCH
GTLLQAGASMSLFAERRLLELRLPSGKPGDKGAAALMEYCARPAEDTLLLISLPKLDGSA
HHHHHCCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
QKTKWGKALVEGAQTQFVQIWPVDIGQLPQWIRQRLSQAGLAATQDAVELIAARVEGNLL
HHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHH
AAAQEIEKLKLMAEEGQITVETVQAAVADSARFDVFGLTDAVLNGEAAHALRMLEGLRGE
HHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHCCCCC
GVETPVILWALTRELRALANMSQQFSQGVPLDKVFSSARPPIWDKRKPLMSKALQRHSAK
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RWSQLLMDAQRVDAQIKGQAAGSPWSSLSRLALLMAGQRLALPAE
HHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]