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The map label for this gene is glyA [H]

Identifier: 66047497

GI number: 66047497

Start: 5094122

End: 5095375

Strand: Direct

Name: glyA [H]

Synonym: Psyr_4270

Alternate gene names: 66047497

Gene position: 5094122-5095375 (Clockwise)

Preceding gene: 66047495

Following gene: 66047501

Centisome position: 83.6

GC content: 62.2

Gene sequence:

>1254_bases
ATGTTCAGCCGTGATTTGACTATCGCCAAGTACGACGCCGATCTGTTTGCCGCCATGGAGCAAGAAGCTCTGCGTCAGGA
AGAACACATCGAGCTGATTGCCTCGGAAAACTACACCAGTCCGGCCGTCATGGAAGCTCAGGGCTCGGCCCTGACCAACA
AGTACGCCGAAGGCTATCCAGGCAAGCGCTACTACGGTGGTTGCGAGTACGTCGACATTATCGAGCAACTGGCCATCGAC
CGCGCCAAGGAACTGTTCGGCGCTGATTACGCCAACGTCCAGCCACACGCCGGTTCGCAAGCCAACTCGGCGGTCTACCT
GGCCCTGCTGCAAGGCGGCGACACCATTCTGGGCATGAGCCTGGCTCACGGTGGTCACCTGACCCACGGCGCCAGCGTTT
CGTCCTCGGGCAAGCTGTACAACGCCGTTCAGTACGGCATCGATGCCAACGGCATGATCGACTACGACGAAGTCGAGCGC
CTGGCCGTCGAGCACAAGCCAAAAATGATCGTCGCCGGTTTCTCTGCCTACTCGCAGATCCTCGACTTCCCGCGCTTCCG
CGCCATCGCTGACAAGGTCGGTGCCTACCTGTTCGTCGACATGGCGCACGTCGCCGGTCTGGTCGCCGCAGGCGTCTACC
CGAACCCGGTGCCATTCGCCGACGTCGTGACCACCACCACGCACAAGACCCTGCGCGGTCCGCGTGGCGGCCTGATCCTG
GCGCGCGCCAACGCCGAGATCGAGAAGAAGCTGAACTCGGCGGTGTTCCCTGGCTCCCAGGGCGGCCCGCTGGAGCACGT
CATCGCGGCCAAGGCCGTGTGCTTCAAGGAAGCGCTGCAGCCTGAGTTCAAGACCTACCAGCAGCAAGTGGTGAAGAACG
CCAAGGCCATGGCCGGCGTGTTCATCGAGCGTGGCTTCGACGTCGTTTCCGGCGGTACCGAGAACCACCTGTTCCTGCTG
TCGCTGATCAAACAGGACATCTCCGGTAAAGACGCTGACGCCGCTCTGGGTCGCGCCTTCATCACCGTCAACAAGAACTC
CGTACCGAACGACCCACGCTCCCCGTTCGTCACCTCCGGCCTGCGCTTCGGCACCCCGGCAGTGACCACTCGCGGCTTCA
AGGAAGCTGAGTGCAAGGAACTGGCCGGCTGGATCTGCGACATCCTGGCTGACCTGAACAACGAAGCCGTGATCGACGCG
GTTCGTGAGAAGGTCAAGGCCATCTGCGCCAAGCTGCCGGTTTACGGCGCTTGA

Upstream 100 bases:

>100_bases
GAACGCGGTCACTGGTCAAGATGACTGCCTTTCATATGCCAGATAAAACCCGATGGGGTAGAATAGTCGCCTTTTCCGCC
ATGCCCCCTTGAGGACTGCC

Downstream 100 bases:

>100_bases
TGAGTTTGGTTTAAACGCAGTACCAAAAGCCCCGACTTGTGAGAGCCGGGGCTTTTTGTTGGACGCTCACCGTATGGACA
GAAGCTCAGCCGCTGCCCGA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYPGKRYYGGCEYVDIIEQLAID
RAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
ARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGVFIERGFDVVSGGTENHLFLL
SLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICAKLPVYGA

Sequences:

>Translated_417_residues
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYPGKRYYGGCEYVDIIEQLAID
RAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
ARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGVFIERGFDVVSGGTENHLFLL
SLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICAKLPVYGA
>Mature_417_residues
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYPGKRYYGGCEYVDIIEQLAID
RAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVER
LAVEHKPKMIVAGFSAYSQILDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
ARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGVFIERGFDVVSGGTENHLFLL
SLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDA
VREKVKAICAKLPVYGA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=402, Percent_Identity=46.2686567164179, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=46.2686567164179, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=46.2686567164179, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=46.2686567164179, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862346, Length=401, Percent_Identity=45.3865336658354, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI22547186, Length=451, Percent_Identity=42.1286031042129, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=39.9543378995434, Blast_Score=283, Evalue=2e-76,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=75.2403846153846, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=47.75, Blast_Score=358, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=47.75, Blast_Score=358, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=46.3840399002494, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=43.8287153652393, Blast_Score=333, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=48, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=48, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44858; Mature: 44858

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYP
CCCCCCEEEEECHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYVDIIEQLAIDRAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEE
LAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVERLAVEHKPKMIVAGFSAYSQI
ECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
LDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
ARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGV
EECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FIERGFDVVSGGTENHLFLLSLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSG
HHHCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHCEEEEEEECCCCCCCCCCCHHHCC
LRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICAKLPVYGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSRDLTIAKYDADLFAAMEQEALRQEEHIELIASENYTSPAVMEAQGSALTNKYAEGYP
CCCCCCEEEEECHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEYVDIIEQLAIDRAKELFGADYANVQPHAGSQANSAVYLALLQGGDTILGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEE
LAHGGHLTHGASVSSSGKLYNAVQYGIDANGMIDYDEVERLAVEHKPKMIVAGFSAYSQI
ECCCCCCCCCCCCCCCCCEEHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
LDFPRFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLIL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
ARANAEIEKKLNSAVFPGSQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVVKNAKAMAGV
EECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
FIERGFDVVSGGTENHLFLLSLIKQDISGKDADAALGRAFITVNKNSVPNDPRSPFVTSG
HHHCCCCEECCCCCCHHHHHHHHHHHCCCCCCHHHHCEEEEEEECCCCCCCCCCCHHHCC
LRFGTPAVTTRGFKEAECKELAGWICDILADLNNEAVIDAVREKVKAICAKLPVYGA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA