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The map label for this gene is thiD [H]

Identifier: 66047567

GI number: 66047567

Start: 5193951

End: 5194748

Strand: Direct

Name: thiD [H]

Synonym: Psyr_4340

Alternate gene names: 66047567

Gene position: 5193951-5194748 (Clockwise)

Preceding gene: 66047562

Following gene: 66047568

Centisome position: 85.23

GC content: 61.65

Gene sequence:

>798_bases
ATGAATATCTATAGCTCCCGCCCCGTAGTCCTTTGCCTGTCCGGCCACGACCCTAGTGGCGGTGCCGGTATGCAGGCCGA
TATAGAAGCCCTGCTCGCCCAAGGCTGCCATGCCGCTCCGGTCATTACCGCGCTTACGGTGCAAGACACCGTCAATGTCA
GTGATTTCCGCGTGCTGGATCGCGAATGGGTGATGGCGCAAGCCAATGCAGTCCTCAACGATTCGAGCGTAGCAGCTGTC
AAGCTGGGCATGCTCGGCTCACTGGAAATGGTCGATACGGTCGTCGATCTGCTTCTGGCTCACCCGCACTTGCCCATGGT
CTGTGATCCGGTGTTACGCGCTGGCGGCGGCGGCAGACTGGGCAAGGACGAGGTCGGCTACGCCATGCGCGAACGCCTGT
TGCCACTGTCGACCATCGCCACGCCGAACCTTCCGGAAGCCCGCATTCTTGCCGAGCTGCCCGAAGGTACTGCGGATGAG
TGCGCTGACAAACTACTGCCGTTTTGTGAATATCTGTTGATCACTGGCGGTCATGGTGATGAACAGCAAATCCATAACCG
CCTGTACCTGCGCGGCGGCCAGACCCACACCTTCGTCTGCGAGCGTCTGCCCGGTAGCTATCACGGTTCCGGCTGCACCC
TGGCCAGCGCACTGGCCGGGCGGATCGCCCAGGGGCAGGAGCTGGTCAGCGCGGTGAAGTCGGCACTCGACTACACCTGG
CGAACGCTGAGGGATGCCGAACAGTTGGGCCGGGGGCAATTCGTGCCACGTCGGCTGCCGCTGGATTTTTGCTCGTAA

Upstream 100 bases:

>100_bases
TTTTGTCGAGCCTGCCGTCGTCGCCGACTGACCTCGATCCGCAAGAAAAAACCGGCCCCCCGAGCGGCCCGCGAAAGGTT
TAGTGATAAGCTCGCGCACC

Downstream 100 bases:

>100_bases
CACATCGCCATGAGGGTCGATTCATGAAACTGCGTGGCCTGTATGCCATCACCGACAGCCAGTTGCTGTCCGGAAAATTT
CTGTCGTACGTCGAAGCGGC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MNIYSSRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPVITALTVQDTVNVSDFRVLDREWVMAQANAVLNDSSVAAV
KLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSTIATPNLPEARILAELPEGTADE
CADKLLPFCEYLLITGGHGDEQQIHNRLYLRGGQTHTFVCERLPGSYHGSGCTLASALAGRIAQGQELVSAVKSALDYTW
RTLRDAEQLGRGQFVPRRLPLDFCS

Sequences:

>Translated_265_residues
MNIYSSRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPVITALTVQDTVNVSDFRVLDREWVMAQANAVLNDSSVAAV
KLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSTIATPNLPEARILAELPEGTADE
CADKLLPFCEYLLITGGHGDEQQIHNRLYLRGGQTHTFVCERLPGSYHGSGCTLASALAGRIAQGQELVSAVKSALDYTW
RTLRDAEQLGRGQFVPRRLPLDFCS
>Mature_265_residues
MNIYSSRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPVITALTVQDTVNVSDFRVLDREWVMAQANAVLNDSSVAAV
KLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRLGKDEVGYAMRERLLPLSTIATPNLPEARILAELPEGTADE
CADKLLPFCEYLLITGGHGDEQQIHNRLYLRGGQTHTFVCERLPGSYHGSGCTLASALAGRIAQGQELVSAVKSALDYTW
RTLRDAEQLGRGQFVPRRLPLDFCS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=253, Percent_Identity=32.8063241106719, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325378, Length=250, Percent_Identity=32.8, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324997, Length=251, Percent_Identity=34.2629482071713, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324517, Length=249, Percent_Identity=32.9317269076305, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28414; Mature: 28414

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYSSRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPVITALTVQDTVNVSDFRVLD
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHEEEEEECCCCCCHHHHHHH
REWVMAQANAVLNDSSVAAVKLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
GKDEVGYAMRERLLPLSTIATPNLPEARILAELPEGTADECADKLLPFCEYLLITGGHGD
CHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCC
EQQIHNRLYLRGGQTHTFVCERLPGSYHGSGCTLASALAGRIAQGQELVSAVKSALDYTW
HHHHHHHHEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RTLRDAEQLGRGQFVPRRLPLDFCS
HHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIYSSRPVVLCLSGHDPSGGAGMQADIEALLAQGCHAAPVITALTVQDTVNVSDFRVLD
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCHHEEEEEECCCCCCHHHHHHH
REWVMAQANAVLNDSSVAAVKLGMLGSLEMVDTVVDLLLAHPHLPMVCDPVLRAGGGGRL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
GKDEVGYAMRERLLPLSTIATPNLPEARILAELPEGTADECADKLLPFCEYLLITGGHGD
CHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEECCCCC
EQQIHNRLYLRGGQTHTFVCERLPGSYHGSGCTLASALAGRIAQGQELVSAVKSALDYTW
HHHHHHHHEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RTLRDAEQLGRGQFVPRRLPLDFCS
HHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]